O efeito dos agentes quimioterápicos sobre o periodonto: revisão narrativa de literatura
DOI:
https://doi.org/10.33448/rsd-v11i10.32408Palavras-chave:
Agentes antineoplásicos; Doenças periodontais; Gengivite; Periodontite; Perda do osso alveolar.Resumo
Objetivo: O objetivo deste trabalho é descrever uma revisão narrativa de literatura sobre os efeitos dos agentes quimioterápicos no periodonto e salientar sobre a importância clínica dos cirurgiões dentistas durante a terapia multidisciplinar em pacientes oncológicos. Metodologia: Uma pesquisa bibliográfica exploratória foi realizada nas bases de dados eletrônicas Pubmed/Medline, Embase, Scopus e Scielo, utilizando os termos de busca “chemotherapy and periodontitis”, “chemotherapy and gingivitis” e “chemotherapy and periodontal disease”, sendo considerado os artigos publicados até junho de 2022. Resultados e discussão: Os quimioterápicos não atuam sobre células específicas, eles afetam células de rápida proliferação celular e causam citotoxicidade várias células do tecido conjuntivo. Desta forma, os quimioterápicos causam destruição do epitélio juncional e exacerbam o processo inflamatório do tecido conjuntivo gengival. Quando a periodontite que ocorre pela interação placa bacteriana e o hospedeiro se instala, os quimioterápicos agravam sua progressão. Além disso, quimioterápicos podem afetar os tecidos periodontais de maneira indireta por causar xerostomia e aumentar a quantidade de bactérias da boca. As doenças periodontais são fatores de risco para doenças sistêmicas como: doenças cardiovasculares, doenças do trato respiratório, diabetes, doença de Alzheimer e resultados adversos da gravidez e cabe ao cirurgião dentista da equipe multidisciplinar acompanhar e identificar possíveis riscos no tratamento bucal de pacientes oncológicos. Conclusão: Dentro dos limites da presente revisão de literatura, pode-se concluir que os tecidos periodontais são agredidos pela utilização dos quimioterápicos e medidas de prevenção ou formas de tratamento devem ser levadas em consideração pelo cirurgião dentista da equipe multidisciplinar oncológica.
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Copyright (c) 2022 David Jonathan Rodrigues Gusman; Priscila Arisa Sasaki; Paula Lazilha Faleiros; Patricia Monteiro Seraphim; Christine Men Martins; Bruna Millena da Silva; Amanda Munarolo Piacenza de Oliveira; Eder da Silva Dolens; Juliano Milanezi de Almeida
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Autores que publicam nesta revista concordam com os seguintes termos:
1) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
2) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
3) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.
