Avaliação da imunomarcação de Fibronectina e Tenascina induzida por cimentos biocerâmicos reparadores: estudo em tecido subcutâneo de ratos wistar
DOI:
https://doi.org/10.33448/rsd-v10i10.19325Palavras-chave:
Endodontia; Imuno-Histoquímica; Inflamação; Teste de Materiais; Tenascina.Resumo
O objetivo do estudo foi avaliar a presença de imunomarcadores fibronectina e tenascina em subcutâneo de rato com cimento reparador biocerâmico Biodentine®, quando comparado ao MTA Branco Angelus® e Ca(OH)2 . Foram implantados tubos de polietileno no subcutâneo de 32 ratos machos Wistar contendo os materiais e um tubo vazio para controle (n = 8 animais). Após os dias 7, 15, 30 e 60, os animais foram eutanasiados, os tubos de polietileno removidos com os tecidos circundantes e os espécimes foram preparados para análise de imunomarcação. Os dados foram analisados por meio do teste de Kruskal-Wallis e Dunn com nível de significância de 5%. Os materiais apresentaram moderado padrão de imunomarcação para fibronectina a partir de 7 dias e de tenascina a partir de 15 dias. O grupo Biodentine aos 60 dias foi o único que apresentou alto padrão de imunomarcação para as glicoproteínas. Conclui-se que o cimento Biodentine induziu maior padrão de imunomarcação de tenascina e fribronectina no período de 60 dias, e se igualando ao MTA e ao Ca(OH)2 nos outros períodos, mostrando resultados superiores aos outros materiais.
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Copyright (c) 2021 Diego Valentim; Carlos Roberto Emerenciano Bueno; Marina Tolomei Sandoval Cury; Ana Maria Veiga Vasques; Ana Claudia Rodrigues da Silva ; Francine Benetti; Gustavo Sivieri Araujo; Rogerio Castilho Jacinto; João Eduardo Gomes-Filho; Edilson Ervolino; Luciano Tavares Angelo Cintra; Eloi Dezan-Junior
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