Quais as estratégias de ventilação pulmonar na síndrome do desconforto respiratório agudo causada pela COVID-19? Um estudo de revisão

Autores

DOI:

https://doi.org/10.33448/rsd-v10i1.12037

Palavras-chave:

COVID-19; Betacoronavirus; Respiração artificial; Síndrome do desconforto respiratório do adulto.

Resumo

No final de 2019, emergiu um grupo de casos de pneumonia associados a um novo coronavírus de RNA envelopado, espalhando-se rapidamente pelos continentes e sendo rotulado como pandemia global por COVID-19. Uma proporção considerável da população doente não necessitará de hospitalização, entretanto, alguns pacientes podem desenvolver a forma grave da doença e apresentar complicações como a síndrome do desconforto respiratório agudo (SDRA), requerendo ventilação mecânica invasiva (VMI). Pacientes com SDRA por COVID-19 podem apresentar algumas características específicas em comparação com as formas típicas da síndrome, desenvolvendo fenótipos distintos que ainda tem sido estudados. As pesquisas têm, então, se concentrado em esclarecer estratégias ventilatórias protetoras do pulmão (EPP) para estes pacientes. Esta revisão narrativa teve como objetivo investigar a experiência mundial atual em relação à EPP como manejo da SDRA associada à COVID-19 e destacar considerações para as práticas de VMI durante a pandemia. Após um processo de rastreamento de estudos nas bases de dados PubMed e BVS, foram selecionados 20 estudos a serem analisados. Na maior parte dos estudos o manejo ventilatório dos pacientes se assemelhou ao da SDRA “clássica” e, portanto, a EPP destacou-se como importante aliada na regressão da SDRA nos pacientes COVID-19. No entanto, deve ser levado em consideração a heterogeneidade fenotípica dos pacientes, principalmente quanto à mecânica pulmonar e capacidade de recrutamento. Este estudo possibilitou aprofundamento cientifico sobre as semelhanças e diferenças da SDRA por COVID-19 e por outras causas, além de permitir a formação de orientações quanto aos ajustes ventilatórios iniciais em pacientes com SDRA/COVID-19.

Referências

Alhazzani, W., Møller, M. H., Arabi, Y. M., Loeb, M., Gong, M. N., Fan, E.,. & Rhodes, A. (2020). Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive care medicine, 1-34. https://doi.org/10.1007/s00134-020-06022-5

Amato, M. B., Meade, M. O., Slutsky, A. S., Brochard, L., Costa, E. L., Schoenfeld, D. A., & Brower, R. G. (2015). Driving pressure and survival in the acute respiratory distress syndrome. New England Journal of Medicine, 372(8), 747-755. https://doi.org//10.1056/NEJMsa1410639

Auld, S., Caridi-Scheible, M., Blum, J. M., Robichaux, C. J., Kraft, C. S., Jacob, J. T., & COVID, E. (2020). ICU and ventilator mortality among critically ill adults with COVID-19. medRxiv. https://doi.org/10.1101/2020.04.23.20076737

Barbas, C. S. V., Ísola, A. M., Farias, A. M. D. C., Cavalcanti, A. B., Gama, A. M. C., Duarte, A. C. M., & Amado, V. M. (2014). Recomendações brasileiras de ventilação mecânica 2013. Parte I. Revista Brasileira de terapia intensiva, 26(2), 89-121. https://doi.org/10.5935/0103-507X.20140017

Cavayas, Y. A., Noël, A., Brunette, V., Williamson, D., Frenette, A. J., Arsenault, C., & Albert, M. (2020). Early experience with critically ill patients with COVID-19 in Montreal. Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 1-10. https://doi.org/10.1007/s12630-020-01816-z

Chao, J. Y., Derespina, K. R., Herold, B. C., Goldman, D. L., Aldrich, M., Weingarten, J., & Medar, S. S. (2020). Clinical characteristics and outcomes of hospitalized and critically ill children and adolescents with coronavirus disease 2019 (COVID-19) at a Tertiary Care Medical Center in New York City. The Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2020.05.006

Cummings, M. J., Baldwin, M. R., Abrams, D., Jacobson, S. D., Meyer, B. J., Balough, E. M., & O'Donnell, M. R. (2020). Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study. The Lancet. https://doi.org/10.1016/S0140-6736(20)31189-2

De Prost, N., Ricard, J. D., Saumon, G., & Dreyfuss, D. (2011). Ventilator-induced lung injury: historical perspectives and clinical implications. Annals of intensive care, 1(1), 1-15. https://doi.org/10.1186/2110-5820-1-28

Derespina, K. R., Kaushik, S., Plichta, A., Conway Jr, E. E., Bercow, A., Choi, J., & Medar, S. S. (2020). Clinical manifestations and outcomes of critically ill children and adolescents with coronavirus disease 2019 in New York city. The Journal of pediatrics, 226, 55-63. https://doi.org/10.1016/j.jpeds.2020.07.039

Evrard, B., Goudelin, M., Montmagnon, N., Fedou, A. L., Lafon, T., & Vignon, P. (2020). Cardiovascular phenotypes in ventilated patients with COVID-19 acute respiratory distress syndrome. Critical Care, 24(1), 1-5. https://doi.org/10.1186/s13054-020-02958-8

Fan, E., Beitler, J. R., Brochard, L., Calfee, C. S., Ferguson, N. D., Slutsky, A. S., & Brodie, D. (2020). COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted?. The Lancet Respiratory Medicine. https://doi.org/10.1016/S2213-2600(20)30304-0

Ferrando, C., Suarez-Sipmann, F., Mellado-Artigas, R., Hernández, M., Gea, A., Arruti, E., & Villar, J. (2020). Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS. Intensive care medicine, 46(12), 2200-2211. https://doi.org/10.1007/s00134-020-06192-2

Gamberini, L., Tonetti, T., Spadaro, S., Zani, G., Mazzoli, C. A., Capozzi, C., & Ranieri, V. M. (2020). Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs. Journal of intensive care, 8(1), 1-12. https://doi.org/10.1186/s40560-020-00499-4

Garcia, P. D. W., Fumeaux, T., Guerci, P., Heuberger, D. M., Montomoli, J., Roche-Campo, F., & RISC-19-ICU Investigators. (2020). Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort. EClinicalMedicine, 25, 100449. https://doi.org/10.1016/j.eclinm.2020.100449

Gattinoni, L., Chiumello, D., Caironi, P., Busana, M., Romitti, F., Brazzi, L., & Camporota, L. (2020). COVID-19 pneumonia: different respiratory treatments for different phenotypes?. https://doi.org/10.1007/s00134-020-06033-2

Gattinoni, L., Coppola, S., Cressoni, M., Busana, M., Rossi, S., & Chiumello, D. (2020). Covid-19 does not lead to a “typical” acute respiratory distress syndrome. American journal of respiratory and critical care medicine, 201(10), 1299-1300. https://doi.org/10.1164/rccm.202003-0817LE

Ge, H., Pan, Q., Zhou, Y., Xu, P., Zhang, L., Zhang, J., & Zhang, Z. (2020). Lung Mechanics of Mechanically Ventilated Patients With COVID-19: Analytics With High-Granularity Ventilator Waveform Data. Frontiers in medicine, 7, 541. https://doi.org/10.3389/fmed.2020.00541

Grasselli, G., Greco, M., Zanella, A., Albano, G., Antonelli, M., Bellani, G., & Cecconi, M. (2020). Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy. JAMA internal medicine, 180(10), 1345-1355. https://doi.org/10.1001/jamainternmed.2020.3539

Grasselli, G., Zangrillo, A., Zanella, A., Antonelli, M., Cabrini, L., Castelli, A., & Pesenti, A. (2020). Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. Jama, 323(16), 1574-1581. https://doi.org/10.1001/jama.2020.5394

Hernandez-Romieu, A. C., Adelman, M. W., Hockstein, M. A., Robichaux, C. J., Edwards, J. A., Fazio, J. C., & Auld, S. C. (2020). Timing of intubation and mortality among critically ill coronavirus disease 2019 patients: a single-center cohort study. Critical care medicine. https:// doi.org/10.1097/CCM.0000000000004600

Kokoszka-Bargieł, I., Cyprys, P., Rutkowska, K., Madowicz, J., & Knapik, P. (2020). Intensive Care Unit Admissions During the First 3 Months of the COVID-19 Pandemic in Poland: A Single-Center, Cross-Sectional Study. Medical science monitor: international medical journal of experimental and clinical research, 26, e926974-1. https:// doi.org/10.12659/MSM.926974

Liu, X., Liu, X., Xu, Y., Xu, Z., Huang, Y., Chen, S., & Li, Y. (2020). Ventilatory Ratio in Hypercapnic Mechanically Ventilated Patients with COVID-19–associated Acute Respiratory Distress Syndrome. American journal of respiratory and critical care medicine, 201(10), 1297-1299. https://doi.org/10.1164/rccm.202002-0373LE

Mauri, T., Spinelli, E., Scotti, E., Colussi, G., Basile, M. C., Crotti, S., & Pesenti, A. (2020). Potential for lung recruitment and ventilation-perfusion mismatch in patients with the acute respiratory distress syndrome from coronavirus disease 2019. Critical Care Medicine. https://doi.org/10.1097/CCM.0000000000004386

Mittermaier, M., Pickerodt, P., Kurth, F., de Jarcy, L. B., Uhrig, A., Garcia, C., & Müller-Redetzky, H. (2020). Evaluation of PEEP and prone positioning in early COVID-19 ARDS. EClinicalMedicine, 28, 100579. https://doi.org/10.1016/j.eclinm.2020.100579

Monteiro, A. C., Suri, R., Emeruwa, I. O., Stretch, R. J., Cortes-Lopez, R. Y., Sherman, A., & Qadir, N. (2020). Obesity and smoking as risk factors for invasive mechanical ventilation in COVID-19: a retrospective, observational cohort study. PloS one, 15(12), e0238552. https://doi.org/10.1371/journal.pone.0238552

Pan, C., Chen, L., Lu, C., Zhang, W., Xia, J. A., Sklar, M. C., & Qiu, H. (2020). Lung Recruitability in COVID-19–associated Acute Respiratory Distress Syndrome: A Single-Center Observational Study. American journal of respiratory and critical care medicine, 201(10), 1294-1297. https://doi.org/10.1164/rccm.202003-0527LE

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., Shitsuka, R. 2018. Metodologia da pesquisa científica [e-book]. Santa Maria, RS. 1 Ed. UAB/NTE/UFSM

Pistillo, N., & Fariña, O. (2018). Driving airway and transpulmonary pressure are correlated to VILI determinants during controlled ventilation. Intensive care medicine, 44(5), 674-675. https://doi.org/10.1007/s00134-018-5092-1

Primmaz, S., Le Terrier, C., Suh, N., Ventura, F., Boroli, F., Bendjelid, K., & Pugin, J. (2020). Preparedness and reorganization of care for coronavirus disease 2019 patients in a swiss ICU: characteristics and outcomes of 129 patients. Critical care explorations, 2(8). https://doi.org/10.1097/CCE.0000000000000173

Saida, I. B., Ennouri, E., Nachi, R., Meddeb, K., Mahmoud, J., Thabet, N., & Boussarsar, M. (2020). Very severe COVID-19 in the critically ill in Tunisia. The Pan African Medical Journal, 35(Suppl 2). https://doi.org/10.11604/pamj.supp.2020.35.136.24753

Schmidt, M., Hajage, D., Demoule, A., Pham, T., Combes, A., Dres, M., & Grégoire, C. (2020). Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study. Intensive Care Medicine. https://doi.org/10.1007/s00134-020-06294-x

Slutsky, A. S., & Ranieri, V. M. (2014). Ventilator-induced lung injury. The New England journal of medicine, 370(10), 980-980. https://doi.org/10.1056/nejmc1400293

Turgut, T. E. K. E., KARS, T. U., & KOLLU, K. Ventilatory Management Strategies For Acute Respiratory Distress Syndrome (Ards) Due To Covid-19 Disease. Eurasian Journal of Critical Care, 2(2), 171-182.

Weiss, T. T., Cerda, F., Scott, J. B., Kaur, R., Sungurlu, S., Mirza, S. H., & Li, J. (2020). Prone positioning for patients intubated for severe acute respiratory distress syndrome (ARDS) secondary to COVID-19: a retrospective observational cohort study. British journal of anaesthesia. https://doi.org/10.1016/j.bja.2020.09.042

World Health Organization. (2020). WHO Coronavirus Disease (COVID-19) Dashboard. https://covid19.who.int/

Yang, X., Yu, Y., Xu, J., Shu, H., Liu, H., Wu, Y., & Shang, Y. (2020). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine. https://doi.org/10.1016/S2213-2600(20)30079-5

Yoshida, T., Fujino, Y., Amato, M. B., & Kavanagh, B. P. (2017). Fifty years of research in ARDS. Spontaneous breathing during mechanical ventilation. Risks, mechanisms, and management. American journal of respiratory and critical care medicine, 195(8), 985-992. https://doi.org/10.1164/rccm.201604-0748CP

Ziehr, D. R., Alladina, J., Petri, C. R., Maley, J. H., Moskowitz, A., Medoff, B. D., & Hardin, C. C. (2020). Respiratory pathophysiology of mechanically ventilated patients with COVID-19: a cohort study. American Journal of Respiratory and Critical Care Medicine, (ja). https://doi.org/10.1164/rccm.202004-1163LE

Bellani, G., Grassi, A., Sosio, S., Gatti, S., Kavanagh, B. P., Pesenti, A., & Foti, G. (2019). Driving pressure is associated with outcome during assisted ventilation in acute respiratory distress syndrome. Anesthesiology: The Journal of the American Society of Anesthesiologists, 131(3), 594-604. https://doi.org/10.1097/ALN.0000000000002846

Villar, J., Martín-Rodríguez, C., Domínguez-Berrot, A. M., Fernández, L., Ferrando, C., Soler, J. A., & Kacmarek, R. M. (2017). A quantile analysis of plateau and driving pressures: effects on mortality in patients with acute respiratory distress syndrome receiving lung-protective ventilation. Critical care medicine, 45(5), 843-850. https://doi.org/10.1097/CCM.0000000000002330

Force, A. D. T., Ranieri, V. M., Rubenfeld, G. D., Thompson, B. T., Ferguson, N. D., & Caldwell, E. (2012). Acute respiratory distress syndrome. Jama, 307(23), 2526-2533. https://doi.org/10.1001/jama.2012.5669

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28/01/2021

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OLIVEIRA, M. I. da S. .; BRANDÃO, C. B. F. .; COSTA, K. V. da .; SILVA, J. P. dos S. .; FERNANDES, V. M. de S. .; BRITO, G. E. G. de .; ELIHIMAS JÚNIOR, U. F. .; FRANÇA, E. E. T. de . Quais as estratégias de ventilação pulmonar na síndrome do desconforto respiratório agudo causada pela COVID-19? Um estudo de revisão. Research, Society and Development, [S. l.], v. 10, n. 1, p. e51110112037, 2021. DOI: 10.33448/rsd-v10i1.12037. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12037. Acesso em: 22 nov. 2024.

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