Efeitos biológicos da naringenina e naringina: uma revisão de bioensaios

Fabio Correia Lima  Nepomuceno; Margareth de Fátima Formiga Melo  Diniz; José Maria  Barbosa Filho; Zilka Nanes  Lima; Fernanda Patrícia Torres  Barbosa; Mayara Karla dos Santos  Nunes; Hilzeth de Luna Freire Pessôa

doi:10.33448/rsd-v12i3.39232

Autores/as

Fabio Correia Lima Nepomuceno Federal University of Paraiba https://orcid.org/0000-0003-4879-3794
Margareth de Fátima Formiga Melo Diniz Federal University of Paraiba https://orcid.org/0000-0001-9896-9044
José Maria Barbosa Filho Federal University of Paraiba https://orcid.org/0000-0002-9567-4096
Zilka Nanes Lima Federal University of Paraiba https://orcid.org/0000-0002-1839-0348
Fernanda Patrícia Torres Barbosa Federal University of Paraiba https://orcid.org/0000-0002-5057-7372
Mayara Karla dos Santos Nunes Federal University of Paraiba https://orcid.org/0000-0001-9835-5050
Hilzeth de Luna Freire Pessôa Federal University of Paraiba https://orcid.org/0000-0002-7420-2014

DOI:

https://doi.org/10.33448/rsd-v12i3.39232

Palabras clave:

Naringenina; Naringina; Bioensayos; Actividad antibacterial.

Resumen

Actualmente, la búsqueda de compuestos antimicrobianos naturales se ha incrementado y, teniendo en cuenta la alta tasa de infección por microorganismos resistentes a los antibióticos, se ha estimulado la búsqueda de nuevos compuestos que tengan efecto antimicrobiano. Los flavonoides encajan en este grupo debido a sus fuertes propiedades biológicas y medicinales. Se informa que se produce actividad biológica como antiinflamatoria, antioxidante, antibacteriana, antihepatotóxica y anticancerígena. El objetivo del presente estudio fue recopilar información sobre la actividad antibacteriana in vitro de los flavonoides naringenina y naringina y demostrar los efectos biológicos de estas sustancias contra las bacterias. Esta es una revision integradora de la literatura sobre artículos científicos publicados entre 2017 y 2022 que se realizó utilizando las bases de datos PUMED. Los flavonoides pueden inhibir el crecimiento bacteriano a través de diferentes mecanismos, como el cambio de la permeabilidad de la membrana y la pared celular, la inhibición de la síntesis de ácidos nucleicos y también por la actividad sinérgica con los antibióticos. El desarrollo de nuevos fármacos antimicrobianos es cada vez más necesario, lo que convierte a los flavonoides en candidatos prometedores. Por lo tanto, se cree en el potencial de la naringenina y la naringina como fitoconstituyentes candidatos para el desarrollo e innovación de nuevos antibióticos.

Citas

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Efectos biológicos de la naringenina y la naringina: una revisión de los bioensayos

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