Análise prospectiva científica e tecnológica sobre o uso de bioinformática para o desenho de vacinas peptídicas

Luiz Natanael Monteiro Feitosa; Ítalo Samuel Gonçalves  Rodrigues; Tatiane Batista dos  Santos; Maria Patrícia de Jesus Santos; Rayssa do Couto  Santos; Tatiane de Oliveira Xavier Machado; Daniela Droppa-Almeida

doi:10.33448/rsd-v12i3.40287

Autores

Luiz Natanael Monteiro Feitosa Universidade Tiradentes https://orcid.org/0000-0002-2966-3727
Ítalo Samuel Gonçalves Rodrigues Universidade Tiradentes https://orcid.org/0000-0002-7053-2235
Tatiane Batista dos Santos Universidade Tiradentes https://orcid.org/0000-0002-5807-4614
Maria Patrícia de Jesus Santos Universidade Tiradentes https://orcid.org/0000-0002-6709-8597
Rayssa do Couto Santos Universidade Tiradentes https://orcid.org/0000-0002-5833-5685
Tatiane de Oliveira Xavier Machado Universidade Tiradentes https://orcid.org/0000-0002-7363-3752
Daniela Droppa-Almeida Universidade Tiradentes https://orcid.org/0000-0002-8154-1030

DOI:

https://doi.org/10.33448/rsd-v12i3.40287

Palavras-chave:

Peptide vaccine; Bioinformatics; Design vaccine.

Resumo

As infecções causadas por bactérias têm ocasionado diversos impactos negativos para a saúde e economia. Em virtude do seu potencial de transmissibilidade, vem despertando grande interesse dos cientistas, uma vez que grande parte desses microrganismos apresentam resistência a antibióticos e não possuem tratamentos e profilaxia eficazes. Diante disso, a ciência vem agregando a informática para analisar dados importantes na intenção de obter informações, e assim conseguir realizar o desenho vacinal contra esses patógenos. O objetivo desse estudo foi buscar na literatura e em invenções, os arquivos que estivessem relacionados a vacinas peptídicas desenvolvidas a partir do uso da bioinformática. Peptide vaccine, bioinformatics e design vaccine foram as palavras-chave utilizadas para a busca de artigos e patentes nas seguintes bases de dados: PubMed, INPI e WIPO. O levantamento de dados permitiu encontrar uma amostra de 259 artigos científicos e 31 patentes existentes nos últimos 11 anos na base da WIPO, além de 31 patentes na INPI. A elaboração de prospecções científico-tecnológicas é de extrema importância por proporcionar uma maior aquisição de conhecimento acerca da temática abordada e permitir ao cientista um melhor direcionamento do estudo.

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Análise prospectiva científica e tecnológica sobre o uso de bioinformática para o desenho de vacinas peptídicas

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