Relação entre Parâmetros Hematológicos e Bioquímicos por dias de Sintomas em Pacientes Internados com síndrome gripal e COVID-19

Autores

DOI:

https://doi.org/10.33448/rsd-v11i4.27439

Palavras-chave:

COVID-19; SARS-CoV-2; Exames e diagnósticos laboratoriais; Biomarcadores.

Resumo

Além da síndrome respiratória aguda causada pela COVID-19, o processo inflamatório exacerbado acarreta distúrbios sistêmicos de coagulação, distúrbios cardiovasculares agudos, insuficiência renal aguda, alterações metabólicas e outras manifestações clínicas, aumentando a mortalidade de pacientes com as formas graves da doença. O desenvolvimento de vacinas e medicamentos, bem como de biomarcadores eficazes no diagnóstico e tratamento adequado das formas graves da doença se tornaram prioridade para a comunidade científica e médica. O monitoramento de parâmetros hematológicos e bioquímicos realizados diariamente em pacientes acometidos pela COVID-19, fornecem informações sobre as condições de saúde dos pacientes, sendo de grande importância na evolução da doença. Diante disso, avaliamos os exames laboratoriais de 398 pacientes positivos e negativos para COVID-19 internados em hospitais de Uberaba, provenientes da Macrorregião do Triângulo Sul, estado de Minas Gerais, com população de 800 mil habitantes. Em nossos resultados observamos que os pacientes que foram a óbito apresentaram anemia, leucocitose com neutrofilia, aumento de PCR, ureia e creatinina a partir do 5°, 6° dia de sintomas, e linfopenia no 1° dia. Na gasometria, o pH, SaO2 e PO2 estavam reduzidos desde o 1° dia de sintomas nos pacientes que foram a óbito, sendo que o pH se manteve reduzido até o desfecho clínico. Alterações também foram observadas na dosagem de DHL, TTPa, albumina e eletrólitos. Nossos resultados evidenciam que os exames laboratoriais podem ser úteis como biomarcadores de gravidade já nos primeiros dias de sintomas.

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26/03/2022

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SILVA, D. A. A. da .; ANDRADE-SILVA, L. E. de; DESIDÉRIO, C. S. .; FARNESI DE ASSUNÇÃO, T. S. .; OLIVEIRA, A. C. de M. .; TREVISAN, R. O. .; SANTOS, M. M. .; HELMO, F. R. .; BARBOSA, L. M. .; COSTA-MADEIRA, J. C. .; BARBOSA, R. M. .; BORGES, A. V. B. e .; CUNHA, A. C. C. H. .; PEREIRA, L. Q. .; BOVI, W. G. .; BUENO, G. F. .; MUNDIM, F. V. .; MONTEIRO, I. B. .; FERREIRA, Y. M. .; MACHADO, G. H. .; PAIM, K. F. .; MORAES-SOUZA, H. .; OLIVEIRA, C. J. F. .; SILVA, M. V. da .; RODRIGUES, V. . Relação entre Parâmetros Hematológicos e Bioquímicos por dias de Sintomas em Pacientes Internados com síndrome gripal e COVID-19. Research, Society and Development, [S. l.], v. 11, n. 4, p. e54411427439, 2022. DOI: 10.33448/rsd-v11i4.27439. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27439. Acesso em: 22 nov. 2024.

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Copyright (c) 2022 Djalma Alexandre Alves da Silva; Leonardo Eurípedes de Andrade-Silva; Chamberttan Souza Desidério; Thais Soares Farnesi de Assunção; Ana Carolina de Morais Oliveira; Rafael Obata Trevisan; Malu Mateus Santos; Fernanda Rodrigues Helmo; Laís Milagres Barbosa; Juliana Cristina Costa-Madeira; Rafaela Miranda Barbosa; Anna Victória Bernardes e Borges; Andrezza Cristina Cancian Hortolani Cunha; Loren Queli Pereira; Weslley Guimarães Bovi; Giovanna Ferreira Bueno; Fabiano Vilela Mundim; Ivan Borges Monteiro; Yulsef Moura Ferreira; Guilherme Henrique Machado; Kennio Ferreira Paim; Hélio Moraes-Souza; Carlo José Freire Oliveira; Marcos Vinicius da Silva; Virmondes Rodrigues

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