Pretreatment neutrophil-lymphocyte ratio has prognosis value in breast cancer patients

Sandra Helena Kaznowski da Silva; Livia Costa de Oliveira; Wilza Arantes Ferreira  Peres; Emanuelly Varea Maria  Wiegert; Rachel Souza Thompson Motta; Naira  Freire da  Silva; Márcia Soares da Mota e Silva  Lopes

doi:10.33448/rsd-v11i9.31783

Autores

Sandra Helena Kaznowski da Silva José Alencar Gomes da Silva National Cancer Institute https://orcid.org/0000-0001-8935-1760
Livia Costa de Oliveira José Alencar Gomes da Silva National Cancer Institute https://orcid.org/0000-0002-5052-1846
Wilza Arantes Ferreira Peres Federal University of Rio de Janeiro https://orcid.org/0000-0003-0269-5363
Emanuelly Varea Maria Wiegert José Alencar Gomes da Silva National Cancer Institute https://orcid.org/0000-0001-5904-5287
Rachel Souza Thompson Motta José Alencar Gomes da Silva National Cancer Institute https://orcid.org/0000-0002-7861-8519
Naira Freire da Silva José Alencar Gomes da Silva National Cancer Institute https://orcid.org/0000-0002-7176-1857
Márcia Soares da Mota e Silva Lopes Federal University of Rio de Janeiro https://orcid.org/0000-0001-5721-3750

DOI:

https://doi.org/10.33448/rsd-v11i9.31783

Palavras-chave:

Câncer de mama; Inflamação; Biomarcadores; Prognóstico; Sobrevida.

Resumo

Objetivos: Este estudo teve como objetivo determinar o valor prognóstico dos índices inflamatórios pré-tratamento relação neutrófilo-linfócito, relação linfócito-monócito e relação plaqueta-linfócito no câncer de mama. Métodos: Uma coorte retrospectiva de pacientes com câncer de mama em tratamento em um hospital especializado em câncer foi coletada a partir de 2016. Hemogramas completos pré-tratamento foram avaliados para avaliar os índices inflamatórios. A variável de desfecho foi a sobrevida global em 5 anos. Curvas de Kaplan-Meier, teste de log-rank e regressão de Cox (hazard ratio; intervalo de confiança de 95%) foram usados. Resultados: Um total de 312 mulheres (idade média de 51,9 anos; grau histopatológico II 61,6%; estágio do tumor III 50,0%) foram incluídas no estudo. Destes, 169 (54,2%) morreram em 5 anos, a maioria com relação neutrófilo-linfócito ≥ 2,5 (62,5%; p= 0,002), graus histopatológicos II e III (60,4%; p= 0,024), tumores mais avançados (87,7%; p<0,001) e sobrevida global significativamente menor. Razão neutrófilos-linfócitos ≥ 2,5 (hazard ratio, 1,53; IC 95%, 1,11-2,11) foi um fator prognóstico independente para a sobrevida global. Além disso, os graus histopatológicos II (hazard ratio, 3,53; intervalo de confiança de 95%, 1,29-9,68) e estágio III (hazard ratio, 2,50; intervalo de confiança de 95%, 1,45-4,34) e estágio IV (hazard ratio, 6,07; 95% intervalo de confiança, 3,43-10,73) demonstrou poder preditivo. Conclusão: A relação neutrófilos-linfócitos pré-tratamento foi considerada um preditor útil de sobrevida global no câncer de mama.

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A relação neutrófilo-linfócito pré-tratamento tem valor prognóstico em pacientes com câncer de mama

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