Efectos farmacológicos de la hidroxicloroquina en pacientes con COVID-19: Revisión sistemática de la literatura
DOI:
https://doi.org/10.33448/rsd-v10i8.17193Palabras clave:
Hidroxicloroquina; COVID-19; Coronavirus; Tratamiento.Resumen
Un brote del nuevo coronavirus (COVID-19) se inició en diciembre de 2019, y se extendió por toda China, extendiéndose al mundo en poco tiempo, lo que requiere búsquedas inmediatas para su tratamiento. Por lo tanto, el uso de cloroquina (CQ) e hidroxicloroquina (HCQ) ha despertado interés en COVID-19. Esta revisión sistemática sigue los elementos de informe indicados para las revisiones sistemáticas y las Pautas de metaanálisis (PRISMA). Los descriptores fueron seleccionados: “SARS-CoV-2”, “COVID-19”, “Hidroxicloroquina” y “Cloroquina” e incluidos en las bases de datos Science Direct, Biblioteca Nacional de Medicina de los Estados Unidos (PubMed), Información bibliográfica latinoamericana en salud. ciencias (LILACS), Scientific Electronic Library Online (SciELO) y Web of Science para la búsqueda de estudios. Después del cribado, se encontraron un total de 6.339 estudios. Después de leer y aplicar los criterios de elegibilidad, se seleccionaron un total de 8 artículos para preparar los resultados de esta revisión. Los resultados de los estudios mostraron que el uso de HCQ tiene resultados sin una mejora significativa en el cuadro clínico, incluida la asociación con eventos adversos (incluidos los graves) en pacientes con COVID-19. Por lo tanto, los ensayos clínicos aleatorizados no proporcionaron evidencia de la eficacia de HCQ en pacientes con COVID-19, lo que demuestra que un HCQ no es significativamente efectivo y tiene resultados negativos con respecto a su seguridad para pacientes con COVID-19.
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Derechos de autor 2021 Francisco Emanoel Alves de Araújo; João Matheus Caé da Rocha; Lucas Emmanuel Rocha de Moura Marques; Kellyson Lopes da Silva Macedo; Paloma Katlheen Moura Melo; Gabriella Mendes Duarte; Francisco Irochima Pinheiro; Fausto Pierdoná Guzen
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