Posibles interacciones farmacológicas entre las plantas medicinales RENISUS y los fármacos de la terapia antirretrovírica del VIH

Autores/as

DOI:

https://doi.org/10.33448/rsd-v12i7.42636

Palabras clave:

Planta; Interacciones medicamentosas; VIH.

Resumen

El uso de plantas medicinales como alternativa de tratamiento complementario es muy común en la sociedad, incluso entre las personas que viven con el VIH. Existen estudios que abordan interacciones clínicamente significativas con fármacos antirretrovirales, aumentando el riesgo de resultados negativos como toxicidad o pérdida de control virológico. Por ello, nos propusimos realizar un estudio sobre las plantas de RENISUS que pueden interactuar con los antirretrovirales utilizados para tratar la infección por VIH y causar efectos perjudiciales. Encontramos 18 especies de plantas con posible interacción farmacológica con los antirretrovirales del VIH. Este estudio aporta pruebas científicas sobre las posibles interacciones entre los fármacos contra el VIH y las plantas medicinales, lo que contribuye a ampliar la atención colectiva e individual a las personas con enfermedades crónicas, como las personas que viven con el VIH/SIDA y siguen un tratamiento antirretroviral.

Biografía del autor/a

Adenilson Pereira Galvão Filho, Universidade Federal do Maranhão

Curso de Farmácia, Universidade Federal do Maranhão

Yuri Sandro Lima de Azevedo, Universidade Federal do Maranhão

Curso de Enfermagem, Universidade Federal do Maranhão

Keyliane Santos Lima, Universidade Federal do Maranhão

Curso de Enfermagem, Universidade Federal do Maranhão

Silvia Cristina Viana Silva Lima, Universidade Federal do Maranhão

Docente do Departamento de Saúde Pública, Universidade Federal do Maranhão

Citas

Ashafa A. T. O., Sunmonu T. O., Abass A. A., & Ogbe A. A. (2011). Laxative potential of the ethanolic leaf extract of Aloe vera (L.) Burm. f. in Wistar rats with loperamide-induced constipation. Journal of Natural Pharmaceuticals; 2(3), 158-162. 10.4103/2229-5119.86268

Block, K. I., & Mead, M. N. (2003). Immune System Effects of Echinacea, Ginseng, and Astragalus: A Review. Integrative Cancer Therapies, 2(3), 247–267. https://doi.org/10.1177/1534735403256419

Castro, M. R., & Figueiredo, F. F. (2019). Saberes tradicionais, biodiversidade, práticas integrativas e complementares: o uso de plantas medicinais no SUS. Hygeia - Revista Brasileira de Geografia Médica e da Saúde, 15(31), 56–70. https://doi.org/10.14393/hygeia153146605

Chang, B. L., van Servellen, G., & Lombardi, E. (2003). Factors Associated with Complementary Therapy Use in People Living with HIV/AIDS Receiving Antiretroviral Therapy. The Journal of Alternative and Complementary Medicine, 9(5), 695–710. https://doi.org/10.1089/107555303322524544

Chaves R. C., & Lima R. A. (2020). Um Estudo Bibliográfico Sobre Plantas Medicinais Utilizadas No Tratamento Hiv/Aids. Educamazônia-Educação, Sociedade e Meio Ambiente.; 20(1),91-112. Disponível em: https://periodicos.ufam.edu.br/index.php/educamazonia/article/view/7668

Cordeiro, C. H. G., Chung, M. C., & Sacramento, L. V. S. do. (2005). Interações medicamentosas de fitoterápicos e fármacos: Hypericum perforatum e Piper methysticum. Revista Brasileira de Farmacognosia, 15(3), 272–278. https://doi.org/10.1590/s0102-695x2005000300019

de Maat, M. M. R., Hoetelmans, R. M. W., Mathôt, R. A. A., van Gorp, E. C. M., Meenhorst, P. L., Mulder, J. W., & Beijnen, J. H. (2001). Drug interaction between St John’s wort and nevirapine. AIDS, 15(3), 420–421. https://doi.org/10.1097/00002030-200102160-00019

DiCenzo, R., Shelton, M., Jordan, K., Koval, C., Forrest, A., Reichman, R., & Morse, G. (2003). Coadministration of Milk Thistle and Indinavir in Healthy Subjects. Pharmacotherapy, 23(7), 866–870. https://doi.org/10.1592/phco.23.7.866.32723

Gurley, B. J., Barone, G. W., Williams, D. K., Carrier, J., Breen, P., Yates, C. R., Song, P., Hubbard, M. A., Tong, Y., & Cheboyina, S. (2005). Effect of Milk Thistle (Silybum Marianum) and Black Cohosh (Cimicifuga Racemosa) Supplementation on Digoxin Pharmacokinetics in Humans. Drug Metabolism and Disposition, 34(1), 69–74. https://doi.org/10.1124/dmd.105.006312

Hakkola J., Hukkanen J., Turpeinen M., & Pelkonen O. (2020) Inhibition and induction of CYP enzymes in humans: An update. Archives of Toxicology; 94(11), 3671-3722. https://doi.org/10.1007/s00204-020-02936-7

Haron, M. H., Avula, B., Gurley, B. J., Chittiboyina, A. G., Khan, I. A., & Khan, S. I. (2020). Possible Herb-Drug Interaction Risk of Some Nutritional and Beauty Supplements on Antiretroviral Therapy in HIV Patients. Journal of Dietary Supplements, 1–16. https://doi.org/10.1080/19390211.2020.1846658

Hu, Z., Yang, X., Ho, P. C. L., Chan, S. Y., Heng, P. W. S., Chan, E., Duan, W., Koh, H. L., & Zhou, S. (2005). Herb-Drug Interactions. Drugs, 65(9), 1239–1282. https://doi.org/10.2165/00003495-200565090-00005

Kehinde I., Khan R., Nlooto M., Gordon M. (2021). Modulatory influences of antiviral bioactive compounds on cell viability, mRNA and protein expression of cytochrome P450 3A4 and P-glycoprotein in HepG2 and HEK293. Cells. Bioorganic Chemistry; 107. https://doi.org/10.1016/j.bioorg.2020.104573

Kent, U. M., Aviram, M., Rosenblat, M., & Hollenberg, P. F. (2002). The Licorice Root Derived Isoflavan Glabridin Inhibits the Activities of Human Cytochrome P450S 3A4, 2B6, and 2C9. Drug Metabolism and Disposition, 30(6), 709–715. https://doi.org/10.1124/dmd.30.6.709

Ladenheim, D., Horn, O., Werneke, U., Phillpot, M., Murungi, A., Theobald, N., & Orkin, C. (2008). Potential health risks of complementary alternative medicines in HIV patients. HIV Medicine, 9(8), 653–659. https://doi.org/10.1111/j.1468-1293.2008.00610.x

Li Y., Meng Q., Yang M., Liu D., Hou X., Tang, L., & Bi H (2019). Current trends in drug metabolism and pharmacokinetics. Acta Pharmaceutica Sinica B.; 9(6), 1113-1144. https://doi.org/10.1016/j.apsb.2019.10.001

López Galera, R. M., Ribera Pascuet, E., Esteban Mur, J. I., Montoro Ronsano, J. B., & Juárez Giménez, J. C. (2008). Interaction between cat’s claw and protease inhibitors atazanavir, ritonavir and saquinavir. European Journal of Clinical Pharmacology, 64(12), 1235–1236. https://doi.org/10.1007/s00228-008-0551-1

Madabushi, R., Frank, B., Drewelow, B., Derendorf, H., & Butterweck, V. (2006). Hyperforin in St. John’s wort drug interactions. European journal of clinical pharmacology; 62(3), 225-233. https://doi.org/10.1007/s00228-006-0096-0

Mazzari, A. L. D. A., & Prieto, J. M. (2014). Herbal medicines in Brazil: pharmacokinetic profile and potential herb-drug interactions. Frontiers in Pharmacology, 5. https://doi.org/10.3389/fphar.2014.00162

Mncwangi, N., Chen, W., Vermaak, I., Viljoen, A. M., & Gericke, N. (2012). Devil’s Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens. Journal of Ethnopharmacology, 143(3), 755–771. https://doi.org/10.1016/j.jep.2012.08.013

Monera, T. G., Wolfe, A. R., Maponga, C. C., Benet, L. Z., & Guglielmo, J. (2008). Moringa oleifera leaf extracts inhibit 6β-hydroxylation of testosterone by CYP3A4. The Journal of Infection in Developing Countries, 2(05). https://doi.org/10.3855/jidc.201

Oga, E. F., Sekine, S., Shitara, Y., & Horie, T. (2015). Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences. European Journal of Drug Metabolism and Pharmacokinetics, 41(2), 93–108. https://doi.org/10.1007/s13318-015-0296-z

Piscitelli, S. C., Burstein, A. H., Welden, N., Gallicano, K. D., & Falloon, J. (2002). The effect of garlic supplements on the pharmacokinetics of saquinavir. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 34(2), 234–238. https://doi.org/10.1086/324351

Stolbach, A., Paziana, K., Heverling, H., & Pham, P. (2015). A Review of the Toxicity of HIV Medications II: Interactions with Drugs and Complementary and Alternative Medicine Products. Journal of Medical Toxicology, 11(3), 326–341. https://doi.org/10.1007/s13181-015-0465-0

Tanigawara, Y. (2000). Role of P-Glycoprotein in Drug Disposition. Therapeutic Drug Monitoring, 22(1), 137–140. https://doi.org/10.1097/00007691-200002000-00029

Tassotti Gelatti, G., De Oliveira, K. R., & Colet, C. de F. (2016). Potential drug interactions in relation with the use, medicine plants and herbal in premenopausal women period. Revista de Pesquisa Cuidado é Fundamental Online, 8(2), 4328–4346. https://doi.org/10.9789/2175-5361.2016.v8i2.4328-4346

Whittemorer, R., & Knaflk, K. (2005). The integrative review: updated methodology. Journal of Advanced Nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x.

Yan den Bout-van den Beukel, C. J. P., Koopmans, P. P., van der Ven, A. J. A. M., De Smet, P. A. G. M., & Burger, D. M. (2006). Possible Drug–Metabolism Interactions of Medicinal Herbs with Antiretroviral Agents. Drug Metabolism Reviews, 38(3), 477–514. https://doi.org/10.1080/03602530600754065

Publicado

02/08/2023

Cómo citar

COSTA, J. R. da S. .; GALVÃO FILHO, A. P. .; AZEVEDO, Y. S. L. de .; LIMA, K. S. .; LIMA, S. C. V. S. . Posibles interacciones farmacológicas entre las plantas medicinales RENISUS y los fármacos de la terapia antirretrovírica del VIH. Research, Society and Development, [S. l.], v. 12, n. 7, p. e18912742636, 2023. DOI: 10.33448/rsd-v12i7.42636. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/42636. Acesso em: 31 oct. 2024.

Número

Sección

Ciencias de la salud