Exposición a plaguicidas y sobrepeso - Una revisión sistemática

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i14.36493

Palabras clave:

Agroquímicos; Disruptores endocrinos; Sobrepeso; Comorbilidades associadas.

Resumen

Este estudio es el resultado de una revisión sistemática para investigar la posible relación entre la exposición a plaguicidas y la inducción del sobrepeso corporal en individuos adultos. Se utilizó la estrategia PICO (Population, Interventions/exposure, Comparisons, Outcomes) y las bases de datos PUBMED, SCIENCE DIRECT y SCOPUS para realizar la búsqueda. En esta revisión, se incluyeron 15 estudios. Los datos presentados demostraron que el 86,66% (13/15) de los estudios correlacionaron positivamente el sobrepeso y la exposición a plaguicidas. Además, se observó que la exposición a plaguicidas afectaba al mecanismo de desregulación de la glucosa (aumento de los niveles de glucosa, insulina e índice de resistencia a la insulina del modelo de homeostasis (HOMA-IR)) y a la desregulación de la homeostasis de los lípidos (aumento de los niveles de triglicéridos y disminución de los niveles de lipoproteínas de alta densidad (HDL)). Estos resultados proponen un aumento del riesgo de enfermedades cardíacas y de diabetes. Además, estos resultados muestran que la exposición a los pesticidas también puede aumentar el riesgo de desarrollar sobrepeso. Sin embargo, se necesitan más estudios para determinar el posible mecanismo.

Citas

Abubakar, Y., Tijjani, H., Egbuna, C., Adetunji, C. O., Kala, S., Kryeziu, T. L., Ifemeje, J. C., & Patrick-Iwuanyanwu, K. C. (2020). Pesticides, History, and Classification. In Natural Remedies for Pest, Disease and Weed Control (pp. 29–42). https://doi.org/10.1016/B978-0-12-819304-4.00003-8

Aminov, Z., & Carpenter, D. O. (2020). Serum concentrations of persistent organic pollutants and the metabolic syndrome in Akwesasne Mohawks, a Native American community. Environmental Pollution, 260. https://doi.org/10.1016/j.envpol.2020.114004

Archibeque-Engle, S. L., Tessari, J. D., Winn, D. T., Keefe, T. J., Nett, T. M., & Zheng, T. (1997). Comparison of organochlorine pesticide and polychlorinated biphenyl residues in human breast adipose tissue and serum. Journal of Toxicology and Environmental Health, 52(4), 285–293. https://doi.org/10.1080/00984109708984065

Aronson, K. J., Miller, A. B., Wooleott, C. G., Sterns, E. E., McCready, D. R., Lickley, L. A., Fish, E. B., Hiraki, G. Y., Holloway, C., Ross, T., Hanna, W. M., SenGupta, S. K., & Weber, J. P. (2000). Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk. Cancer Epidemiology Biomarkers and Prevention, 9(1), 55–63.

Arrebola, J. P., Cuellar, M., Claure, E., Quevedo, M., Antelo, S. R., Mutch, E., Ramirez, E., Fernandez, M. F., Olea, N., & Mercado, L. A. (2012). Concentrations of organochlorine pesticides and polychlorinated biphenyls in human serum and adipose tissue from Bolivia. Environmental Research, 112, 40–47. https://doi.org/10.1016/j.envres.2011.10.006

Azandjeme, C. S., Delisle, H., Fayomi, B., Ayotte, P., Djrolo, F., Houinato, D., & Bouchard, M. (2014). High serum organochlorine pesticide concentrations in diabetics of a cotton producing area of the Benin Republic (West Africa). Environment International, 69, 1–8. https://doi.org/10.1016/j.envint.2014.04.002

Botella, B., Crespo, J., Rivas, A., Cerrillo, I., Olea-Serrano, M. F., & Olea, N. (2004). Exposure of women to organochlorine pesticides in Southern Spain. Environmental Research, 96(1), 34–40. https://doi.org/10.1016/j.envres.2003.10.001

CAMEO Chemicals. (n.d.-a). DDT AND METABOLITES. https://cameochemicals.noaa.gov/chemical/17865

CAMEO Chemicals. (n.d.-b). DIELDRIN. https://cameochemicals.noaa.gov/chemical/3187

CAMEO Chemicals. (n.d.-c). OCTACHLORODIBENZO-P-DIOXIN. https://cameochemicals.noaa.gov/chemical/20807

CAMEO Chemicals. (n.d.-d). HEXACHLOROBENZENE. https://cameochemicals.noaa.gov/chemical/3556

CAMEO Chemicals. (n.d.-e). HEXACHLOROCYCLOHEXANE (ALL ISOMERS). https://cameochemicals.noaa.gov/chemical/18038

CAMEO Chemicals. (n.d.-f). 2,5-DICHLOROPHENOL. https://cameochemicals.noaa.gov/chemical/20162

CAMEO Chemicals. (n.d.-g). CHLORDANE (TECHNICAL MIXTURE AND METABOLITES). https://cameochemicals.noaa.gov/chemical/16288

Cappuccio, F. P., Taggart, F. M., Kandala, N.-B., Currie, A., Peile, E., Stranges, S., & Miller, M. A. (2008). Meta-Analysis of Short Sleep Duration and Obesity in Children and Adults. Sleep, 31(5), 619–626. https://doi.org/10.1093/sleep/31.5.619

Chevrier, J., Dewailly, É., Ayotte, P., Mauriège, P., Després, J. P., & Tremblay, A. (2000). Body weight loss increases plasma and adipose tissue concentrations of potentially toxic pollutants in obese individuals. International Journal of Obesity, 24(10), 1272–1278. https://doi.org/10.1038/sj.ijo.0801380

Combarnous, Y. (2017). Endocrine Disruptor Compounds (EDCs) and agriculture: The case of pesticides. Comptes Rendus Biologies, 340(9–10), 406–409. https://doi.org/10.1016/j.crvi.2017.07.009

Curtis D. Klaassen. (1986). Casarett and Doull’s Toxicology: The Basic Science of Poisons (Macmillan (Ed.); 3rd ed.). https://doi.org/10.1036/0071470514

Dhaliwal, S. S., & Welborn, T. A. (2009). Central Obesity and Multivariable Cardiovascular Risk as Assessed by the Framingham Prediction Scores. American Journal of Cardiology, 103(10), 1403–1407. https://doi.org/10.1016/j.amjcard.2008.12.048

Dirinck, E., Jorens, P. G., Covaci, A., Geens, T., Roosens, L., Neels, H., Mertens, I., & Van Gaal, L. (2011). Obesity and persistent organic pollutants: Possible obesogenic effect of organochlorine pesticides and polychlorinated biphenyls. Obesity, 19(4), 709–714. https://doi.org/10.1038/oby.2010.133

Dirinck, E. L., Dirtu, A. C., Govindan, M., Covaci, A., Van Gaal, L. F., & Jorens, P. G. (2014). Exposure to persistent organic pollutants: Relationship with abnormal glucose metabolism and visceral adiposity. Diabetes Care, 37(7), 1951–1958. https://doi.org/10.2337/dc13-2329

Dusanov, S., Ruzzin, J., Kiviranta, H., Klemsdal, T. O., Retterstøl, L., Rantakokko, P., Airaksinen, R., Djurovic, S., & Tonstad, S. (2018). Associations between persistent organic pollutants and metabolic syndrome in morbidly obese individuals. Nutrition, Metabolism and Cardiovascular Diseases, 28(7), 735–742. https://doi.org/10.1016/j.numecd.2018.03.004

Elagizi, A., Kachur, S., Lavie, C. J., Carbone, S., Pandey, A., Ortega, F. B., & Milani, R. V. (2018). An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases. Progress in Cardiovascular Diseases, 61(2), 142–150. https://doi.org/10.1016/j.pcad.2018.07.003

Grundy, S. M. (1998). Hypertriglyceridemia, Atherogenic Dyslipidemia, and the Metabolic Syndrome. The American Journal of Cardiology, 81(4), 18B-25B. https://doi.org/10.1016/S0002-9149(98)00033-2

He, B., Ni, Y., Jin, Y., & Fu, Z. (2020). Pesticides-induced energy metabolic disorders. Science of the Total Environment, 729, 1–9. https://doi.org/10.1016/j.scitotenv.2020.139033

Henríquez-Hernández, L. A., Luzardo, O. P., Valerón, P. F., Zumbado, M., Serra-Majem, L., Camacho, M., González-Antuña, A., & Boada, L. D. (2017). Persistent organic pollutants and risk of diabetes and obesity on healthy adults: Results from a cross-sectional study in Spain. Science of the Total Environment, 607–608, 1096–1102. https://doi.org/10.1016/j.scitotenv.2017.07.075

Hue, O., Marcotte, J., Berrigan, F., Simoneau, M., Doré, J., Marceau, P., Marceau, S., Tremblay, A., & Teasdale, N. (2007). Plasma concentration of organochlorine compounds is associated with age and not obesity. Chemosphere, 67(7), 1463–1467. https://doi.org/10.1016/j.chemosphere.2006.10.033

Jansen, A., Polder, A., Müller, M. H. B., Skjerve, E., Aaseth, J., & Lyche, J. L. (2018). Increased levels of persistent organic pollutants in serum one year after a great weight loss in humans: Are the levels exceeding health based guideline values? Science of the Total Environment, 622–623, 1317–1326. https://doi.org/10.1016/j.scitotenv.2017.11.241

Janssen, I., Katzmarzyk, P. T., & Ross, R. (2004). Waist circumference and not body mass index explains obesity-related health risk. American Journal of Clinical Nutrition, 79(3), 379–384. https://doi.org/10.1093/ajcn/79.3.379

Katsuki, A., Sumida, Y., Gabazza, E. C., Murashima, S., Furuta, M., Araki-Sasaki, R., Hori, Y., Yano, Y., & Adachi, Y. (2001). Homeostasis model assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes. Diabetes Care, 24(2), 362–365. https://doi.org/10.2337/diacare.24.2.362

Kim, K. S., Lee, Y. M., Kim, S. G., Lee, I. K., Lee, H. J., Kim, J. H., Kim, J., Moon, H. B., Jacobs, D. R., & Lee, D. H. (2014). Associations of organochlorine pesticides and polychlorinated biphenyls in visceral vs. subcutaneous adipose tissue with type 2 diabetes and insulin resistance. Chemosphere, 94, 151–157. https://doi.org/10.1016/j.chemosphere.2013.09.066

Kohlmeier, L., & Kohlmeier, M. (1995). Adipose tissue as a medium for epidemiologic exposure assessment. Environmental Health Perspectives, 103(suppl 3), 99–106. https://doi.org/10.1289/ehp.95103s399

Lee, D. H., Lee, I. N. K., Jin, S. H., Steffes, M., & Jacobs, D. R. (2007). Association between serum concentrations of persistent organic pollutants and insulin resistance among nondiabetic adults: Results from the National Health and Nutrition Examination Survey 1999-2002. Diabetes Care, 30(3), 622–628. https://doi.org/10.2337/dc06-2190

Lee, D. H., Lind, L., Jacobs, D. R., Salihovic, S., van Bavel, B., & Lind, P. M. (2012). Associations of persistent organic pollutants with abdominal obesity in the elderly: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Environment International, 40(1), 170–178. https://doi.org/10.1016/j.envint.2011.07.010

Lee, D. H., Steffes, M. W., Sjödin, A., Jones, R. S., Needham, L. L., & Jacobs, D. R. (2011). Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes. PLoS ONE, 6(1). https://doi.org/10.1371/journal.pone.0015977

Liang, Y., Liu, D., Zhan, J., Luo, M., Han, J., Wang, P., & Zhou, Z. (2020). New insight into the mechanism of POP-induced obesity: Evidence from DDE-altered microbiota. Chemosphere, 244, 125123. https://doi.org/10.1016/j.chemosphere.2019.125123

Lind, P. M., Lee, D. H., Jacobs, D. R., Salihovic, S., Bavel, B. van, Wolff, M. S., & Lind, L. (2013). Circulating levels of persistent organic pollutants are related to retrospective assessment of life-time weight change. Chemosphere, 90(3), 998–1004. https://doi.org/10.1016/j.chemosphere.2012.07.051

Liu, Q., Wang, Q., Xu, C., Shao, W., Zhang, C., Liu, H., Jiang, Z., & Gu, A. (2017). Organochloride pesticides impaired mitochondrial function in hepatocytes and aggravated disorders of fatty acid metabolism. Scientific Reports, 7(1), 46339. https://doi.org/10.1038/srep46339

Mangum, L. H., Crow, J. A., Stokes, J. V., Howell, G. E., Ross, M. K., Pruett, S. B., & Chambers, J. E. (2016). Exposure to p,p’-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular Fraction. Toxicological Sciences, 150(1), 169–177. https://doi.org/10.1093/toxsci/kfv315

Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985). Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7), 412–419. https://doi.org/10.1007/BF00280883

Methley, A. M., Campbell, S., Chew-Graham, C., McNally, R., & Cheraghi-Sohi, S. (2014). PICO, PICOS and SPIDER: A comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews. BMC Health Services Research, 14(1). https://doi.org/10.1186/s12913-014-0579-0

Min, J. Y., Cho, J. S., Lee, K. J., Park, J. B., Park, S. G., Kim, J. Y., & Min, K. B. (2011). Potential role for organochlorine pesticides in the prevalence of peripheral arterial diseases in obese persons: Results from the National Health and Nutrition Examination Survey 1999-2004. Atherosclerosis, 218(1), 200–206. https://doi.org/10.1016/j.atherosclerosis.2011.04.044

Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., Estarli, M., Barrera, E. S. A., Martínez-Rodríguez, R., Baladia, E., Agüero, S. D., Camacho, S., Buhring, K., Herrero-López, A., Gil-González, D. M., Altman, D. G., Booth, A., & Whitlock, E. (2016). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Revista Espanola de Nutricion Humana y Dietetica, 20(2), 148–160. https://doi.org/10.1186/2046-4053-4-1

Monneret, C. (2017). What is an endocrine disruptor? Comptes Rendus - Biologies, 340(9–10), 403–405. https://doi.org/10.1016/j.crvi.2017.07.004

Nonterah, E. A., Debpuur, C., Agongo, G., Amenga-Etego, L., Crowther, N. J., Ramsay, M., & Rexford Oduro, A. (2018). Socio-demographic and behavioural determinants of body mass index among an adult population in rural Northern Ghana: the AWI-Gen study. Global Health Action, 11. https://doi.org/10.1080/16549716.2018.1467588

Nuttall, F. Q. (2015). Body mass index: Obesity, BMI, and health: A critical review. Nutrition Today, 50(3), 117–128. https://doi.org/10.1097/NT.0000000000000092

Pakzad, M., Fouladdel, S., Nili-Ahmadabadi, A., Pourkhalili, N., Baeeri, M., Azizi, E., Sabzevari, O., Ostad, S. N., & Abdollahi, M. (2013). Sublethal exposures of diazinon alters glucose homostasis in Wistar rats: Biochemical and molecular evidences of oxidative stress in adipose tissues. Pesticide Biochemistry and Physiology, 105(1), 57–61. https://doi.org/10.1016/j.pestbp.2012.11.008

Peppa, M., Uribarri, J., & Vlassara, H. (2003). Glucose, Advanced Glycation End Products, and Diabetes Complications: What Is New and What Works. Clinical Diabetes, 21(4), 186–187. https://doi.org/10.2337/diaclin.21.4.186

Raafat, N., Abass, M. A., & Salem, H. M. (2012). Malathion exposure and insulin resistance among a group of farmers in Al-Sharkia governorate. Clinical Biochemistry, 45(18), 1591–1595. https://doi.org/10.1016/j.clinbiochem.2012.07.108

Rönn, M., Lind, L., Bavel, B. van, Salihovic, S., Michaëlsson, K., & Lind, P. M. (2011). Circulating levels of persistent organic pollutants associate in divergent ways to fat mass measured by DXA in humans. Chemosphere, 85(3), 335–343. https://doi.org/10.1016/j.chemosphere.2011.06.095

Singh, V. K., Sarkar, S. K., Saxena, A., & Koner, B. C. (2019). Effect of Subtoxic DDT Exposure on Glucose Uptake and Insulin Signaling in Rat L6 Myoblast-Derived Myotubes. International Journal of Toxicology, 38(4), 303–311. https://doi.org/10.1177/1091581819850577

Smith, A., Yu, X., & Yin, L. (2018). Diazinon exposure activated transcriptional factors CCAAT-enhancer-binding proteins α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ) and induced adipogenesis in 3T3-L1 preadipocytes. Pesticide Biochemistry and Physiology, 150(November 2017), 48–58. https://doi.org/10.1016/j.pestbp.2018.07.003

Trasande, L., & Blumberg, B. (2018). Endocrine Disruptors as Obesogens. In Pediatric Obesity (Vol. 304, pp. 243–253). https://doi.org/10.1007/978-3-319-68192-4_14

Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. a, Jason, P., Egholm, M., Henrissat, B., Heath, A. C., Knight, R., Gordon, J. I., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., & Gordon, J. I. (2009). A core gut microbiome between lean and obesity twins. Nature, 457(7228), 480–484. https://doi.org/10.1038/nature07540.A

Wei, Y., Zhu, J., & Nguyen, A. (2014). Urinary concentrations of dichlorophenol pesticides and obesity among adult participants in the U.S. National Health and Nutrition Examination Survey (NHANES) 2005-2008. International Journal of Hygiene and Environmental Health, 217(2–3), 294–299. https://doi.org/10.1016/j.ijheh.2013.07.003

World Health Organization. (2020). Obesity and overweight. 2020. https://doi.org/https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight

Descargas

Publicado

07/11/2022

Cómo citar

SKONIESKI, C. .; SILVA, L.; FAGUNDES, K. R.; NUNES, A. T. .; FINHLER, S. .; ROVERSI , . K. .; GALLINA, A. L. .; HIRATA, M. H. .; FERREIRA, G. M.; BENVEGNÚ, D. M. . Exposición a plaguicidas y sobrepeso - Una revisión sistemática. Research, Society and Development, [S. l.], v. 11, n. 14, p. e596111436493, 2022. DOI: 10.33448/rsd-v11i14.36493. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36493. Acesso em: 25 nov. 2024.

Número

Vol. 11 Núm. 14

Sección

Ciencias de la salud

Licencia

Derechos de autor 2022 Calinca Skonieski; Larissa Silva; Karina Raquel Fagundes; Andressa Talita Nunes; Suelen Finhler; Karine Roversi ; André Lazarin Gallina; Mario Hiroyuki Hirata; Glaucio Monteiro Ferreira; Dalila Moter Benvegnú

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

Los autores que publican en esta revista concuerdan con los siguientes términos:

1) Los autores mantienen los derechos de autor y conceden a la revista el derecho de primera publicación, con el trabajo simultáneamente licenciado bajo la Licencia Creative Commons Attribution que permite el compartir el trabajo con reconocimiento de la autoría y publicación inicial en esta revista.

2) Los autores tienen autorización para asumir contratos adicionales por separado, para distribución no exclusiva de la versión del trabajo publicada en esta revista (por ejemplo, publicar en repositorio institucional o como capítulo de libro), con reconocimiento de autoría y publicación inicial en esta revista.

3) Los autores tienen permiso y son estimulados a publicar y distribuir su trabajo en línea (por ejemplo, en repositorios institucionales o en su página personal) a cualquier punto antes o durante el proceso editorial, ya que esto puede generar cambios productivos, así como aumentar el impacto y la cita del trabajo publicado.