Influência do Magnésio e Cálcio sobre o Estresse Oxidativo na Obesidade
DOI:
https://doi.org/10.33448/rsd-v9i1.1776Palavras-chave:
Deficiências Nutricionais; Metabolismo; Doenças Crônicas não Transmissíveis.Resumo
Introdução: A obesidade é caracterizada por excesso de gordura corporal decorrente do desequilíbrio entre a ingestão alimentar e gasto energético. Estudos têm demonstrado que o excesso de tecido adiposo se associa com estresse oxidativo em grau elevado. Outro aspecto importante, diz respeito às alterações nas concentrações de micronutrientes, a exemplo do magnésio e cálcio, em organismos obesos. Pesquisas têm destacado redução nos valores séricos desses minerais nesses indivíduos, bem como têm evidenciado que em situações de deficiência parece haver maior produção de espécies reativas de oxigênio, contribuindo para o estresse oxidativo. Portanto, a presente revisão objetiva trazer informações atualizadas sobre a relação existente entre magnésio, cálcio e estresse oxidativo na obesidade. Metodologia: Realizou-se um levantamento bibliográfico nas bases de dados Pubmed, SciELO e LILACS, utilizando as seguintes palavras-chave: “calcium”, “magnesium” e “obesity”; “obesity” e “oxidative stress”; “calcium”, “magnesium”, “obesity” e “oxidative stress”. Resultados: Os indivíduos obesos parecem apresentar deficiência de magnésio decorrente de uma ingestão inadequada do mineral, comprometendo mecanismos de defesa antioxidante, como também contribuindo para o aumento de cálcio intracelular, fator que acarreta uma produção elevada de espécies reativas de oxigênio, promovendo o estresse oxidativo. Conclusão: A inadequação no consumo de magnésio contribui para a manifestação de sua deficiência em obesos, situação que está atrelada a alterações no metabolismo do cálcio e no sistema de defesa antioxidante. No entando, mais estudos são necessários, considerando que o metabolismo dos micronutrientes estudados não estão completamente elucidados.
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