Avaliação da duração e do risco de sangramento entre diferentes estratégias de dupla antiagregação plaquetária administradas após a intervenção coronária percutânea: uma revisão de escopo

Autores

DOI:

https://doi.org/10.33448/rsd-v12i8.42867

Palavras-chave:

Terapia antiplaquetária dupla; Inibidores da agregação plaquetária; Hemorragia.

Resumo

Pacientes portadores Síndrome Coronariana Aguda (SCA) necessitam de implante de stent farmacológico após a intervenção coronária percutânea (ICP), associado à administração de dupla terapia antiplaquetária (TDAP) para a redução do risco trombótico. Considerando a avaliação entre a proteção isquêmica e a chance de eventos hemorrágicos, novas estratégias de TDAP têm sido utilizadas, permitindo-se a prevenção de possíveis desfechos deletérios. O presente estudo objetiva avaliar a duração e o risco de sangramento entre diferentes estratégias de TDAP administradas após a ICP. Para essa revisão de escopo, realizada através das plataformas PubMed e ScienceDirect, entre os anos de 2020 e 2023, os descritores eleitos foram: '’Platelet Aggregation Inhibitors'', ‘’Percutaneous Coronary Intervention’’ e ‘’Hemorrhage’’. Os critérios de inclusão consistiram em (1) avaliação da duração e do risco de sangramento em distintas estratégias de TDAP (2) análise entre diferentes tipos de antiagregantes plaquetários (3) estudos que abordaram o seguimento e o manejo clínico (4) artigos em inglês e português. Os critérios de exclusão consistiram em inadequações ao tema, relatos de casos, editoriais, revisões simples, estudos com animais, além de textos fora do limite temporal. Regimes de TDAP prolongada e de longa duração apresentaram maior proteção isquêmica e maior risco de sangramento. Regimes de curta ou curtíssima duração estiveram associados à redução das taxas de sangramento maior, sendo benéficos aos pacientes idosos ou trombocitopênicos. O manejo de casos com alto risco trombótico e hemorrágico, assim como a utilização de escores preditivos permanecem como tópicos controversos a serem elucidados através de novos estudos.

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17/08/2023

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SANTOS, T. L. .; PARREIRA, W. da S. P. .; FRACARO, A. C.; CAMPOS, D. R. .; PAVONI, B. de C. .; BEZERRA NETO, P. D. .; SADY, L. M. da R. .; PINHO, L. A. de .; PEREIRA, L. F. B. . Avaliação da duração e do risco de sangramento entre diferentes estratégias de dupla antiagregação plaquetária administradas após a intervenção coronária percutânea: uma revisão de escopo. Research, Society and Development, [S. l.], v. 12, n. 8, p. e7112842867, 2023. DOI: 10.33448/rsd-v12i8.42867. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/42867. Acesso em: 17 jul. 2024.

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v. 12 n. 8

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Ciências da Saúde

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Copyright (c) 2023 Trinnye Luizze Santos; Walquiria da Silva Pedra Parreira; Augusto Cesar Fracaro; Davi Resende Campos; Bianca de Campos Pavoni; Pedro Dias Bezerra Neto; Louise Mota da Rocha Sady; Lênio Airam de Pinho; Lucas França Belfort Pereira

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