¿El ozono es efectivo para reducir dolor, edema y trismo tras una cirugía de tercer molar? Una revisión sistémica

Autores/as

DOI:

https://doi.org/10.33448/rsd-v9i10.8407

Palabras clave:

Dolor; Edema; Ozono; Trismo.

Resumen

Este estudio tuvo como objetivo evaluar la eficacia del ozono como terapia complementaria en la reducción del dolor, edema y trismo tras la extracción del tercer molar inferior. El protocolo se registró en el PROSPERO. Se utilizaron seis bases de datos electrónicas (PubMed, Scopus, LILACS, SciELO, Embase y Web of Science). Solo ensayos clínicos aleatorizados fueron incluidos, sin restricción de año, idioma y estatus de publicación. La herramienta JBI se usó para evaluar el riesgo de sesgo. El abordaje GRADE analizó la certeza de las evidencias. La búsqueda generó 3.386 resultados, de los cuales solo tres artículos eran elegibles. Los estudios fueron publicados entre los años 2013 y 2017, originando una muestra de 133 pacientes. El ozono se usó en forma de gas o gel. Todos los estudios encontraron resultados significativos para la reducción del dolor tras uno, tres y siete días. El éxito en la reducción del trismo y edema varió entre los estudios. El risco de sesgo varió de moderado a bajo. Todos los resultados fueron clasificados como un nivel de certeza muy bajo. Apesar de presentar resultados favorables la para reducción del dolor, no hay evidencias suficientes para indicar el uso do ozono como terapia complementaria durante la exodoncia de terceros molares.

Citas

Ahmedi, J., Ahmedi, E., Sejfija, O., Agani, Z., & Hamiti, V. (2016). Efficiency of gaseous ozone in reducing the development of dry socket following surgical third molar extraction. European journal of dentistry, 10(3), 381–385.

Ajeti, N. N., Pustina-Krasniqi, T., & Apostolska, S. (2018). The Effect of Gaseous Ozone in Infected Root Canal. Open access Macedonian journal of medical sciences, 6(2), 389–396.

Azarpazhooh, A., Limeback, H., Lawrence, H. P., & Fillery, E. D. (2009). Evaluating the effect of an ozone delivery system on the reversal of dentin hypersensitivity: a randomized, double-blinded clinical trial. Journal of endodontics, 35(1), 1–9.

Balshem, H., Helfand, M., Schünemann, H. J., Oxman, A. D., Kunz, R., Brozek, J., Vist, G. E., Falck-Ytter, Y., Meerpohl, J., Norris, S., & Guyatt, G. H. (2011). GRADE guidelines: 3. Rating the quality of evidence. Journal of clinical epidemiology, 64(4), 401–406.

Barden, J., Edwards, J. E., McQuay, H. J., & Andrew Moore, R. (2004). Pain and analgesic response after third molar extraction and other postsurgical pain. Pain, 107(1-2), 86–90.

Bianco, E., Maddalone, M., Porcaro, G., Amosso, E., & Baldoni, M. (2019). Treatment of Osteoradionecrosis of the Jaw with Ozone in the Form of Oil-based Gel: 1-year follow-up. The journal of contemporary dental practice, 20(2), 270–276.

Bittencourt, M. A., Paranhos, L. R., & Martins-Filho, P. R. (2017). Low-level laser therapy for treatment of neurosensory disorders after orthognathic surgery: A systematic review of randomized clinical trials. Medicina oral, patologia oral y cirugia bucal, 22(6), 780–787.

Bocci V. (2004). Ozone as Janus: this controversial gas can be either toxic or medically useful. Mediators of inflammation, 13(1), 3–11.

Bocci V. A. (2006). Scientific and medical aspects of ozone therapy. State of the art. Archives of medical research, 37(4), 425–435.

Bocci, V., Borrelli, E., Zanardi, I., & Travagli, V. (2015). The usefulness of ozone treatment in spinal pain. Drug design, development and therapy, 9, 2677–2685.

Cho, H., Lynham, A. J., & Hsu, E. (2017). Postoperative interventions to reduce inflammatory complications after third molar surgery: review of the current evidence. Australian dental journal, 62(4), 412–419.

Chuang, S. K., Perrott, D. H., Susarla, S. M., & Dodson, T. B. (2008). Risk factors for inflammatory complications following third molar surgery in adults. Journal of oral and maxillofacial surgery, 66(11), 2213–2218.

Doğan, M., Ozdemir Doğan, D., Düger, C., Ozdemir Kol, I., Akpınar, A., Mutaf, B., & Akar, T. (2014). Effects of high-frequency bio-oxidative ozone therapy in temporomandibular disorder-related pain. Medical principles and practice, 23(6), 507–510.

Domb W. C. (2014). Ozone therapy in dentistry. A brief review for physicians. Interventional neuroradiology, 20(5), 632–636.

Dray A. (1995). Inflammatory mediators of pain. British journal of anaesthesia, 75(2), 125–131.

Elvis, A. M., & Ekta, J. S. (2011). Ozone therapy: A clinical review. Journal of natural science, biology, and medicine, 2(1), 66–70.

Feslihan, E., & Eroğlu, C. N. (2019). Can Photobiomodulation Therapy Be an Alternative to Methylprednisolone in Reducing Pain, Swelling, and Trismus After Removal of Impacted Third Molars?. Photobiomodulation, photomedicine, and laser surgery, 37(11), 700–705.

Fitzpatrick, E., Holland, O. J., & Vanderlelie, J. J. (2018). Ozone therapy for the treatment of chronic wounds: A systematic review. International wound journal, 15(4), 633–644.

Henman, M. C., Leach, G. D., & Naylor, I. L. (1979). Production of prostaglandin-like materials by rat tail skin in response to injury [proceedings]. British journal of pharmacology, 66(3), 448P.

Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J. (2019). Cochrane Handbook for Systematic Reviews of Interventions version 6.0. Retrieved from https://training.cochrane.org/cochrane-handbook-systematic-reviews-interventions

Kazancioglu, H. O., Ezirganli, S., & Demirtas, N. (2014). Comparison of the influence of ozone and laser therapies on pain, swelling, and trismus following impacted third-molar surgery. Lasers in medical science, 29(4), 1313–1319.

Kazancioglu, H. O., Kurklu, E., & Ezirganli, S. (2014). Effects of ozone therapy on pain, swelling, and trismus following third molar surgery. International journal of oral and maxillofacial surgery, 43(5), 644–648.

Kumar, V., Abbas, A. K., Fausto, N., Aster, J. C. (2009) Pathologic Basis of Disease, Professional Edition: Expert Consult-Online. Philadelphia: Elsevier.

Lago-Méndez, L., Diniz-Freitas, M., Senra-Rivera, C., Gude-Sampedro, F., Gándara Rey, J. M., & García-García, A. (2007). Relationships between surgical difficulty and postoperative pain in lower third molar extractions. Journal of oral and maxillofacial surgery, 65(5), 979–983.

Libonati, A., Di Taranto, V., Mea, A., Montemurro, E., Gallusi, G., Angotti, V., Nardi, R., Paglia, L., Marzo, G., & Campanella, V. (2019). Clinical antibacterial effectiveness Healozone Technology after incomplete caries removal. European journal of paediatric dentistry, 20(1), 73–78.

Lim, D., & Ngeow, W. C. (2017). A Comparative Study on the Efficacy of Submucosal Injection of Dexamethasone Versus Methylprednisolone in Reducing Postoperative Sequelae After Third Molar Surgery. Journal of oral and maxillofacial surgery, 75(11), 2278–2286.

McGrath, C., Comfort, M. B., Lo, E. C., & Luo, Y. (2003). Changes in life quality following third molar surgery--the immediate postoperative period. British dental journal, 194(5), 265–261.

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & Prisma Group (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS medicine, 6(7), e1000097.

Murad, M. H., Mustafa, R. A., Schünemann, H. J., Sultan, S., & Santesso, N. (2017). Rating the certainty in evidence in the absence of a single estimate of effect. Evidence-based medicine, 22(3), 85–87.

Osunde, O., Saheeb, B., & Bassey, G. (2014). Indications and risk factors for complications of lower third molar surgery in a nigerian teaching hospital. Annals of medical and health sciences research, 4(6), 938–942.

Pell, G., Gregory, G. (1933) Impacted mandibular third molars: Classification and Impacted mandibular third molars. Dental Digest, 39, 330–8.

Seidler, V., Linetskiy, I., Hubálková, H., Stanková, H., Smucler, R., & Mazánek, J. (2008). Ozone and its usage in general medicine and dentistry. A review article. Prague medical report, 109(1), 5–13.

Sivalingam, V. P., Panneerselvam, E., Raja, K. V., & Gopi, G. (2017). Does Topical Ozone Therapy Improve Patient Comfort After Surgical Removal of Impacted Mandibular Third Molar? A Randomized Controlled Trial. Journal of oral and maxillofacial surgery, 75(1), 51.e1–51.e9.

Smith, N. L., Wilson, A. L., Gandhi, J., Vatsia, S., & Khan, S. A. (2017). Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Medical gas research, 7(3), 212–219.

Taşdemir Z, Alkan BA, Albayrak H. Effects of Ozone Therapy on the Early Healing Period of Deepithelialized Gingival Grafts: A Randomized Placebo-Controlled Clinical Trial. J Periodontol. 2016;87(6), 663-671.

Tirelli, U., Cirrito, C., Pavanello, M., Piasentin, C., Lleshi, A., & Taibi, R. (2019). Ozone therapy in 65 patients with fibromyalgia: an effective therapy. European review for medical and pharmacological sciences, 23(4), 1786–1788.

Tufanaru, C., Munn, Z., Aromataris, E., Campbell, J., Hopp, L. (2020). Systematic reviews of effectiveness. Retrieved from https://synthesismanual.jbi.global

Walker, K., Perkins, M., & Dray, A. (1995). Kinins and kinin receptors in the nervous system. Neurochemistry international, 26(1), 1–26.

Wang J. (2018). Neutrophils in tissue injury and repair. Cell and tissue research, 371(3), 531–539.

Yuasa, H., & Sugiura, M. (2004). Clinical postoperative findings after removal of impacted mandibular third molars: prediction of postoperative facial swelling and pain based on preoperative variables. The British journal of oral & maxillofacial surgery, 42(3), 209–214.

Descargas

Publicado

17/09/2020

Cómo citar

SILVA, R. P. da; ALMEIDA, V. L. de .; VIEIRA, W. de A. .; ROCHA, F. S. .; HERVAL, Álex M. .; NASCIMENTO, G. G. .; FIGUEIREDO, C. E. .; PARANHOS, L. . R. . ¿El ozono es efectivo para reducir dolor, edema y trismo tras una cirugía de tercer molar? Una revisión sistémica. Research, Society and Development, [S. l.], v. 9, n. 10, p. e319108407, 2020. DOI: 10.33448/rsd-v9i10.8407. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/8407. Acesso em: 17 jul. 2024.

Número

Sección

Revisiones