O papel do concentrado de complexo protrombrínico no manejo da coagulopatia induzida por trauma: uma revisão integrativa

Autores

DOI:

https://doi.org/10.33448/rsd-v12i3.40283

Palavras-chave:

Sangramento; Transtornos da Coagulação Sanguínea; Protrombina.

Resumo

Introdução: O trauma é uma doença que vitimiza quase 6 milhões de pessoas todos os anos. O sangramento decorrente do trauma desencadeia uma coagulopatia complexa, que necessita de tratamento imediato para melhorar a sobrevida do paciente. O tratamento é baseado em remover a fonte de sangramento, utilizar hemoderivados e concentrados de fatores da coagulação, associado com hipotensão permissiva e reposição controlada de fluídos cristaloides. Objetivo: Avaliar os efeitos da utilização dos concentrados de complexo de protrombina no manejo da coagulopatia induzida por trauma no departamento de emergência. Metodologia: este estudo trata-se de uma revisão integrativa da literatura. O mecanismo de busca utilizado dentro das bases de dados foi: (Bleeding OR Hemorrhage OR Hemostasis OR “Blood Coagulation Disorders") AND (“Prothrombin Complex Concentrates”). Foram incluídos artigos de 2017 a 2022, textos completos disponíveis, em inglês, português e espanhol. Foram excluídos cartas, editoriais e relatos de caso, não correspondentes à temática e os duplicados. Resultados: Após a aplicação dos critérios de inclusão e exclusão, 37 artigos foram selecionados para leitura na íntegra, resultando numa amostra final de 15 artigos para compor esta revisão integrativa, sendo nove artigos da MEDLINE, cinco da SCOPUS e um da SCIENCEDirect. Conclusão: O concentrado de complexo de protrombina é um importante adjuvante no manejo da coagulopatia induzida por trauma, devido à capacidade para reduzir a razão normalizada internacional e a mortalidade sem aumentar o risco de eventos tromboembólicos.

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17/02/2023

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SANTOS, M. L. V. dos .; SILVA, H. B. M. da .; MOURA, E. C. R. .; ARAÚJO, F. L. S. M. de .; OLIVEIRA, C. M. B. de .; LEAL, P. da C. . O papel do concentrado de complexo protrombrínico no manejo da coagulopatia induzida por trauma: uma revisão integrativa. Research, Society and Development, [S. l.], v. 12, n. 3, p. e1812340283, 2023. DOI: 10.33448/rsd-v12i3.40283. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40283. Acesso em: 22 nov. 2024.

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Ciências da Saúde