Efeitos da dieta no dano de DNA: revisão crítica
DOI:
https://doi.org/10.33448/rsd-v9i6.3364Palavras-chave:
Nutrientes; DNA; Ensaio cometa; Nutrigenética.Resumo
O consumo alimentar envolve interações complexas entre nutrientes e não nutriente, além disso, os componentes da dieta podem influenciar na estrutura e funcionalidade do DNA e consequentemente na atividade dos genes, interferindo na saúde humana. A integridade e estabilidade do DNA são essenciais para a vida, enquanto, o dano no DNA contribui, principalmente, para o desenvolvimento de diferentes doenças como o câncer. O presente estudo objetivou revisar a literatura acerca da influencia dos fatores dietéticos e padrões alimentares e a presença de dano de DNA, através do ensaio cometa, em estudo publicados na última década. Foi realizado uma revisão da literatura utilizando os bancos de dados PubMed, LILACS e Scielo, com os termos “ensaio cometa”, “dieta” e “dietético” e equivalentes em inglês. A revisão identificou 647 estudos, após aplicar os critérios de inclusão e exclusão, 28 artigos foram incluídos na revisão. Observou-se boa qualidade metodológica nos estudos incluídos e uma escassos de estudos que avaliassem o padrão alimentar e os danos ao DNA. Em geral, o consumo de frutas e vegetais e a suplementação de compostos dietéticos isolados ou multivitamínicos apresentaram maior impacto positivo sobre o dano de DNA.
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