Jejum intermitente associado ao café melhora o perfil lipídico e esteatose hepática em ratos wistar hiperlipidêmicos

Fernanda Oliveira  Pignaton; Vivian Michele  Lourenço; Karla Lírio  Soares; Arthur Merigueti de Souza  Costa; Ewelyne Miranda  Lima; Marcio Fronza; Rodrigo Scherer

doi:10.33448/rsd-v11i16.38061

Autores

Fernanda Oliveira Pignaton Universidade Vila Velha https://orcid.org/0000-0002-5948-8771
Vivian Michele Lourenço Universidade Vila Velha https://orcid.org/0000-0002-8305-8640
Karla Lírio Soares Universidade Vila Velha https://orcid.org/0000-0002-3939-8613
Arthur Merigueti de Souza Costa Universidade Vila Velha https://orcid.org/0000-0002-6295-0330
Ewelyne Miranda Lima Universidade Vila Velha https://orcid.org/0000-0003-1497-6111
Marcio Fronza Universidade Vila Velha https://orcid.org/0000-0002-7316-8598
Rodrigo Scherer Universidade Vila Velha https://orcid.org/0000-0001-7656-0248

DOI:

https://doi.org/10.33448/rsd-v11i16.38061

Palavras-chave:

Jejum; Obesidade; Café; Colesterol; HDL; Síndrome metabólica.

Resumo

O objetivo deste estudo foi avaliar a associação entre o jejum intermitente (IF) e a ingestão de café em ratos Wistar pré-tratados com dieta hiperlipídica. Foram utilizados ratos Wistar, recém-nascidos, distribuídos aleatoriamente em 4 grupos: Controle (CO, Ração comercial), Controle+Café (CA, ração comercial+café), Jejum (IF, 24 horas alimentação/24 horas de jejum), Jejum+Café (IFCA, 24 horas alimentação/24 horas jejum+café). Os animais foram pré-tratados com dieta hiperlipidica por 30 dias. O café administrado nos animais foi 100% Arábica, na dose de 0,5 mL por gavagem diariamente. O peso foi aferido semanalmente durante todo o experimento e após a eutanasia foram retiradas e pesadas as gorduras subcutâneas e visceral. Foram analisadas as taxas de glicose e insulina, perfil lipídico e a histologia hepática. Os grupos que fizeram jejum apresentaram resultados significativamente menores no ganho de peso e de massa gorda, melhor perfil lipídico e menor deposição de gordura hepática. Observou-se menor deposição de colágeno nos grupos que ingeriram café, assim com um menor teor de umidade. A partir dos resultados obtidos, pode-se concluir que a associação das intervenções pode ser benéfica na redução de ganho de peso e de gordura corporal, além de apresentar efeito sinérgico na redução da esteatose hepática em ratos pré-tratados com dieta hiperlipídica.

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Jejum intermitente associado ao café melhora o perfil lipídico e esteatose hepática em ratos wistar hiperlipidêmicos

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