Efecto del anetol y de la asociación anetol+itraconazol sobre la artritis experimental inducida por Paracoccidioides brasiliensis
DOI:
https://doi.org/10.33448/rsd-v13i3.45343Palabras clave:
Anetol; Itraconazol; Artritis infecciosa; Antifúngico.Resumen
En este estudio se evaluó el efecto del tratamiento con anetol (AN) y la combinación anetol+itraconazol (AN+IT) en comparación con IT, sobre la artritis séptica inducida por Paracoccidiodes brasiliensis. Los animales fueron tratados durante 14 días con dosis de anetol (AN - 62,5, 125 y 250 mg/kg), itraconazol (IT - 12,5, 25 y 50 mg/kg) y la combinación de anetol+itraconazol (AN+ IT - 62,5 y 12,5 mg/kg). Los parámetros evaluados fueron: el desarrollo del edema de rodilla, el número de leucocitos reclutados en la cavidad articular, el peso corporal de los animales, la capacidad para caminar, la concentración plasmática de óxido nítrico, la concentración de TNF en el exudado de la articulación de la rodilla, la producción de anticuerpos anti-Pb y la actividad de las transaminasas plasmáticas (AST y ALT). Los cambios histológicos en la articulación de la rodilla derecha de la pata trasera se evaluaron mediante tinción con hematoxilina-eosina y Grocott. Los resultados mostraron que el tratamiento con monoterapias y combinaciones redujo el edema de la articulación de la rodilla, el número de leucocitos reclutados en la cavidad sinovial y mejoró la marcha de los animales. La concentración de NO en plasma, TNF tisular y anti-Pb se redujo mediante el tratamiento con IT en todas las dosis probadas y con la combinación AN+IT. El tratamiento con AN sólo redujo la concentración plasmática de NO y TNF tisular en dosis altas. En conjunto, los datos mostraron que los tratamientos con monoterapia IT y la combinación de AN + IT mostraron un efecto inhibidor similar sobre el desarrollo de la artritis.
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Derechos de autor 2024 Edirlene Sara Wisniewski; Bruno Ambrósio da Rocha; Eduardo Alexandre Loth; Lucinéia de Fátima Chasko Ribeiro; Rose Meire Costa; Rinaldo Ferreira Gandra; Ciomar Aparecida Bersani Amado
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