Possíveis mecanismos fisiopatológicos da disgeusia associada à infecção por SARS-CoV-2 – Revisão de literatura

Autores

DOI:

https://doi.org/10.33448/rsd-v12i3.40424

Palavras-chave:

Coronavírus; Disgeusia; Ageusia.

Resumo

Desde o início da pandemia da COVID-19, em dezembro de 2019, muitos pacientes infectados relataram alterações de paladar e olfato como primeiros sintomas. O cirurgião-dentista deve estar capacitado para diagnosticar esta sintomatologia e encaminhar o paciente para serviços de saúde especializados. O presente estudo se propôs a realizar uma revisão narrativa sobre a possível patogênese da disgeusia e ageusia em pacientes infectados pelo SARS-CoV-2. Os dados foram coletados a partir de estudos identificados nos bancos de dados BVS, Google Acadêmico, LILACS, PubMed, SciELO e Web of Science, utilizando-se como descritores: disgeusia, ageusia, fisiopatologia e coronavírus. Dentre os possíveis mecanismos para a disgeusia, destacam-se a invasão viral em tecido nervoso, acometimento secundário às alterações de olfato, relação com comorbidades e medicamentos, associação à grande presença do vírus na saliva e sua alta afinidade pelos diversos receptores da enzima conversora de angiotensina-2 presentes na cavidade bucal. Portanto, alterações de paladar são sintomas típicos em pacientes infectados pelo SARS-CoV-2 e que tendem a regredir com o tempo. Entretanto, sua fisiopatologia, mecanismo de ação e prognóstico ainda não são bem estabelecidos, exigindo mais estudos experimentais.

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24/02/2023

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BUENO, M. V. . .; GALVÃO, G. S. .; NEVES, I. L. I.; SCHRÖTER, G. T.; MOREIRA, M. S. .; SANTOS-PAUL, M. A. dos .; CARVALHO, C. M. A. de .; NEVES, R. S.; MONTANO , T. C. P. Possíveis mecanismos fisiopatológicos da disgeusia associada à infecção por SARS-CoV-2 – Revisão de literatura. Research, Society and Development, [S. l.], v. 12, n. 3, p. e6712340424, 2023. DOI: 10.33448/rsd-v12i3.40424. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40424. Acesso em: 23 nov. 2024.

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v. 12 n. 3

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Copyright (c) 2023 Marcus Vinícius Bueno; Gustavo Souza Galvão; Itamara Lucia Itagiba Neves; Gabriella Torres Schröter; Maria Stella Moreira; Marcela Alves dos Santos-Paul; Cíntia Maria Alencar de Carvalho; Ricardo Simões Neves; Tânia Cristina Pedroso Montano

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