Síntese, aplicações e Relação Estrutura-Atividade (REA) de derivados de ácido cinâmico: uma revisão
DOI:
https://doi.org/10.33448/rsd-v10i1.11691Palavras-chave:
Compostos fitoquímicos; Farmacológica; Química Farmacêutica; Técnicas de Síntese Química; Biossíntese.Resumo
O artigo tem por objetivo analisar o progresso da evolução dos derivados do ácido cinâmico por meio de uma revisão bibliográfica, descrevendo as principais rotas sintéticas na obtenção dessa classe, bem como as notáveis aplicações biológicas e aplicação da relação estrutura-atividade (SAR) como estratégia para projetar moléculas farmacologicamente ativas. A metodologia empregada consistiu na leitura e análise de artigos, cuja abordagem foi descritiva, sendo feito o levantamento de dados no que tange as potencialidades terapêuticas dos derivados do ácido cinâmico e sua relação estrutural, assim como as abordagens sintéticas mais utilizadas. Como resultado observou-se que o ácido cinâmico e seus derivados oriundos de fontes naturais podem ser sintetizados em quantidades apreciáveis por rotas sintéticas variadas, e que são bons candidatos a agentes terapêuticos, já que apresentam diversas aplicações terapêuticas contra diabetes, doenças infecciosas, degenerativas entre outras. Além disso, apresentam atividades como controle de pragas, o que vem chamando a atenção de pesquisadores do meio acadêmico e industrial. Esses compostos são altamente versáteis visto que sua atividade está intrinsecamente associada ao modo de interação entre a estrutura e seu alvo molecular. Contudo, na natureza são obtidos em pequenas quantidades, portanto, o desenvolvimento de novas abordagens de metodologias sintéticas visando obter tais compostos em quantidades substanciais e ligadas à química medicinal podem contribuir para o desenvolvimento de moléculas bioativas eficazes em comparação aos seus precursores.
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