Terapia fotodinâmica como adjuvante ao tratamento periodontal: revisão de literatura

Autores

DOI:

https://doi.org/10.33448/rsd-v10i13.21534

Palavras-chave:

Doenças Periodontais; Lasers; Fotoquimioterapia.; Doenças periodontais; Lasers; Fotoquimioterapia.

Resumo

A doença periodontal é um processo inflamatório crônico de caráter infeccioso que acomete os tecidos de suporte do dente, podendo levar à perda dentária. Atuando como adjuvante no tratamento de doenças periodontais, a terapia fotodinâmica tem ganhado visibilidade. Esse trabalho objetiva abordar a aplicação desse procedimento no tratamento periodontal, suas vantagens e desvantagens, indicações e contraindicações, conceito da técnica, materiais utilizados e resultados clínicos. A metodologia utilizada foi através de uma revisão de literatura, que foi conduzida por meio do acesso à base de dados PubMed e Portal Regional da BVS, com publicações selecionadas entre os anos 1993 e 2021, utilizando palavras chaves sobre o tema em questão. A técnica consiste na associação de uma fonte de luz e um fotossensibilizador, com a finalidade de promover morte microbiana, desinfecção e auxiliar no processo de cicatrização. Pesquisas confirmam diversas vantagens de sua aplicação na prática odontológica, como por exemplo a incapacidade de gerar resistência bacteriana e efeitos colaterais prejudiciais, promover ação localizada, custo acessível e facilidade de execução. Estudos demonstram a efetividade da terapia contra bactérias periodontopatogênicas e seus resultados positivos quando aplicada como auxiliar no tratamento periodontal, visto que permite a eliminação de patógenos retidos em áreas de furca, sulcos, concavidades, áreas distais dos molares e bolsas profundas, que por conta da limitação do tratamento mecânico, acabam permanecendo e recolonizando esses sítios.  A perspectiva futura é de que a terapia fotodinâmica ganhe mais espaço na atuação clínica, sendo um adjuvante promissor na obtenção de resultados satisfatórios na periodontia.

Referências

Allaker, R.P. & Douglas, C.W. (2009). Novel anti-microbial therapies for dental plaque-related diseases. The International Journal of Antimicrobial Agents, 33(1), 8-13.

Alvarenga, L.H., Prates, R.A., Yoshimurad, T.M., Katoe, I.T., Suzuki, L.C., Ribeiro, M.S., Ferreira, L.R., Pereira, S.A.S., Martinez, E.F. & Saba-Chujfia, E. (2015). Aggregatibacter actinomycetemcomitans biofilm can be inactivated by methylene blue-mediated photodynamic therapy. Photodiagnosis and Photodynamic Therapy, 12(1), 131-135.

Alwaeli, H.A., Al-Khateeb, S.N. & Al-Sadi, A. (2015). Long-term clinical effect of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial. Lasers in Medical Science, 30(2), 801-807.

Andersen, R., Loebel, N., Hammond, D. & Wilson, M. (2007). Treatment of periodontal disease by photodisinfection compared to scaling and root planing. The Journal of Clinical Dentistry, 18(2), 34-38.

Aoki, A, Sasaki, K.M., Watanabe, H. & Ishikawa, I. (2004). Laser in nonsurgical periodontal therapy. Periodontology 2000, 36(1), 59-97.

Araújo, N.C., Fontana, C.R., Gerbi, M.E.M. & Bagnato, V.S. (2012). Overall-mouth disinfection by photodynamic therapy using curcumin. Photomedicine and Laser Surgery, 30(2), 96-101.

Armitage, G.C. (1999). Development of a classification system for periodontal diseases and conditions. Annals of Periodontology, 4(1), 1-6.

Armitage, G.C., Cullinan, M.P. & Seymour, G.J. (2010). Comparative biology of chronic and aggressive periodontitis: introduction. Periodontology 2000, 53(1), 7-11.

Armitage, G.C. (2000). Periodontal infections and cardiovascular disease - how strong is the association? Oral Diseases, 6(6) 335-350.

Azarpazhooh, A., Shah, P.S., Tenenbaum, H.C. & Goldberg, M.B. (2010). The effect of photodynamic therapy for periodontitis: A systematic review and meta-analysis. Journal of Periodontology, 81(1), 4-14.

Bagnato, V.S. (2008). Novas técnicas óticas para as áreas da saúde. São Paulo: Editora Livraria da Física.

Betsy, J., Prasanth, C.S., Baiju, K.V., Prasanthila, J. & Subhash, N. (2014). Efficacy of antimicrobial photodynamic therapy in the management of chronic periodontitis: a randomized controlled clinical trial. Journal of Clinical Periodontology, 41(6), 573-581.

Bottura, P.E., Milanezi, J., Fernandes, L.A., Caldas, H.C., Abbud-Filho, M., Garcia, V.G. & Baptista, M.A.S.F. (2011). Nonsurgical periodontal therapy combined with laser and photodynamic therapies for periodontal disease in immunosuppressed rats. Transplantation Proceedings, 43(5), 2009-2016.

Braun, A., Dehn, C., Krause, F. & Jepsen, S. (2008) Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial. Journal of Clinical Periodontology, 35(10), 877-884.

Carrera, E.T, Dias H.B., Corbi, S.C.T., Marcantonio, R.A.C., Bernardi A.C.A., Bagnato V.S., Hamblin M.R. & Rastelli, A.N.S. (2016). The application of antimicrobial photodynamic therapy (aPDT) in dentistry: a critical review. Laser Physics, 26(12), 1-23.

Chambrone, L., Wang, H-L. & Romanos, G. (2018). Antimicrobial photodynamic therapy for the treatment of periodontitis and peri-implantitis: An American Academy of Periodontology best evidence review. Journal of Periodontology, 89(7), 783-803.

Chan, Y. & Lai, C.H. (2003). Bactericidal effects of different laser wavelengths on periodontopathic germs in photodynamic therapy. Lasers in Medical Science, 18(1), 51-55.

Christodoulides, N., Nikolidakis, D., Chondros, P., Becker, J., Schwarz, F., Rössler, R. & Sculean, A. (2008). Photodynamic therapy as an adjunct to nonsurgical periodontal treatment: a randomized, controlled clinical trial. Journal of Periodontology, 79(9), 1638-1644.

Cieplik, F., Deng, D., Crielaard, W., Buchalla, W., Hellwig, E., Al-Ahmad, A. & Maisch, T. (2018). Antimicrobial photodynamic therapy - what we know and what we don't. Critical Reviews in Microbiology, 44(5), 571-589.

Cieplik, F., Tabenski, L., Buchalla, W. & Maisch, T. (2014). Antimicrobial photodynamic therapy for inactivation of biofilms formed by oral key pathogens. Frontiers in Microbiology, 12(5), 405.

Cordeiro, A.M., De Oliveira, G.M., Rentería, J.M., Guimarães, C.A. (2007). Revisão sistemática: uma revisão narrativa. Revista do Colégio Brasileiro de Cirurgiões, 34(6), 428-431.

Dai, T., Huang, Y.Y. & Hamblin, M.R. (2009). Photodynamic therapy for localized infections--state of the art. Photodiagnosis and Photodynamic Therapy, 6(3-4), 170-188.

De Almeida, J.M., Theodoro, L.H., Bosco, A.F., Nagata, M.J.H., Oshiiwa, M. & Garcia, V.G. (2007). Influence of photodynamic therapy on the development of ligature-induced periodontitis in rats. Journal of Periodontology, 78(3), 566-575.

De Almeida, J.M., Theodoro, L.H., Bosco, A.F., Nagata, M.J.H., Bonfante, S., Garcia, V.G. (2008). Treatment of experimental periodontal disease by photodynamic therapy in rats with diabetes. Journal of Periodontology, 79(11), 2156-2165.

De Oliveira, R.R., Schwartz-Filho, H.O., Novaes-Jr, A.B. & Taba-Jr, M. (2009). Antimicrobial photodynamic therapy in the non-surgical tretment of aggressive periodontitis: a preliminary randomized controlled clinical study. Journal of Periodontology, 78(6), 965–973.

Dörtbudak, O., Haas, R., Bernhart, T. & Mailath-Pokorny, G. (2001). Lethal photosensitization for decontamination of implant surfaces in the treatment of peri-implantitis. Clinical Oral Implants Research, 12(2), 104-108.

Dovigo, L.N., Pavarina, A.C., Carmello, J.C., Machado, A.L., Brunetti, I.L. & Bagnato, V.S. (2011). Susceptibility of clinical isolates of Candida to photodynamic effects of curcumin. Laser Medicine & Surgery, 43(9), p.927-934.

Eduardo, C.P., Bello-Silva, M.S., Ramalho, K.M., Lee, E.M.R. & Aranha, A.C.C. (2015). A terapia fotodinâmica como benefício complementar na clínica odontológica. Revista da Associação Paulista de Cirurgiões Dentistas, 69(3), 226-235.

Eick, S., Markauskaite, G., Nietzsche, S., Laugisch, O., Salvi, G.E. & Sculean, A. (2013). Effect of photoactivated disinfection with a light-emitting diode on bacterial species and biofilms associated with periodontitis and peri-implantitis. Photodiagnosis and Photodynamic Therapy, 10(2), 156–167.

Feng, Z. & Weinberg, A. (2006). Role of bacteria in health and disease of periodontal tissues. Periodontology 2000, 40(1), 50-76.

Fernandes, L.A., Almeida, J.M., Theodoro, L.H., Bosco, A.F., Nagata, M.J.H., Martins, T.M., Okamoto, T. & Garcia, V.G. (2009). Treatment of experimental periodontal disease by photodynamic therapy in immunosuppressed rats. Journal Clinic of Periodontology, 36(3), 219-228.

Fernandes, L.A., Martins, T.M., Almeida, J.M., Theodoro, L.H. & Garcia, V.G. (2010). Radiographic assessment of photodynamic therapy as an adjunctive treatment on induced periodontitis in immunosuppressed rats. Journal of Applied Oral Science, 18(3), 237-43.

Flemming, T. F. (1999). Periodontitis. Annals of Periodontology, 4(1), 32-37.

Garcez, A.S., Nuñez, S.C., Hamblin, M.R. & Ribeiro, M.S. (2008). Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion. Journal of Endodontics, 34(2), 138-142.

Grossi, S.G., Skrepcinski, F.N., DeCaro, T., Zambon, J.J., Cummins, D. & Genco, R.J. (1996). Response to periodontal therapy in diabetics and smokers. Journal of Periodontology, 67(10), 1094-1102.

Hengzhuang, W., Wu, H., Ciofu, O., Song, Z. & Høiby, N. (2011). Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms. Antimicrobial Agents and Chemotherapy, 55(9), 4469-4474.

Huang, L., Dai, T. & Hamblin, M.R. (2010). Antimicrobial photodynamic inactivation and photodynamic therapy for infections. Methods in Molecular Biology, 3(5), 155-173.

Jori, G., Fabris, C., Soncin, M., Ferro, S., Coppellotti, O., Dei, D., Fantetti, L., Chiti, G. & Roncucci, G. (2006). Photodynamic therapy in the treatment of microbial infections: basic principles and perspective applications. Lasers in Surgery and Medicine, v. 38(5), 468-481.

Karmakova, T., Feofanov, A., Pankratov, A., Kazachkina, N., Nazarova, N., Yakubovskaya, R., Lebedeva, R., Ruziyev, R., Mironov, A., Maurizot, J.C. & Vigny, P. (2006). Tissue distribution and in vivo photosensitizing activity of 13,15-[N-(3-hydroxypropyl)]cycloimide chlorin p6 and 13,15-(N-methoxy)cycloimide chlorin p6 methyl ester. The Journal of Photochemistry and Photobiology, 82(1), 28-36.

Kikuchi, T., Mogi, M., Okabe, I., Okada, K., Goto, H., Sasaki, Y. Fujimura, T., Fukuda, M. & Mitani, A. (2015). Adjunctive Application of Antimicrobial Photodynamic Therapy in Nonsurgical Periodontal Treatment: A Review of Literature. International Journal of Molecular Sciences, 16(10), 24111-24126.

Kolbe, M.F., Ribeiro, F.V., Luchesi, V.H., Casarin, R.C., Sallum, E.A., Nociti Jr, F.H., Ambrosano, G.M.B., Cirano, F.R., Pimentel, S.P. & Casati, M.Z. (2014). Photodynamic Therapy During Supportive Periodontal Care: Clinical, Microbiologic, Immunoinflammatory, and Patient-Centered Performance in a Split-Mouth Randomized Clinical Trial. Journal of Periodontology, 85(8), 277-286.

Komerik, N., Nakanishi, H., MacRobert, A.J., Henderson, B., Speight, P. & Wilson, M. (2003). In vivo killing of Phorphiromonas gingivalis by toluidine blue-mediated photosensitization in an animal model. Antimicrobial Agents and Chemotherapy, 47(3), 932- 940.

Kyungwon, C., Lee, S.Y., Chang, B.S., Um, H.S. & Lee, J.K. (2015). The effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans attached to surface-modified titanium. Journal of Periodontal and Implant Science, 45(2), 38-45.

Lulic, M., Görög, I.L., Salvi, G.E., Ramseier, C.A., Mattheos, N. & Lang, N.P. (2009). One-year outcomes of repeated adjunctive photodynamic therapy during periodontal maintenance: a proof of principle randomized controlled clinical trial. Journal Clinic of Periodontology, 36(8), 661-666.

Machado, A.E.H. (2000). Terapia fotodinâmica: princípios, potencial de aplicação e perspectivas. Revista Química Nova, 23(2), 237-243.

Marques, E.C.P., Lopes, F.P., Nascimento, I.C., Morelli, J., Pereira, M.V., Meiken, V.M.M. & Pinheiro, S.L. (2019). Photobiomodulation and photodynamic therapy for the treatment of oral mucositis in patients with câncer. Photodiagnosis and Photodynamic Therapy, 29(1), 10-16.

Marotti, J., Aranha, A.C., Eduardo, C. P. & Ribeiro, M.S. (2009). Photodynamic therapy can be effective as a treatment for herpes simplex labialis. Photomedicine and Laser Surgery, 27(2), 357-63.

Melo, W., Avci, P., Oliveira, M.N., Gupta, A., Vecchio, D., Sadasivam, M., Chandran, R., Huang, Y.Y., Yin, R., Perussi, L.R., Tegos, G.P., Perussi, J.R., Dai, T. & Hamblin, M.R. (2013). Photodynamic inactivation of biofilm: taking a lightly colored approach to stubborn infection. Expert Review of Anti-infective Therapy, 11(7), 669-693.

Mima, E.G., Vergani, C.E., Machado, A.L., Massucato, E.M.S., Colombo, A.L., Bagnato, V.S. & Pavarina, A.C. (2012). Comparison of Photodynamic Therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial. Clinical Microbiology and Infection, 18(10), 380-388.

Nagata, J.Y., Hioka, N., Kimura, E., Batistela, V.R., Terada, R.S.S., Graciano, A.X., Baesso, M.L. & Hayacibara, M.R. (2012). Antibacterial photodynamic therapy for dental caries: evaluation of the photosensitizers used and light source properties. Photodiagnosis and Photodynamic Therapy, 9(2), 122-131.

Nishihara, T. & Koseki, T. (2004). Microbial etiology of periodontitis. Periodontology 2000, 36(1), 14-26.

Nuñez, S.C., Yoshimura, T.M., Ribeiro, M.S., Junqueira, H.C., Maciel, C., Coutinho-Neto, M.D. & Baptista, M.S. (2015). Urea enhances the photodynamic efficiency of methylene blue. The Journal of Photochemistry and Photobiology B, 150(1), 31-37.

O'connor, A.E., Gallagher, W.M. & Byrne, A.T. (2009). Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy. Photochemistry and Photobiology, 85(5), 1053-74.

Paschoal, M.A., Lin, M., Santos-Pinto, L. & Duarte, S. (2015). Photodynamic antimicrobial chemotherapy on Streptococcus mutans using curcumin and toluidine blue activated by a novel LED device. Lasers in Medical Science, 30(2), 885-890.

Pereira, A.S., Shitsuka, D.M., Parreira, F.J., Shitsuka, R. (2018). Metodologia da pesquisa científica. E-book.

Pfitzner, A., Sigusch, B.W., Albrecht, V. & Glockmann, E. (2004). Killing of periodontopathogenic bacteria by photodynamic therapy. Journal of Periodontology, 75(10), 1343-1349.

Polansky, R., Haas, M., Heschl, A. & Wimmer, G. (2009). Clinical effectiveness of photodynamic therapy in the treatment of periodontitis. Journal of Clinical Periodontology, 36(7), 575–580.

Puri, K. & Puri, N. (2013). Local drug delivery agents as adjuncts to endodontic and periodontal therapy. Journal of Medicine and Life, 6(4), 414-419.

Qin, Y.L., Luan, X.L., Bi, L.J., Sheng, Y.Q., Zhou, C.N. & Zhang, Z.G. (2008). Comparison of toluidine blue-mediated photodynamic therapy and conventional scaling treatment for periodontitis in rats. Journal of Periodontal Research, 43(2), 162-7.

Rhemrev, G.E., Timmerman, M.F., Veldkamp, I., Winkelhoff, A.J.V. & Velden, U.V. (2006). Immediate effect of instrumentation on the subgingival microflora in deep inflamed pockets under strict plaque control. Journal of Clinical Periodontology, 33(1), 42-48.

Roberts, G.J., Longhurst, P.P., Black, A.E., Lucas, V.S. (2000). Is there need for antibiotic prophylaxis for soem aspects of paediatric conservative dentistry? British Dental Journal, 188(2), 95-98.

Sarkar, S. & Wilson, M. (1993). Lethal photosensitization of bacteria in subgingival plaque from patients with chronic periodontitis. Journal of Periodontal Research, 28(3), 204-210.

Seguier, S., Souza, S.L.S, Sverzut, A.C.V., Simioni, A.R.S., Primo, F.L.P., Bodineau, A., Corrêa, V.M.A., Coulomb, B. & Tedesco, A.C. (2010). Impact of photodynamic therapy on inflammatory cells during human chronic periodontitis. Journal of Photochemistry and Photobiology B, 101(3), 348-354.

Selva, A.L., Negreiros, R.M., Bezerra, D.T., Rosa, E.P., Pavesi, V.C.S., Navarro, R.S., Bello-Silva, M.S., Ramalho, K.M., Aranha, A.C.C., Braz-Silva, P.H., Fernandes, K.P.S., Bussadori, S.K. & Horliana, A.C.R.T. (2020). Treatment of herpes labialis by photodynamic therapy: Study protocol clinical trial (SPIRIT compliant). Medicine, 99(12), 1-9.

Shibli, J.A., Martins, M.C., Theodoro, L.H., Lotufo, R.F.M., Garcia, V.G. & Marcantonio, E.J. (2003). Lethal photosensitization in microbiological treatment of ligature-induced peri-implantitis: a preliminary study in dogs. Journal of Oral Science, 45(1), 17-23.

Shrestha, A., Hamblin, M.R. & Kishen, A. (2014). Photoactivated rose bengal functionalized chitosan nanoparticles produce antibacterial/biofilm activity and stabilize dentin-collagen. Nanomedicine, 10(3), 491-501.

Soukos, N.S. & Goodson, J.M. (2011). Photodynamic therapy in the control of oral biofilms. Periodontology 2000, 55(1), 143-166.

Soukos, N.S., Ximenez-Fyvie, L.A., Hamblin, M.R., Socransky, S.S. & Hasan, T. (1998). Targeted antimicrobial photochemotherapy. Antimicrobial Agents and Chemotherapy, 42(10), 2595-2601.

Souza, R.C., Junqueira, J.C., Rossoni, R.D., Pereira, C.A., Munin, E. & Jorge, A.O.C. (2010). Comparison of the photodynamic fungicidal efficacy of methylene blue, toluidine blue, malachite green and low-power laser irradiation alone against Candida albicans. Lasers in Medical Science, 25(3), 385-389.

Sridharan, G. & Shankar, A.A. (2012). Toluidine blue: A review of its chemistry and clinical utility. Journal of Oral and Maxillofacial Pathology, 16(2), 251-255.

Street, C.N., Pedigo, L.A. & Loebel, N.G. (2010). Energy dose parameters affect antimicrobial photodynamic therapy-mediated eradication of periopathogenic biofilm and planktonic cultures. Photomedicine and Laser Surgery, 28(1), 61-66.

Szeimies, R.M. & Karrer, S. (2021). Photodynamic therapy-trends and new developments. Der Hautarzt, 72(1), 27-33.

Tabenski, L., Buchalla, W. & Maisch, T. (2014). Antimicrobial photodynamic therapy for inactivation of biofilms formed by oral key pathogens. Frontiers in Microbiology, 5(1), 1-17.

Takasaki, A.A., Aoki, A., Mizutani, K., Schwarz, F., Sculean, A., Wang, C-Y., Koshy, G., Romanos, G., Ishikawa, I. & Izumi, Y. (2009). Application antimicrobial photodynamic therapy in periodontal and peri-implant diseases. Periodontology 2000, 51(1), 109-140.

Tardivo, J.P., Giglio, A.D., Oliveira, C.S., Gabrielli, D.S., Junqueira, H.C., Tada, D.B., Severino, D., Turchiello, R.F. & Baptista, M.S. (2005). Methylene blue in photodynamic therapy: From basic mechanisms to clinical applications. Photodiagnosis and Photodynamic Therapy, 2(3), 175-191.

Tortora, G.J. (2010). Microbiologia: uma introdução. São Francisco: Pearson Benjamin Cummings.

Wainwright, M., Byrne, M.N. & Gattrell, M.A. (2006). Phenothiazinium-based photobactericidal materials. The Journal of Photochemistry and Photobiology B, 84(3), 227-230.

Wainwright, M. (2010). ‘Safe’ photoantimicrobials for skin and soft-tissue infections. International Journal of Antimicrobial Agents, 36(1), 14-18.

Watanabe, T., Fukuda, M., Mitani, A., Ting, C-C., Osawa, K., Nagahara, A., Satoh, S., Fujimura, T., Takahashi, S., Iwamura, Y., Murakami, T. & Noguchi, T. (2013). Nd:Yag laser irradiation of the tooth root surface inhibits demineralization and root surface softening caused by minocycline application. Photomedicine and Laser Surgery, 31(12), 571-557.

Wiebe, C.B. & Putnins, E.E. (2000). The periodontal disease classification system of the American academy of periodontology–an update. Journal of the Canadian Dental Association, 66(11), 594-597, 2000.

Wilson, B.C. & Patterson, M.S. (2008). The physics, biophysics and technology of photodynamic therapy. Physics in Medicine & Biology, 53(9), 61–109.

Yin, R., Dai, T., Avci, P., Jorge, A.E.S., Melo, W.C.M.A., Vecchio, D., Huang, Y-Y., Gupta, A. & Hamblin, M.R. (2013). Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond. Current Opinion in Pharmacology, 13(5), 731-762.

Zanin, I.C. & Brugnera, A. (2007). Terapia fotodinâmica no tratamento da doença periodontal. Perionews, 1(1), 79-85.

Zanin, I.C., Gonçalves, R.B., Junior, A.B., Hope, C.K. & Pratten, J. (2005). Susceptibility of Streptococcus mutans biofilms to photodynamic therapy: an in vitro study. Journal of Antimicrobial Chemotherapy, 56(2), 324-230.

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22/10/2021

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PEREIRA, I. de L. .; ANDRAUS, L. P. M. .; PEDRIALI, M. B. B. P. .; TIOSSI, P. P. C. .; ITO, F. A. N. . Terapia fotodinâmica como adjuvante ao tratamento periodontal: revisão de literatura. Research, Society and Development, [S. l.], v. 10, n. 13, p. e585101321534, 2021. DOI: 10.33448/rsd-v10i13.21534. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/21534. Acesso em: 26 nov. 2024.

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Ciências da Saúde