Relação entre sinais e sintomas neuropsiquiátricos e infecção por SARS-CoV-2: uma revisão integrativa
DOI:
https://doi.org/10.33448/rsd-v11i2.25460Palavras-chave:
Coronavirus; COVID-19; Psiquiatria; Sistema Nervoso; Vírus da SARS.Resumo
Introdução: Muitos vírus, incluindo CoVs, podem afetar o sistema nervoso, causando sinais e sintomas neuropsiquiátricos. Por se tratar de uma doença desconhecida e amplamente disseminada, existem poucos estudos que tratam dos efeitos do SARS-CoV-2 no sistema nervoso. Objetivo: Descrever a relação entre os sinais e sintomas neuropsiquiátricos e a infecção pelo vírus da SARS-CoV-2. Método: Revisão integrativa realizada no Portal Pubmed, Biblioteca Virtual da Saúde, Cochrane e no buscador acadêmico Science Direct. Os trabalhos foram analisados de forma qualitativa, com a descrição narrativa dividida em quatro categorias temáticas. Resultados: Foram encontrados 1024 trabalhos e selecionados 48 estudos para compor essa revisão integrativa. Existe uma relação fisiopatológica da infecção por SARS-CoV-2 e o acometimento do Sistema Nervoso Central e Sistema Nervoso Periférico por meio de diferentes vias e mecanismos. Conclusão: A monitorização dos pacientes durante e após a COVID-19 pode minimizar as sequelas de cunho neuropsiquiátricos decorrentes dessa doença, principalmente nos pacientes idosos com comorbidades.
Referências
Abboud, H., Abboud, F. Z., Kharbouch, H., Arkha, Y., El Abbadi, N., & El Ouahabi, A. (2020). COVID-19 and SARS-Cov-2 Infection: Pathophysiology and Clinical Effects on the Nervous System. World neurosurgery, 140, 49-53. https://doi.org/10.1016/j.wneu.2020.05.193
Afshar, H., Yassin, Z., Kalantari, S., Aloosh, O., Lotfi, T., Moghaddasi, M., Sadeghipour, A., & Emamikhah, M. (2020). Evolution and resolution of brain involvement associated with SARS- CoV2 infection: A close Clinical - Paraclinical follow up study of a case. Multiple sclerosis and related disorders, 43, 102216. https://doi.org/10.1016/j.msard.2020.102216
Agyeman, A. A., Chin, K. L., Landersdorfer, C. B., Liew, D., & Ofori-Asenso, R. (2020). Smell and taste dysfunction in patients with COVID-19: a Systematic Review and Meta-analysis. Mayo Clinic proceedings, 95(8), 1621-1631. https://doi.org/10.1016/j.mayocp.2020.05.030
Avula, A., Nalleballe, K., Narula, N., Sapozhnikov, S., Dandu, V., Toom, S., Glaser, A., & Elsayegh, D. (2020). COVID-19 presenting as stroke. Brain, behavior, and immunity, 87, 115-119. https://doi.org/10.1016/j.bbi.2020.04.077
Baig, A. M., & Sanders, E. C. (2020). Potential neuroinvasive pathways of SARS-CoV-2: Deciphering the spectrum of neurological deficit seen in coronavirus disease-2019 (COVID-19). Journal of medical virology, 92(10), 1845-1857. https://doi.org/10.1002/jmv.26105
Baig, A. M., Khaleeq, A., Ali, U., & Syeda, H. (2020). Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS chemical neuroscience, 11(7), 995-998. https://doi.org/10.1021/acschemneuro.0c00122
Baller, E. B., Hogan, C. S., Fusunyan, M. A., Ivkovic, A., Luccarelli, J. W., Madva, E., ... & Smith, F. A. (2020). Neurocovid: Pharmacological recommendations for delirium associated with COVID-19. Psychosomatics, 61(6), 585-596. https://doi.org/10.1016/j.psym.2020.05.013
Barrios-López, J. M., Rego-García, I., Muñoz Martínez, C., Romero-Fábrega, J. C., Rivero Rodríguez, M., Ruiz Giménez, J. A., Escamilla-Sevilla, F., Mínguez-Castellanos, A., & Fernández Pérez, M. D. (2020). Ischaemic stroke and SARS-CoV-2 infection: A causal or incidental association? Neurologia (Barcelona, Spain), 35(5), 295-302. https://doi.org/10.1016/j.nrl.2020.05.002
Beach, S. R., Praschan, N. C., Hogan, C., Dotson, S., Merideth, F., Kontos, N., Fricchione, G. L., & Smith, F. A. (2020). Delirium in COVID-19: A case series and exploration of potential mechanisms for central nervous system involvement. General hospital psychiatry, 65, 47-53. https://doi.org/10.1016/j.genhosppsych.2020.05.008
Bigaut, K., Mallaret, M., Baloglu, S., Nemoz, B., Morand, P., Baicry, F., Godon, A., Voulleminot, P., Kremer, L., Chanson, J. B., & de Seze, J. (2020). Guillain-Barré syndrome related to SARS-CoV-2 infection. Neurology(R) neuroimmunology & neuroinflammation, 7(5), e785. https://doi.org/10.1212/NXI.0000000000000785
Brito, W. G. F., Silva, J. P. D. O. (2020). Neuropathological impacts of COVID-19. Brazilian Journal of Health Review, 3(3), 4227-4235. https://doi.org/10.34119/bjhrv3n3-026
Brun, G., Hak, J. F., Coze, S., Kaphan, E., Carvelli, J., Girard, N., & Stellmann, J. P. (2020). COVID-19-White matter and globus pallidum lesions: Demyelination or small-vessel vasculitis? Neurology(R) neuroimmunology & neuroinflammation, 7(4), e777. https://doi.org/10.1212/NXI.0000000000000777
Caamaño, D. S. J., & Beato, R. A. (2020). Facial diplegia, a possible atypical variant of Guillain-Barré Syndrome as a rare neurological complication of SARS-CoV-2. Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia, 77, 230-232. https://doi.org/10.1016/j.jocn.2020.05.016
Carod-Artal F. J. (2020). Neurological complications of coronavirus and COVID-19. Complicaciones neurológicas por coronavirus y COVID-19. Revista de neurologia, 70(9), 311-322. https://doi.org/10.33588/rn.7009.2020179
Das, G., Mukherjee, N., & Ghosh, S. (2020). Neurological Insights of COVID-19 Pandemic. ACS chemical neuroscience, 11(9), 1206-1209. https://doi.org/10.1021/acschemneuro.0c00201
Dogan, L., Kaya, D., Sarikaya, T., Zengin, R., Dincer, A., Akinci, I. O., & Afsar, N. (2020). Plasmapheresis treatment in COVID-19-related autoimmune meningoencephalitis: Case series. Brain, behavior, and immunity, 87, 155-158. https://doi.org/10.1016/j.bbi.2020.05.022
Faried, A., Dian, S., Halim, D., Hermanto, Y., Pratama, D., & Arifin, M. Z. (2020). The neurological significance of COVID-19: Lesson learn from the pandemic. Interdisciplinary neurosurgery: Advanced techniques and case management, 22, 100809. https://doi.org/10.1016/j.inat.2020.100809
Farzi, M. A., Ayromlou, H., Jahanbakhsh, N., Bavil, P. H., Janzadeh, A., & Shayan, F. K. (2020). Guillain-Barré syndrome in a patient infected with SARS-CoV-2, a case report. Journal of neuroimmunology, 346, 577294. https://doi.org/10.1016/j.jneuroim.2020.577294
Felice, F. G., Tovar-Moll, F., Moll, J., Munoz, D. P., & Ferreira, S. T. (2020). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System. Trends in neurosciences, 43(6), 355-357. https://doi.org/10.1016/j.tins.2020.04.004
Freni, F., Meduri, A., Gazia, F., Nicastro, V., Galletti, C., Aragona, P., Galletti, C., Galletti, B., & Galletti, F. (2020). Symptomatology in head and neck district in coronavirus disease (COVID-19): A possible neuroinvasive action of SARS-CoV-2. American journal of otolaryngology, 41(5), 102612. https://doi.org/10.1016/j.amjoto.2020.102612
Helms, J., Kremer, S., Merdji, H., Clere-Jehl, R., Schenck, M., Kummerlen, C., Collange, O., Boulay, C., Fafi-Kremer, S., Ohana, M., Anheim, M., & Meziani, F. (2020). Neurologic Features in Severe SARS-CoV-2 Infection. The New England journal of medicine, 382(23), 2268-2270. https://doi.org/10.1056/NEJMc2008597
Hosseini, A. A., Shetty, A. K., Sprigg, N., Auer, D. P., & Constantinescu, C. S. (2020). Delirium as a presenting feature in COVID-19: Neuroinvasive infection or autoimmune encephalopathy? Brain, behavior, and immunity, 88, 68-70. https://doi.org/10.1016/j.bbi.2020.06.012
Kandasamy M. (2020). Perspectives for the use of therapeutic Botulinum toxin as a multifaceted candidate drug to attenuate COVID-19. Medicine in drug discovery, 6, 100042. https://doi.org/10.1016/j.medidd.2020.100042
Kaya, Y., Kara, S., Akinci, C., & Kocaman, A. S. (2020). Transient cortical blindness in COVID-19 pneumonia; a PRES-like syndrome: Case report. Journal of the neurological sciences, 413, 116858. https://doi.org/10.1016/j.jns.2020.116858
Kemp, H. I., Corner, E., & Colvin, L. A. (2020). Chronic pain after COVID-19: implications for rehabilitation. British journal of anaesthesia, 125(4), 436-440. https://doi.org/10.1016/j.bja.2020.05.021
Kilic, O., Kalcioglu, M. T., Cag, Y., Tuysuz, O., Pektas, E., Caskurlu, H., & Cetın, F. (2020). Could sudden sensorineural hearing loss be the sole manifestation of COVID-19? An investigation into SARS-COV-2 in the etiology of sudden sensorineural hearing loss. International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases, 97, 208-211. https://doi.org/10.1016/j.ijid.2020.06.023
Koralnik, I. J., & Tyler, K. L. (2020). COVID-19: A Global Threat to the Nervous System. Annals of neurology, 88(1), 1-11. https://doi.org/10.1002/ana.25807
Kosugi, E. M., Lavinsky, J., Romano, F. R., Fornazieri, M. A., Luz-Matsumoto, G. R., Lessa, M. M., Piltcher, O. B., & Sant'Anna, G. D. (2020). Incomplete and late recovery of sudden olfactory dysfunction in COVID-19. Brazilian journal of otorhinolaryngology, 86(4), 490-496. https://doi.org/10.1016/j.bjorl.2020.05.001
Lee, J. M., & Lee, S. J. (2020). Olfactory and Gustatory Dysfunction in a COVID-19 Patient with Ankylosing Spondylitis Treated with Etanercept: Case Report. Journal of Korean medical science, 35(21), e201. https://doi.org/10.3346/jkms.2020.35.e201
Li, H., Xue, Q., & Xu, X. (2020). Involvement of the Nervous System in SARS-CoV-2 Infection. Neurotoxicity research, 38(1), 1-7. https://doi.org/10.1007/s12640-020-00219-8
Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., Miao, X., Li, Y., & Hu, B. (2020). Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA neurology, 77(6), 683-690. https://doi.org/10.1001/jamaneurol.2020.1127
Matías-Guiu, J., Gomez-Pinedo, U., Montero-Escribano, P., Gomez-Iglesias, P., Porta-Etessam, J., & Matias-Guiu, J. A. (2020). Should we expect neurological symptoms in the SARS-CoV-2 epidemic? Neurologia (Barcelona, Spain), 35(3), 170-175. https://doi.org/10.1016/j.nrl.2020.03.001
Melley, L. E., Bress, E., & Polan, E. (2020). Hypogeusia as the initial presenting symptom of COVID-19. BMJ case reports, 13(5), e236080. https://doi.org/10.1136/bcr-2020-236080
Msigwa, S. S., Wang, Y., Li, Y., & Cheng, X. (2020). The neurological insights of the emerging coronaviruses. Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia, 78, 1-7. https://doi.org/10.1016/j.jocn.2020.06.006
Panariello, A., Bassetti, R., Radice, A., Rossotti, R., Puoti, M., Corradin, M., Moreno, M., & Percudani, M. (2020). Anti-NMDA receptor encephalitis in a psychiatric Covid-19 patient: A case report. Brain, behavior, and immunity, 87, 179-181. https://doi.org/10.1016/j.bbi.2020.05.054
Parry, A. H., Wani, A. H., & Yaseen, M. (2020). Neurological Dysfunction in Coronavirus Disease-19 (COVID-19). Academic radiology, 27(9), 1329-1330. https://doi.org/10.1016/j.acra.2020.05.024
Pedicelli, A., Valente, I., Pilato, F., Distefano, M., & Colosimo, C. (2020). Stroke priorities during COVID-19 outbreak: acting both fast and safe. Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association, 29(8), 104922. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104922
Pinna, P., Grewal, P., Hall, J. P., Tavarez, T., Dafer, R. M., Garg, R., Osteraas, N. D., Pellack, D. R., Asthana, A., Fegan, K., Patel, V., Conners, J. J., John, S., & Silva, I. D. (2020). Neurological manifestations and COVID-19: Experiences from a tertiary care center at the Frontline. Journal of the neurological sciences, 415, 116969. https://doi.org/10.1016/j.jns.2020.116969
Rábano-Suárez, P., Bermejo-Guerrero, L., Méndez-Guerrero, A., Parra-Serrano, J., Toledo-Alfocea, D., Sánchez-Tejerina, D., Santos-Fernández, T., Folgueira-López, M. D., Gutiérrez-Gutiérrez, J., Ayuso-García, B., González de la Aleja, J., & Benito-León, J. (2020). Generalized myoclonus in COVID-19. Neurology, 95(6), e767-e772. https://doi.org/10.1212/WNL.0000000000009829
Ramos, F. J. H., García, A. P, & Hernández, M. D. J. (2020). Neurology during the pandemic. Is COVID-19 changing the organisation of Neurology Departments? Neurologia (Barcelona, Spain), 35(4), 269-271. https://doi.org/10.1016/j.nrl.2020.04.009
Rejdak, K., & Grieb, P. (2020). Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, Parkinsonism and cognitive impairment. Multiple sclerosis and related disorders, 42, 102163. https://doi.org/10.1016/j.msard.2020.102163
Román, G. C., Spencer, P. S., Reis, J., Buguet, A., Faris, M., Katrak, S. M., Láinez, M., Medina, M. T., Meshram, C., Mizusawa, H., Öztürk, S., Wasay, M., & WFN Environmental Neurology Specialty Group (2020). The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries. Journal of the neurological sciences, 414, 116884. https://doi.org/10.1016/j.jns.2020.116884
Safavi, F., Nourbakhsh, B., & Azimi, A. R. (2020). B-cell depleting therapies may affect susceptibility to acute respiratory illness among patients with multiple sclerosis during the early COVID-19 epidemic in Iran. Multiple sclerosis and related disorders, 43, 102195. https://doi.org/10.1016/j.msard.2020.102195
San-Juan, D., Jiménez, C. R., Camilli, C. X., de la Cruz Reyes, L. A., Galindo, E., Burbano, G., Penela, M. M., Perassolo, M. B., Valdéz, A. T., Godoy, J. G., Moreira, A. L., & Kimaid, P. (2020). Guidance for clinical neurophysiology examination throughout the COVID-19 pandemic. Latin American chapter of the IFCN task force - COVID-19. Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology, 131(7), 1589-1598. https://doi.org/10.1016/j.clinph.2020.04.011
Scullen, T., Keen, J., Mathkour, M., Dumont, A. S., & Kahn, L. (2020). Coronavirus 2019 (COVID-19)-Associated Encephalopathies and Cerebrovascular Disease: The New Orleans Experience. World neurosurgery, 141, e437-e446. https://doi.org/10.1016/j.wneu.2020.05.192
Serrano-Castro, P. J., Estivill-Torrús, G., Cabezudo-García, P., Reyes-Bueno, J. A., Ciano Petersen, N.,… & Rodríguez de Fonseca, F. (2020). Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic? Neurologia (Barcelona, Spain), 35(4), 245-251. https://doi.org/10.1016/j.nrl.2020.04.002
Sher, Y., Rabkin, B., Maldonado, J. R., & Mohabir, P. (2020). COVID-19 associated hyperactive intensive care unit delirium with proposed pathophysiology and treatment: a case report. Psychosomatics, 61(5), 544. https://doi.org/10.1016/j.psym.2020.05.007
Singh, A. K., Bhushan, B., Maurya, A., Mishra, G., Singh, S. K., & Awasthi, R. (2020). Novel coronavirus disease 2019 (COVID-19) and neurodegenerative disorders. Dermatologic therapy, 33(4), e13591. https://doi.org/10.1111/dth.13591
Sousa, L. M. M., Marques-Vieira, C. M. A., Severino, S. S. P., & Antunes, A. V. (2017). A metodologia de revisão integrativa da literatura em enfermagem. Revista Investigação em Enfermagem 21(2), 17-26. http://www.sinaisvitais.pt/images/stories/Rie/RIE21.pdf#page=17
Troyer, E. A., Kohn, J. N., & Hong, S. (2020). Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms. Brain, behavior, and immunity, 87, 34-39. https://doi.org/10.1016/j.bbi.2020.04.027
World Health Organization. (2020). Coronavírus (COVID-19) Dashboard. https://covid19.who.int/.
Yashavantha Rao, H. C., & Jayabaskaran, C. (2020). The emergence of a novel coronavirus (SARS-CoV-2) disease and their neuroinvasive propensity may affect in COVID-19 patients. Journal of medical virology, 92(7), 786-790. https://doi.org/10.1002/jmv.25918
Zayet, S., Lepiller, Q., Zahra, H., Royer, P. Y., Toko, L., Gendrin, V., & Klopfenstein, T. (2020). Clinical features of COVID-19 and influenza: a comparative study on Nord Franche-Comte cluster. Microbes and infection, 22(9), 481-488. https://doi.org/10.1016/j.micinf.2020.05.016
Zhang, Y., Geng, X., Tan, Y., Li, Q., Xu, C., Xu, J., Hao, L., Zeng, Z., Luo, X., Liu, F., & Wang, H. (2020). New understanding of the damage of SARS-CoV-2 infection outside the respiratory system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 127, 110195. https://doi.org/10.1016/j.biopha.2020.110195
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2022 Tahissa Frota Cavalcante; Daniel Freitas Oliveira Damasceno; José Erivelton de Souza Maciel Ferreira; Raphaella Castro Jansen; Eloise da Silva Barbosa; Rafaella Pessoa Moreira; Huana Carolina Cândido Morais
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
1) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
2) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
3) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.
