Plantas medicinais com atividade repelente de mosquitos: uma revisão sistemática

Autores

DOI:

https://doi.org/10.33448/rsd-v11i1.24142

Palavras-chave:

Plantas medicinais; Óleos essenciais; Mosquitos; Atividade repelente; Padronização; Aedes aegypti.

Resumo

Os repelentes são aliados importantes na tentativa de prevenir doenças transmitidas por picadas de mosquitos. As plantas têm sido fonte de diversos repelentes e inseticidas por apresentarem um grande reservatório de substâncias bioativas, além disso, seus produtos já foram testados e vêm ganhando espaço em pesquisas como alternativa de baixo custo e fácil acesso. Foi realizada revisão sistemática nas bases de dados Science Direct, Scielo, SciFinder, Springer, PubMed / Medline, Scopus e Web of Science, avaliadas por três revisores. Títulos, resumos e Artigos foram analisados na íntegra nos idiomas inglês, espanhol e português. Para a identificação dos artigos, foram utilizados os seguintes descritores do Medical Subject Headings (MeSH): “repelentes de insetos”, “óleos essenciais”, “extrato de plantas”, “atividade repelente”, mosquitos e plantas. A busca bibliográfica resultou em 2274 registros. Destes, 27 resumos foram considerados potencialmente relevantes e, ao final da seleção, 17 artigos foram incluídos na íntegra. Verificou-se que as plantas medicinais apresentaram atividade repelente contra várias espécies de mosquitos, porém devido à pouca padronização das metodologias utilizadas e dos produtos obtidos é necessário o desenvolvimento de métodos padronizados que garantam a qualidade e reprodutibilidade dos ensaios clínicos com plantas medicinais.

Referências

Abagli, A. Z., Alavo, T. B., Avlessi, F., & Moudachirou, M. (2012). Potential of the bush mint, Hyptis suaveolens essential oil for personal protection against mosquito biting. Journal of the American Mosquito Control Association, 28(1), 15-19. https://doi.org/10.2987/11-6181.1

Adams, R. P. (2007). Identification of essential oil components by gas chromatography/mass spectrometry (Vol. 456). Carol Stream, IL: Allured publishing corporation.

Ali, M. S., Ravikumar, S., & Beula, J. M. (2012). Bioactivity of seagrass against the dengue fever mosquito Aedes aegypti larvae. Asian Pacific journal of tropical biomedicine, 2(7), 570-573. https://doi.org/10.1016/S2221-1691(12)60099-9

Ao, H., Wang, J., Chen, L., Li, S., & Dai, C. (2019). Comparison of volatile oil between the fruits of Amomum villosum Lour. and Amomum villosum Lour. var. xanthioides TL Wu et Senjen based on GC-MS and chemometric techniques. Molecules, 24(9), 1663. doi:10.3390/molecules24091663

Bayala, B., Nadembega, C., Guenné, S., Buñay, J., Zohoncon, M., Djigma, W., ... & Simpore, J. (2020). Chemical Composition, Antioxidant and Cytotoxic Activities of Hyptis suaveolens (L.) Poit. Essential Oil on Prostate and Cervical Cancers Cells. Pakistan Journal of Biological Sciences: PJBS, 23(9), 1184-1192. 10.3923/pjbs.2020.1184.1192.

Booth, A., Clarke, M., Dooley, G., Ghersi, D., Moher, D., Petticrew, M., & Stewart, L. (2012). The nuts and bolts of PROSPERO: an international prospective register of systematic reviews. Systematic reviews, 1(1), 1-9. 10.1186/2046-4053-1-2.

Cappiello, A., Tirillini, B., Famiglini, G., Trufelli, H., Termopoli, V., & Flender, C. (2012). Determination of Natural Pyrethrins by Liquid Chromatography‐Electron Ionisation‐Mass Spectrometry. Phytochemical Analysis, 23(3), 191-196. https://doi.org/10.1002/pca.1342

Carroll, S. P., & Loye, J. (2006). PMD, a registered botanical mosquito repellent with deet-like efficacy. Journal of the American Mosquito Control Association, 22(3), 507-514. https://doi.org/10.2987/8756-971X(2006)22[507:PARBMR]2.0.CO;2

Choochote, W., Chaithong, U., Kamsuk, K., Jitpakdi, A., Tippawangkosol, P., Tuetun, B. & Pitasawat, B. (2007). Repellent activity of selected essential oils against Aedes aegypti. Fitoterapia, 78(5), 359-364. https://doi.org/10.1016/j.fitote.2007.02.006.

da Silva, L. C., de Souza Perinotto, W. M., Sá, F. A., de Souza, M. A. A., Bitencourt, R. D. O. B., Sanavria, A., ... & da Costa Angelo, I. (2020). In vitro acaricidal activity of Cymbopogon citratus, Cymbopogon nardus and Mentha arvensis against Rhipicephalus microplus (Acari: Ixodidae). Experimental Parasitology, 216, 107937. 10.1016/j.exppara.2020.107937.

Dalawai, D., Aware, C., Jadhav, J. P., & Murthy, H. N. (2019). RP-HPLC analysis of diterpene lactones in leaves and stem of different species of Andrographis. Natural Product Research, 1-4. 10.1080/14786419.2019.1662004

Deletre, E., Martin, T., Duménil, C., & Chandre, F. (2019). Insecticide resistance modifies mosquito response to DEET and natural repellents. Parasites & vectors, 12(1), 1-10. https://doi.org/10.1186/s13071-019-3343-9

Edwin, E. S., Vasantha-Srinivasan, P., Senthil-Nathan, S., Thanigaivel, A., Ponsankar, A., Pradeepa, V., ... & Al-Dhabi, N. A. (2016). Anti-dengue efficacy of bioactive andrographolide from Andrographis paniculata (Lamiales: Acanthaceae) against the primary dengue vector Aedes aegypti (Diptera: Culicidae). Acta tropica, 163, 167-178. 10.1016/j.actatropica.2016.07.009

Elango, G., Rahuman, A. A., Zahir, A. A., Kamaraj, C., Bagavan, A., Rajakumar, G. & Marimuthu, S. (2010). Evaluation of repellent properties of botanical extracts against Culex tritaeniorhynchus Giles (Diptera: Culicidae). Parasitology research, 107(3), 577-584. https://doi.org/10.1007/s00436-010-1897-8

Folashade, O., Omoregie, H., & Ochogu, P. (2012). Standardization of herbal medicines-A review. International Journal of Biodiversity and Conservation, 4(3), 101-112. https://doi.org/10.5897/IJBC11.163

Gagnier, J. J., Boon, H., Rochon, P., Moher, D., Barnes, J., & Bombardier, C. (2006). Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement. Annals of internal medicine, 144(5), 364-367. 10.7326/0003-4819-144-5-200603070-00013.

Geetha, R. V., & Roy, A. (2014). Essential oil repellents-a short review. International Journal of Drug Development and Research, 6(2), 20-27.

Ghosh, A., Chowdhury, N., & Chandra, G. (2012). Plant extracts as potential mosquito larvicides. The Indian journal of medical research, 135(5), 581-598.

Govere, J., Durrheim, D. N., Baker, L., Hunt, R., & Coetzee, M. (2000). Efficacy of three insect repellents against the malaria vector Anopheles arabiensis. Medical and Veterinary Entomology, 14(4), 441-444. https://doi.org/10.1046/j.1365-2915.2000.00261.x

Guenther, E. (1972). The production of essential oils. The essential oils, 1, 87-226.

Hadis, M., Lulu, M., Mekonnen, Y., & Asfaw, T. (2003). Field trials on the repellent activity of four plant products against mainly Mansonia population in western Ethiopia. Phytotherapy research, 17(3), 202-205. https://doi.org/10.1002/ptr.1051

Han, L., Wang, R., Zhang, X., Yu, X., Zhou, L., Song, T., ... & Bai, C. (2019). Advances in processing and quality control of traditional chinese medicine Coptidis rhizoma (Huanglian): A Review. Journal of AOAC International, 102(3), 699-707. https://doi.org/10.5740/jaoacint.18-0303

Hill, N., Lenglet, A., Arnez, A. M., & Carneiro, I. (2007). Plant based insect repellent and insecticide treated bed nets to protect against malaria in areas of early evening biting vectors: double blind randomised placebo controlled clinical trial in the Bolivian Amazon. BMJ, 335(7628), 1023. https://doi.org/10.1136/bmj.39356.574641.55

Huang, K. (2020) GC - MS Analysis of Volatile Components in Curcuma Zedoary [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 01, 69-75. 10.13424/j.cnki.jsctcm.2020.01.018.

Itthipanichpong, C., Ruangrungsi, N., & Pattanaautsahakit, C. (2002). Chemical compositions and pharmacological effects of essential oil from the fruit of Zanthoxylum limonella. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 85, S344-54.

Jaradat, N., Adwan, L., K’aibni, S., Zaid, A. N., Shtaya, M. J., Shraim, N., & Assali, M. (2017). Variability of chemical compositions and antimicrobial and antioxidant activities of Ruta chalepensis leaf essential oils from three Palestinian regions. BioMed Research International, 2017. 10.1155/2017/2672689.

Kang, S. H., Kim, M. K., Seo, D. K., Noh, D. J., Yang, J. O., Yoon, C., & Kim, G. H. (2009). Comparative repellency of essential oils against Culex pipiens pallens (Diptera: Culicidae). Journal of the Korean Society for Applied Biological Chemistry, 52(4), 353-359. https://doi.org/10.3839/jksabc.2009.063

Karunamoorthi, K., Ilango, K., & Murugan, K. (2010). Laboratory evaluation of traditionally used plant-based insect repellent against the malaria vector Anopheles arabiensis Patton (Diptera: Culicidae). Parasitology research, 106(5), 1217-1223. https://doi.org/10.1007/s00436-010-1797-y

Keziah, E. A., Nukenine, E. N., Danga, S. P. Y., Younoussa, L., & Esimone, C. O. (2015). Creams formulated with Ocimum gratissimum L. and Lantana camara L. crude extracts and fractions as mosquito repellents against Aedes aegypti L. (Diptera: Culicidae). Journal of Insect Science, 15(1). https://doi.org/10.1093/jisesa/iev025

Laribi, B., Kouki, K., Mougou, A., & Marzouk, B. (2010). Fatty acid and essential oil composition of three Tunisian caraway (Carum carvi L.) seed ecotypes. Journal of the Science of Food and Agriculture, 90(3), 391-396. https://doi.org/10.1002/jsfa.3827

Li, Y., Kong, D., Huang, R., Liang, H., Xu, C., & Wu, H. (2013). Variations in essential oil yields and compositions of Cinnamomum cassia leaves at different developmental stages. Industrial Crops and Products, 47, 92–101. 10.1016/j.indcrop.2013.02.031

Lima, A. S., Milhomem, M. N., Monteiro, O. S., Arruda, A. C. P., de Castro, J. A. M., Fernandes, Y. M. L., ... & Costa-Junior, L. M. (2018). Seasonal analysis and acaricidal activity of the thymol-type essential oil of Ocimum gratissimum and its major constituents against Rhipicephalus microplus (Acari: Ixodidae). Parasitology Research, 117(1), 59-65. https://doi.org/10.1007/s00436-017-5662-0

Liu, C., Guo, D. A., & Liu, L. (2018). Quality transitivity and traceability system of herbal medicine products based on quality markers. Phytomedicine, 44, 247-257. https://doi.org/10.1016/j.phymed.2018.03.006

Liu, L., Song, G., & Hu, Y. (2007). GC–MS Analysis of the Essential Oils of Piper nigrum L. and Piper longum L. Chromatographia, 66(9), 785-790. 10.1365/s10337-007-0408-2

Liu, X. C., Liang, Y., Shi, W. P., Liu, Q. Z., Zhou, L., & Liu, Z. L. (2014). Repellent and insecticidal effects of the essential oil of Kaempferia galanga rhizomes to Liposcelis bostrychophila (Psocoptera: Liposcelidae). Journal of Economic Entomology, 107(4), 1706-1712. 10.1603/ec13491.

Maia, M. F., & Moore, S. J. (2011). Plant-based insect repellents: a review of their efficacy, development and testing. Malaria journal, 10(1), 1-15. https://doi.org/10.1186/1475-2875-10-S1-S11

Manh, H. D., Hue, D. T., Hieu, N. T. T., Tuyen, D. T. T., & Tuyet, O. T. (2020). The Mosquito larvicidal activity of essential oils from Cymbopogon and Eucalyptus Species in Vietnam. Insects, 11(2), 128. 10.3390/insects11020128.

Marques, M. M., Morais, S. M., Vieira, Í. G., Vieira, M. G., Silva, A. R. A., De Almeida, R. R., & Guedes, M. I. F. (2011). Larvicidal activity of Tagetes erecta against Aedes aegypti. Journal of the American Mosquito Control Association, 27(2), 156-158. 10.2987/10-6056.1.

Marrelli, M., Amodeo, V., Viscardi, F., De Luca, M., Statti, G., & Conforti, F. (2020). Essential Oils of Foeniculum vulgare subsp. piperitum and Their in Vitro Anti‐Arthritic Potential. Chemistry & Biodiversity, 17(11), e2000388. https://doi.org/10.1002/cbdv.202000388

McHugh, M. L. (2012). Interrater reliability: the kappa statistic. Biochemia medica, 22(3), 276-282.

Misni, N., Sulaiman, S., Othman, H., & Omar, B. (2009). Repellency of essential oil of Piper aduncum against Aedes albopictus in the laboratory. Journal of the American Mosquito Control Association, 25(4), 442-447. https://doi.org/10.2987/09-0006.1

Mohamed, A. A., Behiry, S. I., Younes, H. A., Ashmawy, N. A., Salem, M. Z. M., Márquez-Molina, O., & Barbabosa-Pilego, A. (2019). Antibacterial activity of three essential oils and some monoterpenes against Ralstonia solanacearum phylotype II isolated from potato. Microbial Pathogenesis, 135, 103604. https://doi.org/10.1016/j.micpath.2019.103604

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G. (2009). The PRISMA Group Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLOS Medicine, 6(7), e1000097. https://doi.org/10.1371/journal.pmed.1000097

Monzote, L., Scull, R., Cos, P., & Setzer, W. N. (2017). Essential oil from Piper aduncum: Chemical analysis, antimicrobial assessment, and literature review. Medicines, 4(3), 49. 10.3390/medicines4030049.

Moon, H. I., Cho, S. B., & Kim, S. K. (2011). Retracted: Composition and immunotoxicity activity of essential oils from leaves of Zingiber officinale Roscoe against Aedes aegypti L. Immunopharmacology and immunotoxicology, 33(1), 201-204. 10.3109/08923973.2010.495393.

Moore, S. J., Darling, S. T., Sihuincha, M., Padilla, N., & Devine, G. J. (2007). A low-cost repellent for malaria vectors in the Americas: results of two field trials in Guatemala and Peru. Malaria Journal, 6(1), 1-6. https://doi.org/10.1186/1475-2875-6-101

Muráriková, A., Ťažký, A., Neugebauerová, J., Planková, A., Jampílek, J., Mučaji, P., & Mikuš, P. (2017). Characterization of essential oil composition in different basil species and pot cultures by a GC-MS method. Molecules, 22(7), 1221. https://doi.org/10.3390/molecules22071221

Murugan, K., Kumar, P. M., Kovendan, K., Amerasan, D., Subrmaniam, J., & Hwang, J. S. (2012). Larvicidal, pupicidal, repellent and adulticidal activity of Citrus sinensis orange peel extract against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae). Parasitology research, 111(4), 1757-1769. https://doi.org/10.1007/s00436-012-3021-8

Naseem, S., Malik, M. F., & Munir, T. (2016). Mosquito management: A review. Journal of Entomology and Zoology Studies, 4(5), 73-79.

Nea, F., Kambiré, D. A., Genva, M., Tanoh, E. A., Wognin, E. L., Martin, H., ... & Fauconnier, M. L. (2020). Composition, seasonal variation, and biological activities of Lantana camara essential oils from Côte d’Ivoire. Molecules, 25(10), 2400. https://doi.org/10.3390/molecules25102400

Nerio, L. S., Olivero-Verbel, J., & Stashenko, E. (2010). Repellent activity of essential oils: a review. Bioresource technology, 101(1), 372-378. https://doi.org/10.1016/j.biortech.2009.07.048

Ogunbinu, A. O., Flamini, G., Cioni, P. L., Ogunwande, I. A., & Okeniyi, S. O. (2009). Essential oil constituents of Eclipta prostrata (L.) L. and Vernonia amygdalina Delile. Natural Product Communications, 4(3), 421-424. https://doi.org/10.1177/1934578X0900400321

Pant, P., Sut, S., Castagliuolo, I., Gandin, V., Maggi, F., Gyawali, R., & Dall'Acqua, S. (2019). Sesquiterpene rich essential oil from nepalese bael tree (Aegle marmelos (l.) correa) as potential antiproliferative agent. Fitoterapia, 138, 104266. https://doi.org/10.1016/j.fitote.2019.104266

Pohlit, A. M., Lopes, N. P., Gama, R. A., Tadei, W. P., & Andrade Neto, V. F. D. (2011). Patent literature on mosquito repellent inventions which contain plant essential oils-a review. Volume 77, Número 6, Pags. 598-617. http://dx.doi.org/10.1055/s-0030-1270723

Qiao, Y., Xie, B. J., Zhang, Y., Zhang, Y., Fan, G., Yao, X. L., & Pan, S. Y. (2008). Characterization of aroma active compounds in fruit juice and peel oil of Jinchen sweet orange fruit (Citrus sinensis (L.) Osbeck) by GC-MS and GC-O. Molecules, 13(6), 1333-1344. https://doi.org/10.3390/molecules13061333

Qin, X. W., Hao, C. Y., He, S. Z., Wu, G., Tan, L. H., Xu, F., & Hu, R. S. (2014). Volatile organic compound emissions from different stages of Cananga odorata flower development. Molecules, 19(7), 8965-8980. doi:10.3390/molecules19078965

Radunz, M., Martins da Trindade, M. L., Camargo, T. M., Radunz, A. L., Borges, C. D., Gandra, E. A., & Helbig, E. (2019). Antimicrobial and antioxidant activity of unencapsulated and encapsulated clove (Syzygium aromaticum, L.) essential oil. Food Chemistry, 276, 180-186. 10.1016/j.foodchem.2018.09.173.

Rajan, T. V., Hein, M., Porte, P., & Wikel, S. (2005). A double‐blinded, placebo‐controlled trial of garlic as a mosquito repellant: a preliminary study. Medical and veterinary entomology, 19(1), 84-89.https://doi.org/10.1111/j.0269-283X.2005.00544.x

Raveau, R., Fontaine, J., & Lounès-Hadj Sahraoui, A. (2020). Essential oils as potential alternative biocontrol products against plant pathogens and weeds: A review. Foods, 9(3), 365. https://doi.org/10.3390/foods9030365

Reiter, P. (2001). Climate change and mosquito-borne disease. Environmental health perspectives, 109(suppl 1), 141-161. https://doi.org/10.1289/ehp.01109s1141

Rueda, L.M (2008). Global diversity of mosquitoes (Insecta: Diptera: Culicidae) in freshwater. Hydrobiology, 595, 477–487. https://doi.org/10.1007/s10750-007-9037-x

Sajo, M. V., Song, S. B., Bajgai, J., Kim, Y. J., Kim, P. S., Ahn, D. W., ... & Lee, K. J. (2015). Applicability of citronella oil ('Cymbopogon winteratus') for the prevention of mosquito-borne diseases in the rural area of Tikapur, far-western Nepal. Rural and remote health, 15(4), 121.

Sakpal, T. (2010). Sample size estimation in clinical trial. Perspectives in clinical research, 1(2), 67-67.

Sangwan, N. S., Farooqi, A. H. A., Shabih, F., & Sangwan, R. S. (2001). Regulation of essential oil production in plants. Plant growth regulation, 34(1), 3-21. https://doi.org/10.1023/A:1013386921596

Santamaría, E., Cabrera, O. L., Zipa, Y., & Pardo, R. H. (2012). Eficacia en campo de un repelente a base de para-mentano-3, 8-diol y aceite de limonaria contra Culicoides pachymerus (Diptera: Ceratopogonidae) en Colombia. Biomédica, 32(3), 457-460. http://dx.doi.org/10.7705/biomedica.v32i3.738.

Satyal, P., Craft, J. D., Dosoky, N. S., & Setzer, W. N. (2017). The chemical compositions of the volatile oils of garlic (Allium sativum) and wild garlic (Allium vineale). Foods, 6(8), 63. https://doi.org/10.3390/foods6080063

Shapiro, R. (2012). Prevention of vector transmitted diseases with clove oil insect repellent. Journal of pediatric nursing, 27(4), 346-349. https://doi.org/10.1016/j.pedn.2011.03.011

Silva, C. T. S., Wanderley-Teixeira, V., Cunha, F. M., Oliveira, J. V., Dutra, K. A., Navarro, D. F., & Teixeira, A. A. C. (2018). Effects of citronella oil (Cymbopogon winterianus Jowitt ex Bor) on Spodoptera frugiperda (JE Smith) midgut and fat body. Biotechnic & Histochemistry, 93(1), 36-48. 10.1080/10520295.2017.1379612.

Snuossi, M., Trabelsi, N., Ben Taleb, S., Dehmeni, A., Flamini, G., & De Feo, V. (2016). Laurus nobilis, Zingiber officinale and Anethum graveolens essential oils: composition, antioxidant and antibacterial activities against bacteria isolated from fish and shellfish. Molecules, 21(10), 1414. doi:10.3390/molecules21101414

Sollepura Boregowda, R., Murali, N., C Udayashankar, A., R Niranjana, S., S Lund, O., & S Prakash, H. (2019). Antifungal Activity of Eclipta alba Metabolites against Sorghum Pathogens. Plants (Basel, Switzerland), 8(3), 72. https://doi.org/10.3390/plants8030072

Soonwera, M., & Phasomkusolsil, S. (2015). Efficacy of Thai herbal essential oils as green repellent against mosquito vectors. Acta tropica, 142, 127-130. https://doi.org/10.1016/j.actatropica.2014.11.010

Sritabutra, D., & Soonwera, M. (2013). Repellent activity of herbal essential oils against Aedes aegypti (Linn.) and Culex quinquefasciatus (Say.). Asian Pacific Journal of Tropical Disease, 3(4), 271–276. https://doi.org/10.1016/S2222-1808(13)60069-9

Stanczyk, N. M., Brookfield, J. F., Ignell, R., Logan, J. G., & Field, L. M. (2010). Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function. Proceedings of the National Academy of Sciences, 107(19), 8575-8580.

Tao, N., Jia, L., & Zhou, H. (2014). Anti-fungal activity of Citrus reticulata Blanco essential oil against Penicillium italicum and Penicillium digitatum. Food chemistry, 153, 265-271. https://doi.org/10.1016/j.foodchem.2013.12.070

Thavamani, B. S., Mathew, M., & Palaniswamy, D. S. (2014). Anticancer activity of Cocculus hirsutus against Dalton’s lymphoma ascites (DLA) cells in mice. Pharmaceutical biology, 52(7), 867-872. https://doi.org/10.3109/13880209.2013.871642.

Trongtokit, Y., Rongsriyam, Y., Komalamisra, N., & Apiwathnasorn, C. (2005). Comparative repellency of 38 essential oils against mosquito bites. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 19(4), 303-309. https://doi.org/10.1002/ptr.1637

Umar, M. I., Asmawi, M. Z., Sadikun, A., Abdul Majid, A. M. S., Atangwho, I. J., Khadeer Ahamed, M. B., ... & Ahmad, A. (2014). Multi-constituent synergism is responsible for anti-inflammatory effect of Azadirachta indica leaf extract. Pharmaceutical Biology, 52(11), 1411-1422. https://doi.org/10.3109/13880209.2014.895017

US EPA. 1999. “Citronella (Oil of Citronella) (021901) Fact Sheet.” 21901. RED Facts. Washington, DC: US EPA Office of Pesticides and Toxic Substances. https://www3.epa.gov/pesticides/chem_search/reg_actions/registration/fs_PC021901_01-Nov-99.pdf.

Varun, T., Ruchi, Y., Kumar, S. A., Vivek, T., Shweta, Y., Veer, V., & Devanathan, S. (2013). Larvicidal activity of leaf extract of some weeds against malaria vector Anopheles stephensi. International journal of environmental research and public health, 1, 35-39.

Wilke, A. B. B., & Marrelli, M. T. (2015). Paratransgenesis: a promising new strategy for mosquito vector control. Parasites & Vectors, 8(1), 342, 1-9. https://doi.org/10.1186/s13071-015-0959-2

World Health Organization. (2009). Guidelines for efficacy testing of mosquito repellents for human skin (No. WHO/HTM/NTD/WHOPES/2009.4). World Health Organization.

World Health Organization. (2016). Cumulative Zika suspected and confirmed cases reported by countries and territories in the Americas, 2015-2016.

World Health Organization. (2017). Global vector control response 2017-2030.

World Health Organization. (2020). Vector-borne diseases. https://www.who.int/news-room/fact-sheets/detail/vector-borne-diseases.

Downloads

Publicado

01/01/2022

Como Citar

SANTOS, A. R. dos; SANTOS, A. M.; ALMEIDA, F. H. O. de; MEDEIROS, V. F. A. de; MATOS, S. S. .; CARVALHO, T. F. de; SOUZA , C. A. S. .; LIMA, T. C.; SILVA, F. A. da. Plantas medicinais com atividade repelente de mosquitos: uma revisão sistemática . Research, Society and Development, [S. l.], v. 11, n. 1, p. e2611124142, 2022. DOI: 10.33448/rsd-v11i1.24142. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/24142. Acesso em: 23 nov. 2024.

Edição

Seção

Ciências da Saúde