Desarrollo, caracterización y evaluación por bioingeniería cutánea de una emulsión natural para proporcionar una base portadora estandarizada para preparaciones magistrales tópicas
DOI:
https://doi.org/10.33448/rsd-v11i16.38290Palabras clave:
Productos naturales; Farmacia de manipulación; Bioingeniería de la piel; Ensayo clínico.Resumen
O uso de produtos contendo substâncias naturais e sustentáveis tem mostrado um crescimento notável no mercado farmacêutico e cosmético, bem como na farmácia de manipulação. Este trabalho objetivou desenvolver, caracterizar e avaliar a bioengenharia cutânea de emulsões naturais e sustentáveis, proporcionando uma base veicular para preparações tópicas. Nove emulsões O/A foram desenvolvidas mudando a cera autoemulsionante não iônica (Cetearyl Olivate (and) Sorbitan Olivate, Cetearyl Glucoside (and) Cetearyl Alcohol, Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters (and) Glyceryl Stearate (and) Cetearyl Alcohol (and) Sodium Stearoyl Lactylate), with or without the anionic co-emulsifier (Sodium Stearoyl Glutamate), com ou sem o coemulsificante aniônico (Sodium Stearoyl Glutamate). Elas foram caracterizadas através de testes de estabilidade preliminar, reologia e estudo da estabilidade físico-química acelerada. Quatro formulações foram aprovadas (FB1, FB2, FB3 e FB5), mas apenas FB1 (Cetearyl Olivate (and) Sorbitan Olivate with Sodium Stearoyl Glutamate) foi considerada estável, sendo selecionada para a avaliação de eficácia de preservação, e para a bioengenharia cutânea. A hidratação e a perda de água transepidérmica (TEWL) do estrato córneo foram analisadas comparando com uma base veicular tópica convencional (Emulsifying Wax NF). O estudo clínico mostrou que FB1 melhorou a hidratação cutânea sem mudanças sifnificativas para o TEWL, mas demonstrou valores consideráveis. A FB1 pode ser classificada como “skin friendly” e representa um promissor veículo natural e sustentável para preparações farmacêuticas manipuladas.
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Derechos de autor 2022 Guilherme Carneiro Leal; Isabela Mazarim da Costa; Jéssica Bassi da Silva; Rafaela Said dos Santos; Marcos Luciano Bruschi; João Carlos Palazzo de Mello; Celso Vataru Nakamura; Audrey Alesandra Stinghen Garcia Lonni
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