Revisão - O patógeno periodontal Treponema denticola: um fator de risco para aterosclerose

Autores

DOI:

https://doi.org/10.33448/rsd-v10i1.11637

Palavras-chave:

Treponema denticola; Doenças Periodontais; Aterosclerose.

Resumo

Objetivo: Treponema denticola “T. denticola” é um patógeno associado a doenças periodontais que apresenta capacidade de aderência, invasão e colonização dos tecidos do hospedeiro, o que permite alternar sua localização e danos em diferentes locais do corpo humano. Esta revisão tem por objetivo discutir diferentes estudos que detectaram T. denticola em placas ateroscleróticas, demonstrando a importância da doença periodontal na saúde sistêmica e a necessidade de explorar o desfecho dessa colonização além da cavidade oral. Metodologia: Cinquenta e cinco estudos foram identificados e agregados nesta revisão de acordo com os seguintes tópicos: Doença periodontal, aterosclerose e T. denticola. Estudos in vitro e in vivo publicados entre 2002 e 2020 foram pesquisados no PubMed, levantando insights relevantes sobre o papel do T. denticola e sua associação com a doença sistêmica, aterosclerose, focando na invasão bacteriana do tecido e o desenvolvimento da aterosclerose. Resultados: Após revisão bibliográfica, foi possível identificar estudos que demonstram a presença de T. denticola e outros patógenos orais em tecidos cardíacos ou vasculares e no soro sanguíneo, bem como, há pesquisas em que são apresentadas outras evidências de relação com a aterosclerose. Conclusão: A invasão de patógenos periodontais e suas toxinas associadas à resposta imune e inflamatória do hospedeiro podem contribuir para o desenvolvimento da aterosclerose.

Biografia do Autor

Patrícia Michelle Nagai de Lima, São Paulo State University

São Paulo State University (UNESP). Institute of Science and Technology. Department of Biosciences and Oral Diagnosis. São José dos Campos, SP, Brazil. 12245-000. 

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13/01/2021

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SANTOS, P. B. do R. E. dos .; LIMA, P. M. N. de .; PALMA, A. L. do R. .; HASNA, A. A. .; ROSSONI, R. D. .; JUNQUEIRA, J. C. .; OLIVEIRA, L. D. de . Revisão - O patógeno periodontal Treponema denticola: um fator de risco para aterosclerose. Research, Society and Development, [S. l.], v. 10, n. 1, p. e25810111637, 2021. DOI: 10.33448/rsd-v10i1.11637. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/11637. Acesso em: 17 jul. 2024.

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