Compósitos de hidroxiapatita, alginato e gelatina utilizados para regeneração óssea: uma revisão sistemática
DOI:
https://doi.org/10.33448/rsd-v12i3.40566Palavras-chave:
Regeneração óssea; Material biocompatível; Durapatite; Alginato; gelatina.Resumo
Objetivo: investigar e descrever, por meio de revisão sistemática, o comportamento biológico e o potencial osteogênico de biomateriais compósitos contendo hidroxiapatita (HA), alginato e gelatina, em diferentes associações, após implantação in vivo. Materiais e Métodos: para a busca e seleção dos artigos utilizou-se as bases de dados Medical Literature Analysis and Retrieval System Online (PubMed/MEDLINE) e Scientific Electronic Library Online (SciELO), publicados entre 2012 e 2022, empregando os descritores: “bone regeneration”; “biocompatible material”; “durapatite”; “alginate”; “gelatin”. Inicialmente, foi feita uma associação com o operador booleano “OR” entre os descritores e seus respectivos entry terms, tendo em vista que as plataformas MeSH e DeCS utilizam diferentes termos para referir às mesmas palavras-chave. Posteriormente, empregou-se o operador “AND” em nove associações entre os descritores. Resultados: durante as buscas localizou-se 1939 artigos. Após o emprego dos critérios de inclusão e exclusão, foram incluídos 16 estudos na revisão. Os principais temas encontrados nas buscas foram: HA e Alginato; HA e Gelatina; HA, Alginato e Zinco; HA, Gelatina e células mesenquimais; HA, Alginato e Quitosana; HA, Alginato e Fibrina de seda; HA, Gelatina e dióxido de titânio; HA, Alginato e Gelatina. Observou-se que a HA, quando associada ao alginato ou a gelatina, tem suas propriedades osteogênicas aperfeiçoadas. Considerações Finais: compósitos de HA associados ao alginato e à gelatina proporcionam uma gama de aplicações e estratégias promissoras aplicadas ao reparo ósseo. Os estudos mostraram que estes compósitos apresentaram grande potencial para aplicação na Bioengenharia Tecidual Óssea.
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