Efeito do anetol e da associação anetol+itraconazol sobre a artrite experimental induzida por Paracoccidioides brasiliensis
DOI:
https://doi.org/10.33448/rsd-v13i3.45343Palavras-chave:
Anetol; Itraconazol; Artrite infecciosa; Antifúngico.Resumo
Neste estudo foi avaliado o efeito do tratamento com o anetol (AN) e a associação anetol+itraconazol (AN+IT) comparativamente ao IT, sobre a artrite séptica induzida pelo Paracoccidiodes brasiliensis. Os animais foram tratados por 14 dias nas doses de anetol (AN - 62,5, 125 e 250 mg/kg), itraconazol (IT - 12,5, 25 e 50 mg/kg) e associação de anetol+itraconazol (AN+IT - 62,5 e 12,5 mg/kg). Os parâmetros avaliados foram: o desenvolvimento do edema de joelho, o número de leucócitos recrutados na cavidade articular, o peso corporal dos animais, a capacidade de marcha, a concentração plasmática de óxido nítrico, a concentração de TNF no exsudato articular do joelho, a produção de anticorpos anti-Pb e a atividade de transaminases plasmáticas (AST e ALT). Alterações histológicas na articulação do joelho direito da pata posterior foram avaliadas utilizando coloração Hematoxilina-eosina e Grocott. Os resultados mostraram que o tratamento comas monoterapias e com a associação, reduziram o edema da articulação do joelho, o número de leucócitos recrutados na cavidade sinovial e melhoraram a marcha dos animais. A concentração de NO plasmática, de TNF tecidual e de anti-Pb foram reduzidos pelo tratamento com o IT em todas as doses testadas e com a associação AN+IT. O tratamento com AN somente reduziu a concentração plasmática de NO e de TNF tecidual em dose alta. No conjunto, os dados mostraram que os tratamentos com o IT em monoterapia e com a associação AN + IT, mostraram um efeito inibitório similar sobre o desenvolvimento da artrite.
Referências
Andrade, R. V., Da Silva, S. P., Torres, F. A., Poças-Fonseca, M. J., Silva-Pereira, I., Maranhão, A. Q., Campos, E. G., Moraes, L. M., Jesuíno, R. S., Pereira, M., Soares, C. M., Walter, M. E., Carvalho, M. J., Almeida, N. F., Brigido, M. M., & Felipe, M. S. (2005). Overview and perspectives the transcriptome of Paracoccidioides brasiliensis. Revista iberoamericana de micologia, 22(4), 203–212. https://doi.org/10.1016/s1130-1406(05)70044-9
Andrade, R. V., Paes, H. C., Nicola, A. M., de Carvalho, M. J., Fachin, A. L., Cardoso, R. S., Silva, S. S., Fernandes, L., Silva, S. P., Donadi, E. A., Sakamoto-Hojo, E. T., Passos, G. A., Soares, C. M., Brígido, M. M., & Felipe, M. S. (2006). Cell organisation, sulphur metabolism and ion transport-related genes are differentially expressed in Paracoccidioides brasiliensis mycelium and yeast cells. BMC genomics, 7, 208. https://doi.org/10.1186/1471-2164-7-208
Bagagli, E., Bosco, S. M., Theodoro, R. C., & Franco, M. (2006). Phylogenetic and evolutionary aspects of Paracoccidioides brasiliensis reveal a long coexistence with animal hosts that explain several biological features of the pathogen. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases, 6(5), 344–351. https://doi.org/10.1016/j.meegid.2005.12.002
Barrett, M. P., & Croft, S. L. (2012). Management of trypanosomiasis and leishmaniasis. British medical bulletin, 104(1), 175–196. https://doi.org/10.1093/bmb/lds031
Behnsen, J., Narang, P., Hasenberg, M., Gunzer, F., Bilitewski, U., Klippel, N., Rohde, M., Brock, M., Brakhage, A. A., & Gunzer, M. (2007). Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLoS pathogens, 3(2), e13. https://doi.org/10.1371/journal.ppat.0030013
Bellmann, R., & Smuszkiewicz, P. (2017). Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients. Infection, 45(6), 737–779. https://doi.org/10.1007/s15010-017-1042-z
Bernardino, S., Pina, A., Felonato, M., Costa, T. A., Frank de Araújo, E., Feriotti, C., Bazan, S. B., Keller, A. C., Leite, K. R., & Calich, V. L. (2013). TNF-α and CD8+ T cells mediate the beneficial effects of nitric oxide synthase-2 deficiency in pulmonary paracoccidioidomycosis. PLoS neglected tropical diseases, 7(8), e2325. https://doi.org/10.1371/journal.pntd.0002325
Brunton, L. L., Chabner, B., & Knollmann, B. C. (2012). The Pharmacological Bases of Goodman & Gilman´s Therapeutics. McGraw Hill Brasil.
Chainy, G. B., Manna, S. K., Chaturvedi, M. M., & Aggarwal, B. B. (2000). Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Oncogene, 19(25), 2943–2950. https://doi.org/10.1038/sj.onc.1203614
Dąbrowska, M., Zielińska-Bliźniewska, H., Kwiatkowski, P., Łopusiewicz, Ł., Pruss, A., Kostek, M., Kochan, E., & Sienkiewicz, M. (2021). Inhibitory Effect of Eugenol and trans-Anethole Alone and in Combination with Antifungal Medicines on Candida albicans Clinical Isolates. Chemistry & biodiversity, 18(5), e2000843. https://doi.org/10.1002/cbdv.202000843
Domiciano, T. P., Dalalio, M. M., Silva, E. L., Ritter, A. M., Estevão-Silva, C. F., Ramos, F. S., Caparroz-Assef, S. M., Cuman, R. K., & Bersani-Amado, C. A. (2013). Inhibitory effect of anethole in nonimmune acute inflammation. Naunyn-Schmiedeberg's archives of pharmacology, 386(4), 331–338. https://doi.org/10.1007/s00210-012-0820-5
Eyles, J. L., Roberts, A. W., Metcalf, D., & Wicks, I. P. (2006). Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease. Nature clinical practice. Rheumatology, 2(9), 500–510. https://doi.org/10.1038/ncprheum0291
Fujita, K., Tatsumi, M., Ogita, A., Kubo, I., & Tanaka, T. (2014). Anethole induces apoptotic cell death accompanied by reactive oxygen species production and DNA fragmentation in Aspergillus fumigatus and Saccharomyces cerevisiae. The FEBS journal, 281(4), 1304–1313. https://doi.org/10.1111/febs.12706
Fujita, K. I., Ishikura, T., Jono, Y., Yamaguchi, Y., Ogita, A., Kubo, I., & Tanaka, T. (2017). Anethole potentiates dodecanol's fungicidal activity by reducing PDR5 expression in budding yeast. Biochimica et biophysica acta. General subjects, 1861(2), 477–484. https://doi.org/10.1016/j.bbagen.2016.09.010
González, A., & Cano, L. E. (2001). Participación del polimorfonuclear neutrófilo en la respuesta inmune contra Paracoccidioides brasiliensis. Biomédica, 21(3), 264–74. https://doi.org/10.7705/biomedica.v21i3.1117
González, A., Sahaza, J. H., Ortiz, B. L., Restrepo, A., & Cano, L. E. (2003). Production of pro-inflammatory cytokines during the early stages of experimental Paracoccidioides brasiliensis infection. Medical mycology, 41(5), 391–399. https://doi.org/10.1080/13693780310001610038
GROCOTT R. G. (1955). A stain for fungi in tissue sections and smears using Gomori's methenamine-silver nitrate technic. American journal of clinical pathology, 25(8), 975–979. https://doi.org/10.1093/ajcp/25.8_ts.0975
Gunzer M. (2014). Traps and hyper inflammation - new ways that neutrophils promote or hinder survival. British journal of haematology, 164(2), 189–199. https://doi.org/10.1111/bjh.12608
Kim, D. K., Lillehoj, H. S., Lee, S. H., Jang, S. I., Park, M. S., Min, W., Lillehoj, E. P., & Bravo, D. (2013). Immune effects of dietary anethole on Eimeria acervulina infection. Poultry science, 92(10), 2625–2634. https://doi.org/10.3382/ps.2013-03092
Köhler, A., De Filippo, K., Hasenberg, M., van den Brandt, C., Nye, E., Hosking, M. P., Lane, T. E., Männ, L., Ransohoff, R. M., Hauser, A. E., Winter, O., Schraven, B., Geiger, H., Hogg, N., & Gunzer, M. (2011). G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands. Blood, 117(16), 4349–4357. https://doi.org/10.1182/blood-2010-09-308387
Kosalec, I., Pepeljnjak, S., & Kustrak, D. (2005). Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae). Acta pharmaceutica (Zagreb, Croatia), 55(4), 377–385.
Kumar, V., & Sharma, A. (2010). Neutrophils: Cinderella of innate immune system. International immunopharmacology, 10(11), 1325–1334. https://doi.org/10.1016/j.intimp.2010.08.012
Kunz, R. I., Coradini, J. G., Silva, L. I., Bertolini, G. R., Brancalhão, R. M., & Ribeiro, L. F. (2014). Effects of immobilization and remobilization on the ankle joint in Wistar rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 47(10), 842–849. https://doi.org/10.1590/1414-431x20143795
Loth, E. A., Biazin, S. K., Paula, C. R., Simão, R.deC, de Franco, M. F., Puccia, R., & Gandra, R. F. (2012). Experimental model of arthritis induced by Paracoccidioides brasiliensis in rats. Mycopathologia, 174(3), 187–191. https://doi.org/10.1007/s11046-012-9537-8
Loth, E. A., Biazim, S. K., Dos Santos, J. H., Puccia, R., Brancalhão, R. C., Chasco, L.deF., Gandra, R. F., Simão, R.deC., & de Franco, M. F. (2014). Dose response effect of Paracoccidioides brasiliensis in an experimental model of arthritis. Revista do Instituto de Medicina Tropical de Sao Paulo, 56(3), 259–264. https://doi.org/10.1590/s0036-46652014000300012
Martinez R. (2017). New Trends in Paracoccidioidomycosis Epidemiology. Journal of fungi (Basel, Switzerland), 3(1), 1. https://doi.org/10.3390/jof3010001
Mócsai A. (2013). Diverse novel functions of neutrophils in immunity, inflammation, and beyond. The Journal of experimental medicine, 210(7), 1283–1299. https://doi.org/10.1084/jem.20122220
Naranjo, M. S., Trujillo, M., Munera, M. I., Restrepo, P., Gomez, I., & Restrepo, A. (1990). Treatment of paracoccidioidomycosis with itraconazole. Journal of medical and veterinary mycology: bi-monthly publication of the International Society for Human and Animal Mycology, 28(1), 67–76. https://doi.org/10.1080/02681219080000091
Nathan C. (2006). Neutrophils and immunity: challenges and opportunities. Nature reviews. Immunology, 6(3), 173–182. https://doi.org/10.1038/nri1785
Nauseef W. M. (2007). How human neutrophils kill and degrade microbes: an integrated view. Immunological reviews, 219, 88–102. https://doi.org/10.1111/j.1600-065X.2007.00550.x
Nishikaku, A. S., Molina, R. F., Ribeiro, L. C., Scavone, R., Albe, B. P., Cunha, C. S., & Burger, E. (2009). Nitric oxide participation in granulomatous response induced by Paracoccidioides brasiliensis infection in mice. Medical microbiology and immunology, 198(2), 123–135. https://doi.org/10.1007/s00430-009-0113-x
Parente, A. F., Naves, P. E., Pigosso, L. L., Casaletti, L., McEwen, J. G., Parente-Rocha, J. A., & Soares, C. M. (2015). The response of Paracoccidioides spp. to nitrosative stress. Microbes and infection, 17(8), 575–585. https://doi.org/10.1016/j.micinf.2015.03.012
Park, K. S., Choi, J. J., Kim, W. U., Min, J. K., Park, S. H., & Cho, C. S. (2012). The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID). Clinical rheumatology, 31(2), 317–323. https://doi.org/10.1007/s10067-011-1818-y
Pino-Tamayo, P. A., Puerta-Arias, J. D., Lopera, D., Urán-Jiménez, M. E., & González, Á. (2016). Depletion of Neutrophils Exacerbates the Early Inflammatory Immune Response in Lungs of Mice Infected with Paracoccidioides brasiliensis. Mediators of inflammation, 2016, 3183285. https://doi.org/10.1155/2016/3183285
Ponte, E. L., Sousa, P. L., Rocha, M. V., Soares, P. M., Coelho-de-Souza, A. N., Leal-Cardoso, J. H., & Assreuy, A. M. (2012). Comparative study of the anti-edematogenic effects of anethole and estragole. Pharmacological reports: PR, 64(4), 984–990. https://doi.org/10.1016/s1734-1140(12)70895-2
Ramos, S. P., Sano, A., Ono, M. A., Camargo, Z. P., Estevão, D., Miyaji, M., Nishimura, K., & Itano, E. N. (2005). Antigenuria and antigenaemia in experimental murine paracoccidioidomycosis. Medical mycology, 43(7), 631–636. https://doi.org/10.1080/13693780400004786
Puerta-Arias, J. D., Pino-Tamayo, P. A., Arango, J. C., & González, Á. (2016). Depletion of Neutrophils Promotes the Resolution of Pulmonary Inflammation and Fibrosis in Mice Infected with Paracoccidioides brasiliensis. PloS one, 11(9), e0163985. https://doi.org/10.1371/journal.pone.0163985
Restrepo, A., McEwen, J. G., & Castañeda, E. (2001). The habitat of Paracoccidioides brasiliensis: how far from solving the riddle? Medical mycology, 39(3), 233–241. https://doi.org/10.1080/mmy.39.3.233.241
Restrepo, A., Cano, L. E., & Gonzalez, Á. (2015). The power of the small: the example of Paracoccidioides brasiliensis CONIDIA. Revista do Instituto de Medicina Tropical de Sao Paulo, 57 Suppl 19(Suppl 19), 5–10. https://doi.org/10.1590/S0036-46652015000700003
Ricci, G., Mota, F. T., Wakamatsu, A., Serafim, R. C., Borra, R. C., & Franco, M. (2004). Canine paracoccidioidomycosis. Medical mycology, 42(4), 379–383. https://doi.org/10.1080/1369378032000141417
Ricci-Azevedo, R., Gonçales, R. A., Roque-Barreira, M. C., & Girard, D. (2018). Human neutrophils are targets to paracoccin, a lectin expressed by Paracoccidioides brasiliensis. Inflammation research: official journal of the European Histamine Research Society ... [et al.], 67(1), 31–41. https://doi.org/10.1007/s00011-017-1093-8
Ritter, A. M., Domiciano, T. P., Verri, W. A., Jr, Zarpelon, A. C., da Silva, L. G., Barbosa, C. P., Natali, M. R., Cuman, R. K., & Bersani-Amado, C. A. (2013). Antihypernociceptive activity of anethole in experimental inflammatory pain. Inflammopharmacology, 21(2), 187–197. https://doi.org/10.1007/s10787-012-0152-6
Ritter, A. M. V., Hernandes, L., da Rocha, B. A., Estevão-Silva, C. F., Wisniewski-Rebecca, E. S., Cezar, J. D. S., Caparroz-Assef, S. M., Cuman, R. K. N., & Bersani-Amado, C. A. (2017). Anethole reduces inflammation and joint damage in rats with adjuvant-induced arthritis. Inflammation research: official journal of the European Histamine Research Society ... [et al.], 66(8), 725–737. https://doi.org/10.1007/s00011-017-1053-3
Rocha, F. F., Campos, M.G. (2007). Monoarthritis as manifestation of paracoccidioidomycoses. Pan-american jornal of infectology. 9(1), 31-33
Romagnolo, A. G., de Quaglia E Silva, J. C., Della Coletta, A. M., Gardizani, T. P., Martins, A. T. L., Romagnoli, G. G., Kaneno, R., de Campos Soares, A. M. V., De Faveri, J., & Dias-Melicio, L. A. (2018). Role of Dectin-1 receptor on cytokine production by human monocytes challenged with Paracoccidioides brasiliensis. Mycoses, 61(4), 222–230. https://doi.org/10.1111/myc.12725
Rosato, A., Vitali, C., De Laurentis, N., Armenise, D., & Antonietta Milillo, M. (2007). Antibacterial effect of some essential oils administered alone or in combination with Norfloxacin. Phytomedicine: international journal of phytotherapy and phytopharmacology, 14(11), 727–732. https://doi.org/10.1016/j.phymed.2007.01.005
Rosato, A., Vitali, C., Gallo, D., Balenzano, L., & Mallamaci, R. (2008). The inhibition of Candida species by selected essential oils and their synergism with amphotericin B. Phytomedicine: international journal of phytotherapy and phytopharmacology, 15(8), 635–638. https://doi.org/10.1016/j.phymed.2008.05.001
Sabry, B. A., Farouk, A., & Badr, A. N. (2021). Bioactivity evaluation for volatiles and water extract of commercialized star anise. Heliyon, 7(8), e07721. https://doi.org/10.1016/j.heliyon.2021.e07721
Sergejeva, S., & Lindén, A. (2009). Impact of IL-17 on cells of the monocyte lineage in health and disease. Endocrine, metabolic & immune disorders drug targets, 9(2), 178–186. https://doi.org/10.2174/187153009788452444
Shikanai-Yasuda, M. A., Mendes, R. P., Colombo, A. L., Telles, F. Q., Kono, A., Paniago, A. M. M., Nathan, A., Valle, A. C. F. D., Bagagli, E., Benard, G., Ferreira, M. S., Teixeira, M. M., Vergara, M. L. S., Pereira, R. M., Cavalcante, R. S., Hahn, R., Durlacher, R. R., Khoury, Z., Camargo, Z. P., Moretti, M. L., Martinez, R. (2018). II Consenso Brasileiro em Paracoccidioidomicose - 2017 [Brazilian guidelines for the clinical management of paracoccidioidomycosis]. Epidemiologia e servicos de saude: revista do Sistema Unico de Saude do Brasil, 27(spe), e0500001. https://doi.org/10.5123/S1679-49742018000500001
Shukla, H. S., Tripathi, S. G. (1987). Antifungal substance in the essential oil of Anise (Pimpinella anisum L.). Agricultural and Biological Chemistry, 51(7), 1991-1993. https://doi.org/10.1080/00021369.1987.10868311
Singh S. (2007). From exotic spice to modern drug? Cell, 130(5), 765–768. https://doi.org/10.1016/j.cell.2007.08.024
Sung, Y. Y., & Kim, H. K. (2013). Illicium verum extract suppresses IFN-γ-induced ICAM-1 expression via blockade of JAK/STAT pathway in HaCaT human keratinocytes. Journal of ethnopharmacology, 149(3), 626–632. https://doi.org/10.1016/j.jep.2013.07.013
Torres, I., Hernandez, O., Tamayo, D., Muñoz, J. F., Leitão, N. P., Jr, García, A. M., Restrepo, A., Puccia, R., & McEwen, J. G. (2013). Inhibition of PbGP43 expression may suggest that gp43 is a virulence factor in Paracoccidioides brasiliensis. PloS one, 8(7), e68434. https://doi.org/10.1371/journal.pone.0068434
Tsuda, Y., Takahashi, H., Kobayashi, M., Hanafusa, T., Herndon, D. N., & Suzuki, F. (2004). Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus. Immunity, 21(2), 215–226. https://doi.org/10.1016/j.immuni.2004.07.006
Ueda, Y., Tahara, Y. O., Miyata, M., Ogita, A., Yamaguchi, Y., Tanaka, T., & Fujita, K. I. (2021). Involvement of a Multidrug Efflux Pump and Alterations in Cell Surface Structure in the Synergistic Antifungal Activity of Nagilactone E and Anethole against Budding Yeast Saccharomyces cerevisiae. Antibiotics (Basel, Switzerland), 10(5), 537. https://doi.org/10.3390/antibiotics10050537
Visbal, G., San-Blas, G., Murgich, J., & Franco, H. (2005). Paracoccidioides brasiliensis, paracoccidioidomycosis, and antifungal antibiotics. Current drug targets. Infectious disorders, 5(3), 211–226. https://doi.org/10.2174/1568005054880118
Wagner, G., Moertl, D., Glechner, A., Mayr, V., Klerings, I., Zachariah, C., Van den Nest, M., Gartlehner, G., & Willinger, B. (2021). Paracoccidioidomycosis Diagnosed in Europe-A Systematic Literature Review. Journal of fungi (Basel, Switzerland), 7(2), 157. https://doi.org/10.3390/jof7020157
Wisniewski-Rebecca, E. S., Rocha, B. A., Wiirzler, L. A., Cuman, R. K., Velazquez-Martinez, C. A., & Bersani-Amado, C. A. (2015). Synergistic effects of anethole and ibuprofen in acute inflammatory response. Chemico-biological interactions, 242, 247–253. https://doi.org/10.1016/j.cbi.2015.10.013
Yang, J. F., Yang, C. H., Chang, H. W., Yang, C. S., Wang, S. M., Hsieh, M. C., & Chuang, L. Y. (2010). Chemical composition and antibacterial activities of Illicium verum against antibiotic-resistant pathogens. Journal of medicinal food, 13(5), 1254–1262. https://doi.org/10.1089/jmf.2010.1086
Yutani, M., Hashimoto, Y., Ogita, A., Kubo, I., Tanaka, T., & Fujita, K. (2011). Morphological changes of the filamentous fungus Mucor mucedo and inhibition of chitin synthase activity induced by anethole. Phytotherapy research: PTR, 25(11), 1707–1713. https://doi.org/10.1002/ptr.3579
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2024 Edirlene Sara Wisniewski; Bruno Ambrósio da Rocha; Eduardo Alexandre Loth; Lucinéia de Fátima Chasko Ribeiro; Rose Meire Costa; Rinaldo Ferreira Gandra; Ciomar Aparecida Bersani Amado
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
1) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
2) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
3) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.
