Factores de riesgo gestacional en madres de niños diagnosticados con autismo

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i15.37837

Palabras clave:

Obstetricia; Trastorno del neurodesarrollo; Desorden del espectro autista.

Resumen

Este estudio tiene como objetivo identificar posibles factores de riesgo gestacionales para el desarrollo del Trastorno del Espectro Autista (TEA). El estudio es cuantitativo, descriptivo, documental, con análisis exploratorio de datos. Para su realización se utilizaron datos secundarios de 32 historias clínicas de niños diagnosticados con Autismo clásico. En cuanto a la edad de los padres al momento de la concepción, el mayor porcentaje de madres estuvo entre 20 y 30 años (56,25%) y de padres entre 32 y 45 años (59,38%). Las Infecciones del Tracto Urinario (ITU) fueron las infecciones más frecuentes durante el embarazo (43,80%). En cuanto a las demás complicaciones clínicas prenatales, prevalecieron los diferentes tipos (40,63%), seguido de los trastornos metabólicos (25,00%). Para las complicaciones peri y posnatales, la mayoría se definió como de diferente tipo (43,75%), seguido de la prematuridad (28,13%). Con respecto a los medicamentos utilizados durante el embarazo, la mayoría de las madres utilizaron diferentes tipos de medicamentos (56,25 %), seguidos de antibióticos (50,00 %). De esa forma, buscar conocer los probables factores ambientales involucrados en la etiología del TEA, permite al profissional identificar las gestantes más susceptibles y buscar estrategias de intervención oportunas en el prenatal.

Citas

Abdallah, M. W., Larsen, N., Grove, J., Nørgaard-pedersen, B., Thorsen, P., Mortensen, E. L., & Hougaard, D. M. (2011). Amniotic fluid inflammatory cytokines: potential markers of immunologic dysfunction in autism spectrum disorders. World J Biol. Psychiatry. 14(7), 528-538.

Apa. American psychiatric association. (2013). Manual Diagnóstico e Estatístico dos Transtornos Mentais (DSM V). (4a. ed.) rev. Porto Alegre: Artmed.

Atladóttir, H. O., Henriksen, T. B., Schendel, D. E., & Parner, E.T. (2012). Autism After Infection, Febrile Episodes, and Antibiotic Use During Pregnancy: An Exploratory Study. Pediatrics. 130 (6): 1447-1454.

Atladottir, H. O., Thorsen, P., Ostergaard, L., Schendel, D. E., Lemcke, S., Abdallah, M., & Parner, E. T. (2010). Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. Journal of Autism and Developmental Disorders. 40 (12): 1423-1430.

Bambini-junior, V., Rodrigues, L., Behr, G. A., Moreira, J. C. F., Riesgo, R., & Gottfried, C. (2011). Animal modelo autismo induced by prenatal exposure to valproate. Behavioral changes and liver parameters. Brain Research. 1408: 8-16.

Bauer, A. Z., & Kriebel, D. (2013). Prenatal and perinatal analgesic exposure and autism: an ecological link. Environmental Health. 12 (41): 1-13.

Bello, B., Heederik, D., Kielkowsk, D., & Wilson, K. (2016). Increased time-to-pregnancy is associated with domestic work in South Africa. Reproductive Health. 13: 1-9.

Biri, A., Onan, A., Devrim, E., Babacan, F., Kavutcu, M., & Durak, I. (2006). Oxidant status in maternal and cord plasma and placental tissue in gestational diabetes. Placenta. 27: 327-332.

Brasil. (2012a.) Ministério da Saúde. Atenção ao pré-natal de baixo risco. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Cadernos de Atenção Básica, n° 32, 318 p. Brasília: Editora do Ministério da Saúde.

Brasil. (2012b). Ministério da Saúde. Gestação de alto risco: manual técnico. Secretaria de Atenção à Saúde/Departamento de Ações Programáticas Estratégicas. (5a ed.): Editora do Ministério da Saúde.

Brimacombe, M., Ming, X., & Lamendola, M. (2007). Prenatal complications in autism. Modern child health jornal. 11: 73-79.

Boksa, P. (2010). Effects of prenatal infection on brain development and behavior: a review of findings from animal models, USA. Brain, Behavior and Immunity. 24: 881-897.

Bolivar, V. J., Walters, S. R., & Phoenix, J. L. (2007). Assessing autism-like behavior in mice: Variations in social interactions among inbred strains, USA. Behavioural Brain Research. 176: 21-26.

Buemo, B., Alli, F., Iracet, J. V., Ribas, L., Pereira, R., Kruel, C. S., & Carlesso, J. P. P. (2019). Autismo no Contexto Escolar: A Importância da Inserção Social. Research, Society and Development, 8(3), 01-13.

Burstyn, I., Wang, X., Yasui, Y., Sithole, F., & Zwaigenbaum, L. (2011). Autism spectrum disorders and fetal hypoxia in a population-based cohort: accounting for missing exposures via Estimation-Maximization algorithm. BMC medical research methodology. 11 (1): 1-9.

Bussab, O.W., & Morettin, A. P. (2005). Estatística Básica, (5ª edição), Ed. Saraiva, São Paulo.

Cavalcante, A. O., Dotto, L. M. G., Koifman, S., Cunha, M. A., Oliveira, M. F. S., & Mamede, M. V. (2011). Atenção pré-natal no município de Rio Branco, Acre: Inquérito de base populacional, 2007-2008, BRASIL. Revista Baiana de Saúde Pública. 35 (3): 661-675.

Cha, J., Sun, X., & Dey, S. K. (2012). Mechanisms of implantation: strategies for successful pregnancy. Nature Medicine. 18: 1754-1767.

Chauhan, A., Chauhan, V., Brown, W. T., & Cohen, I. (2004). Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin–the antioxidant proteins. Life Sciences. 75 (21): 2539-2549.

Chen, X., & Scholl, T. O. (2005). Oxidative stress: Changes in pregnancy and with gestational diabetes mellitus. Current Diabetes Reports. 5 (4): 282-288.

Currenti, S. A. (2010). Understanding and determining the etiology of autism, USA. Cellular and Molecular Neurobiology. 30: 161-171.

Deverman, B. E., & Patterson, P. H. (2009). Cytokines and CNS Development. Neuron – Cell Press. 64 (1): 61-78.

Dimova, S., Hoet, P. H. M., Dinsdale, D., & Newery, B. (2004). Acetaminophen decreases intercellular glutathione levels and modulate cytokine production in human alveolar macrophages and type II pneumocytes in vitro. Int. J. Bio. Chem. Cell Biol. 37: 1727-1737.

Eidelman, A. I., & Samueloff, A. (2002). The pathophysiology of the fetus of the diabetic mother. Seminars in Perinatology. 26 (3): 232-236.

Farquhar, H., Stewart, A., & Mitchell, E. (2010). The role of paracetamol in the pathogenesis of asthma. Clin. Exp. Allergy. 40 (1): 32-41.

Gadia, C. A., Tuchman, R., & Rotta, N. T. (2004). Autismo e doenças invasivas de desenvolvimento, Brasil. Jornal de Pediatria. 80 (2): 83-94.

Gardener, H., Spiegelman, D., & Buka, S. L. (2009). Prenatal Risk Factors for Autism: A Comprehensive Meta-analysis. Pediatrics. Jul; 195 (1): 7-14.

Guinchat, V., Thorsen, P., Laurent, C., Cans, C., Bodeau, N., & Cohen, D. (2012). Pre, peri and neonatal risk factors for autism. Acta Obstetric et Gynecologica. 91(3): 287-300.

Gumusoglu, S. B., Fine, R. S., Murray, S. J., Bittle, J. L., & Stevens, H. E. (2017). The role of IL-6 in neurodevelopment after prenatal stress. Brain. Behav. Immun. 65:274-283.

Hadjkacema, I., Ayadia, H., Turkia, M., Yaichb, S., Khemekhema, K., Walhaa, A., Cherifa, L., Moallaa, Y., & Ghribia, F. (2016). Prenatal, perinatal and postnatal factors associated with autism spectrum disorder. J. Pediatr. 92: 595-601.

Herbert, M. R. (2010). Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders, USA. Curr. Opin. Neurol. 23(2): 103-110.

James, S. J., Melnyk, S., Jernigan, S., Hubanks, A., Rose, S., & Gaylor, D. W. (2008). Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism. J Autism Dev. Disord. 38 (10): 1966-1975.

Jetten, M. J., Gaj, S., Ruiz-aracama, A., Kok, de T. M., Van, D. J. H., Lommen, A., Van, S. E. P., Jennen, D. G., Claessen, S. M., Peijnenburg, A. A., Stierum, R. H., & Kleinjans, J. C. (2012). Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans. Toxicol. Appl. Pharmacol. 259 (3): 320-328.

Kirsten, T. B. (2012). Lipopolissacarídeo no início do período pré-natal como modelo experimental de autismo e prejuízos dopaminérgicos estriatais. 195f. Tese (Doutorado), Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia, São Paulo.

Kern, J. K., Ramsden, D. B., Grannemann, B. D., & Garver, C. R. (2004). Abnormal Sulfation Chemistry in Autism. In Trends in Autism, Research. Nova Biomedical Books. 211.

Kolevzon, A., Gross, R., & Reichenberg, A. (2007). Prenatal and Perinatal Risk Factors for Autism. Arch. Pediatr. Adolesc. Med. 161 (4): 326-333.

Kong, A., et al. (2012). Rate of de novo mutations, father’s age, and disease risk. HHS Public. Access. 488 (7412): 471–475.

Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., Schendel, D., Thorsen, P., & Mortensen, P. B. (2005). Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. American Journal of Epidemiology. 161 (10): 916-925.

Libbey, J. E., Sweeten, T. L., Mcmahon, W. M., & Fujinami, R. S. (2005). Autistic disorder and viral infections. Journal of Neuro. Virology. 11 (1): 1–10.

Loughran, A. J., & Tuomanen, E. I. (2016). Blood borne: bacterial components in mother’s blood influence fetal development. Inflamm. Cell Signal. 3 (4): 1-6.

Martini, J., Knappe, S., Beesdom–baum, K., Lieb, R., & Wittchen, H. U. (2010). Anxiety disorder before birth and self perceived distress during pregnancy: Associations with maternal depression and obstetric, neonatal and early childhood outcomes. Early Human development. 86: 305 – 310.

Martins, R. X. (2013). Metodologia de pesquisa: guia de estudos, Lavras-MG. Universidade Federal de Lavras, UFLA. 1-84.

Ming, X., Stein, T. P., Brimacombe, M., Johnson, W. G., Lambert, G. H., & Wagner, G. C. (2005). Increased excretion of a lipid peroxidation biomarker in autism. Prostaglandins Leukotrienes and Essential Fatty Acids. 73 (5): 379-384.

Muhle, R., Trentacoste, S. V., & Rapin, I. (2004). The genetics of autism, USA. Pediatrics. 113 (5): 472–486.

Neves, K. C., Felix, D. P. S., Ribeiro, W. A., Fassarella, B. P. A., & Da Silva, A. A. (2020). Acolhimento à pessoa com transtorno do espectro autista: um desafio para assistência de Enfermagem. Research, Society and Development, 9(8), e941986742.

Neerhof, M. G., Thaete, L. G. (2008). The fetal response to chronic placental insufficiency. Seminars in perinatology. 32 (3): 201-205.

Nunes, A. K. A., Sousa, F. D. C. A., da Silva, F. L., da Silva, W. C., Hernandes, L. F., da Silva, M. G. S., & da Silva, E. B. (2020). Assistência de enfermagem à criança com autismo. Research, Society and Development, 9(11), e86991110114-e86991110114.

Oliveira, M. M. (2007). Como fazer pesquisa qualitativa. Petrópolis, Vozes.

Onore, C., Careaga, M., & Ashwood, P. (2012). The role of immune dysfunction in the pathophysiology of autism. Brain, Behavior, and Immunity. 26 (3): 383-392.

Organização Mundial da Saúde. Constituição da Organização Mundial da Saúde (OMS). 2017. https://www.paho.org/bra/index.php?option=com_content&view=article&id=5651:folha-informativa-transtornos-do-espectro-autista&Itemid=839

Ornoy, A. L., Weinstein-fudim, L., & Ergaz, Z. (2016). Genetic Syndromes, Maternal Diseases and Antenatal Factors Associated with Autism Spectrum Disorders (ASD). Frontiers in neuroscience. 10: 1-21.

Ozand, P. T., Al-odaib, A., Merza, H., & Al-harbi, S. (2003) Autism: a review, USA. Journal of Pediatric Neurology. 1(2): 55-67.

Parker-athill, E. C., & Tan, J. (2010). Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway. Neuro signals. 18 (2): 113-128.

Patterson, P. H. (2011). Maternal Infection and Immune Involvement in Autism. Trends Mol Med.17 (7): 389-394.

Pinto, M. M. V., Arisawa, E. A. L. S., Martins, R. A. B. L., & Raniero, L. J. (2021). Biomarcadores plasmáticos e salivares para diagnóstico precoce de Transtorno do Espectro Autista: revisão sistemática. Research, Society and Development, 10(10), e412101018924-e412101018924.

Previc, F. H. (2007). Prenatal influences on brain dopamine and their relevance to the rising incidence of autism. Medical Hypotheses. 68 (1): 46-60.

Rutter, M. (2005). An etiology of autism: findings and questions, UK. Journal of Intellectual Disability Research. 49 (4): 231-235.

São Paulo. (2011). Prefeitura Municipal de São Paulo. Escolaridade Materna e Acompanhamento Pré-Natal. Sistema de informação sobre Nascidos Vivos – SINASC/ Prefeitura Municipal de São Paulo.

Santos, M.S. (2015). Perturbações do Espetro do Autismo: Fatores de Risco e Protetores. 48f. Mestrado Integrado em Medicina / Instituto de Ciências Biomédicas Abel Salazar- Universidade do Porto. Porto.

Schetter, C. D. (2009).Stress process in pregnancy and preterm birth, Current Directions in Psychological Science. 18 (1): 205 - 209.

Schultz, S. T. (2010). Can autism be triggered by acetaminophen activation of the endocannabinoid system?. Acta Neurobiologiae Experimentalis. 70 (2): 227-231.

Silva, S. A., Lohmann, P. M., Da Costa, A. E. K., & Marchese, C. (2019). Conhecimento da equipe interprofissional acerca do autismo infantil. Research, Society and Development,8(9), e07891250.

Stern, M. (2011). Insulin signaling and autism. Frontiers in Endocrinology. 2: 1-2.

Volpe, J. J. (2009). Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neuro. 8 (1): 110-124.

Wang, C., Geng, H., Liu, W., & Zhang, G. (2017). Prenatal, perinatal, and postnatal factors associated with autism, China. Systematic Review and Meta-Analysis. 96 (18): 1-7.

Walker, C.K., Krakowiak, P., Baker, A., Hansen, R. L., Ozonoff, S., & Hertz-picciotto, I. (2015). Original Article: Preeclampsia, Placental Insufficiency and Autism Spectrum Disorder or Developmental Delay. JAMA Pediatrics. 169 (2): 154-162.

Walker, C. K., Anderson, K. W., Milano, K. M., Ye, S., Tancredi, D. J., Pessah, I. N., Hertz-Picciotto, I., & Kliman, H. J. (2013). Trophoblast Inclusions Are Significantly Increased in the Placentas of Children in Families at Risk for Autism. Biol Psychiatry.74 (3): 204-211.

Watanabe, M. A. E., Garcia, E. C. D., Carvalho, G. G., Matsubara, N. K., Ferreira, A. C. V., Zanluqui, N. G., & Oliveira, G. G. de. (2014). Pregnancy: an imune challenge. Ciências Biológicas e da Saúde. 35 (2): 147-162.

Wing, L., & Potter, D. (2002). The epidemiology of autistic spectrum disorders: is the prevalence rising?, Mental retardation and developmental disabilities Research reviews. 8 (3): 151-161.

Wu, S., Wu, F., Ding, Y., Hou, J., Bi, J., 7 Zhang, Z. (2017). Advanced parental age and autism risk in children: a systematic review and meta-analysis. Denmark, Acta Psychiatrica Scandinavica. 135 (x): 29-41.

Xu, G., Jing, J., Bowers, K., Liu, B., & Bao, W. (2014). Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis, USA. Journal of Autism Developmental Disorders. 44 (4): 766-775.

Yao, Y., Walsh, W. J., Mcginnis, W. R., & Pratico, D. (2006). Altered vascular phenotype in autism: correlation with oxidative stress. Archives of Neurology. 63 (8): 1161–1164.

Yap, I. K., Angley, M., Veselkov, K. A., Holmes, E., Lindon, J. C., & Nicholson, J. K. (2010). Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. Journal of Proteome Research. 9: 2996-3004.

Zenclussen, A. C., Fest, S., Busse, P., Joachim, R., Klapp, B. F., & Arck, P. C. (2002). Questioning the Th1/Th2 paradigm in reproduction: Peripheral levels of IL-12 are down-regulated in miscarriage patients. American Journal of Reproductive Immunology. 48 (4): 245-51.

Zerbo, O., Qian, Y., Yoshida, C., Grether, J. K., Water, J. V., & Croen, L. A. (2015). Maternal Infection during Pregnancy and Autism Spectrum Disorders, USA. Journal of Autism Developmental Disorders. 45 (12): 4015-4025.

Publicado

26/11/2022

Cómo citar

SANTOS, H. T. dos; SOUZA, L. P. de; PASSOS, A. da C. F. . Factores de riesgo gestacional en madres de niños diagnosticados con autismo. Research, Society and Development, [S. l.], v. 11, n. 15, p. e558111537837, 2022. DOI: 10.33448/rsd-v11i15.37837. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/37837. Acesso em: 18 may. 2024.

Número

Sección

Ciencias de la salud