Expressão gênica de fatores de virulência de Corynebacterium pseudotuberculosis e o seu papel na patogênese da Linfadenite caseosa
DOI:
https://doi.org/10.33448/rsd-v11i14.36061Palavras-chave:
Corynebacterium pseudotuberculosis; Fatores de virulência; Imunidade.Resumo
Corynebacterium pseudotuberculosis é o agente causador da linfadenite caseosa (LC), uma doença infecciosa, granulomatosa, crônica e debilitante que acomete diversos animais, entre eles, caprinos, ovinos, bovinos, equinos, camelídeos e, mais raramente, seres humanos. O grupo denominado CMNR, composto por bactérias dos gêneros Corynebacterium, Mycobacterium, Nocardia e Rhodococcus, está envolvido em diversas patologias importantes, tanto na medicina humana quanto na veterinária. O foco dos estudos com o agente etiológico da LC tem sido em relação ao diagnóstico, epidemiologia, profilaxia, terapêutica e genômica. Embora a doença seja estudada desde o início do século XX, de forma similar àquelas causadas por outras entidades bacterianas, o levantamento acerca dos mecanismos patofisiológicos e de evasão deste agente são praticamente desconhecidos. Os fatores de virulência do agente etiológico da linfadenite caseosa são pouco numerosos, mas o sequenciamento pioneiro do genoma de uma cepa isolada de um paciente humano, C. pseudotuberculosis FRC41, permitiu a identificação e anotação de diversos genes codificadores de proteínas cujas características fisiológicas se ajustam à definição de fator de virulência. Em Mycobacterium tuberculosis, a cinase PknG controla o metabolismo da glutamina, mas pode ser secretada dentro de fagossomos de macrófagos, interferindo na maturação destas organelas. A mesma enzima existe em outros representantes da subordem Corynebacterineae, incluindo Corynebacterium pseudotuberculosis outros antígenos já foram descritos e suas estão aser elucidadas. Neste contexto, o objetivo desse trabalho foi realizar uma revisão a cerca dos fatores de virulência do C. pseudotuberculosis.
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Copyright (c) 2022 Jefferson Ivan Corrêa; José Tadeu Raynal Rocha Filho; Bruno Lopes Bastos; Daniel Menezes Bonaspetti; Júlia Maria Guimarães Matos; Ezequiel Fabiane Spanholi; Antonio Pedro Fróes de Farias; Lília Ferreira de Moura-Costa; Soraya Castro Trindade; Roberto José Meyer Nascimento
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