Análise prospectiva científica e tecnológica sobre o uso de bioinformática para o desenho de vacinas peptídicas

Luiz Natanael Monteiro Feitosa; Ítalo Samuel Gonçalves  Rodrigues; Tatiane Batista dos  Santos; Maria Patrícia de Jesus Santos; Rayssa do Couto  Santos; Tatiane de Oliveira Xavier Machado; Daniela Droppa-Almeida

doi:10.33448/rsd-v12i3.40287

Autores/as

Luiz Natanael Monteiro Feitosa Universidade Tiradentes https://orcid.org/0000-0002-2966-3727
Ítalo Samuel Gonçalves Rodrigues Universidade Tiradentes https://orcid.org/0000-0002-7053-2235
Tatiane Batista dos Santos Universidade Tiradentes https://orcid.org/0000-0002-5807-4614
Maria Patrícia de Jesus Santos Universidade Tiradentes https://orcid.org/0000-0002-6709-8597
Rayssa do Couto Santos Universidade Tiradentes https://orcid.org/0000-0002-5833-5685
Tatiane de Oliveira Xavier Machado Universidade Tiradentes https://orcid.org/0000-0002-7363-3752
Daniela Droppa-Almeida Universidade Tiradentes https://orcid.org/0000-0002-8154-1030

DOI:

https://doi.org/10.33448/rsd-v12i3.40287

Palabras clave:

Vacuna peptídica; Bioinformática; Vacuna de diseño.

Resumen

Las infecciones causadas por bacterias han tenido varios impactos negativos en la salud y la economía. Por su potencial de transmisibilidad, ha despertado un gran interés por parte de los científicos, ya que la mayoría de estos microorganismos son resistentes a los antibióticos y no cuentan con tratamientos y profilaxis eficaces. Por ello, la ciencia ha ido incorporando tecnologías de la información para analizar datos importantes con el fin de obtener información y así poder llevar a cabo el diseño de la vacuna contra estos patógenos. El objetivo de este estudio fue buscar en la literatura y en las invenciones, expedientes que estuvieran relacionados con vacunas peptídicas desarrolladas a partir del uso de la bioinformática. Vacuna peptídica, bioinformática y vacuna de diseño fueron las palabras clave utilizadas para la búsqueda de artículos y patentes en las siguientes bases de datos: PubMed, INPI y WIPO. El relevamiento de datos permitió encontrar una muestra de 259 artículos científicos y 31 patentes existentes en los últimos 11 años en la base de datos de la OMPI, además de 31 patentes en el INPI. La elaboración de prospectos científico-tecnológicos es de suma importancia ya que proporciona una mayor adquisición de conocimientos sobre el tema abordado y permite al científico orientar mejor el estudio.

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Análisis prospectivo científico y tecnológico sobre el uso de la bioinformática para el diseño de vacunas peptídicas

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