Inmunologia de la Diabetes Mellitus tipo 1 y vías de glicooxidación relacinadas con la hiperglucemia
DOI:
https://doi.org/10.33448/rsd-v12i8.42986Palabras clave:
Diabetes Mellitus Tipo 1; Estrés oxidativo; Predisposición genética.Resumen
La Diabetes Mellitus tipo 1 (DM1) es una enfermedad autoinmune con una incidencia prevalente en la infância (aproximadamente entre los 10 y los 14 años), pero que puede desarrollarse en cualquier grupo etario. El conocimiento sobre la fisiopatología de la DM1 es amplio; sin embargo, todavía se necesitan artículos que aborden la respuesta inmune adaptativa desarrollada contra los autoantígenos y las consecuencias oxidativas del exceso de glucosa en el organismo. En esta revisión bibliográfica, el objetivo principal fue abordar las vías de inmunidad innata y adaptativa activadas durante el desarrollo de la DM1 y, después del desarrollo de la enfermedad, las vías alternativas de glicooxidación activadas ante el exceso de glucosa en el organismo. Para ello, se utilizaron plataformas de búsqueda como PubMed, Science Direct y Google Scholar. A través del conocimiento de estos dos procesos, es posible que se puedan diseñar nuevos métodos de tratamiento. Los mecanismos implicados en la formación de especies reactivas de oxígeno (ROS) pueden ser una valiosa herramienta en la búsqueda de nuevas dianas terapéuticas que tengan como objetivo reducir el riesgo de desarrollar patologías secundarias a la DM1.
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