A influência dos disruptores endócrinos na saúde feminina

Autores

DOI:

https://doi.org/10.33448/rsd-v13i12.47579

Palavras-chave:

Disruptores endócrinos; Endometriose; Síndrome do Ovário Policístico; Diabetes tipo 2; Câncer.

Resumo

Introdução: Os Disruptores Endócrinos (DEs) são produtos químicos de fácil acesso humano e presentes no cotidiano. Sendo assim, esses produtos químicos como ftalatos, bisfenol A (BPA), bisfenol S (BPS), entre outros, estão associados a algumas doenças como diabetes e condições do aparelho reprodutivo feminino, como a endometriose e Síndrome do Ovário Policístico (SOP). Objetivo: Avaliar as influências potenciais que os disruptores endócrinos apresentam sobre a saúde feminina. Metodologia: Trata-se de uma revisão narrativa a partir da análise de artigos de revisão e estudos científicos publicados entre 2014 e 2024, sendo que as bases de dados utilizadas foram PubMed, Scielo e EBSCO, de forma que os critérios para a inclusão dos artigos foi baseada na análise de conteúdos, análise do título e consequente relevância para a temática; os descritores em saúde utilizados foram Síndrome do Ovário Policístico (SOP), disruptores endócrinos, diabetes tipo 2. Resultados: Os artigos selecionados analisados demonstram dados indicadores de possível relação entre o contato com os DEs e a incidência de diabetes, SOP, endometriose, câncer e infertilidade. Conclusão: Este estudo elucidou uma significativa associação entre a exposição aos DEs com doenças prevalentes na sociedade, principalmente para o público feminino, como SOP, endometriose, diabetes, obesidade e câncer.

Referências

Adeyi, A. A., & Babalola, B. A. (2019). Bisphenol-A (BPA) in foods commonly consumed in Southwest Nigeria and its human health risk. Scientific Reports, 9 (1), 17458. https://doi.org/10.1038/s41598-019-53790-2

Ahn, C., & Jeung, E.-B. (2023). Endocrine-disrupting chemicals and disease endpoints. International Journal of Molecular Sciences, 24 (6), 5342. https://doi.org/10.3390/ijms24065342

Almeida, S., et al. (2018). Bisphenol A: Food exposure and impact on human health. Comprehensive Reviews in Food Science & Food Safety, 17 (6), 1503–17. https://doi.org/10.1111/1541-4337.12388

Alves-Ferreira, J., et al. (2024). Pesticide water variability and prioritization: The first steps towards improving water management strategies in irrigation hydro-agriculture areas. Science of The Total Environment, 917, 170304. https://doi.org/10.1016/j.scitotenv.2024.170304

Bellato, L. R., Oliveira, L. A. de, & Cupertino, M. do C. (2019). Análise dos impactos na saúde humana advindos da exposição a contaminantes ambientais orgânicos e interferentes endócrinos. Brazilian Journal of Surgery & Clinical Research, 28 (3), 49–58. https://search.ebscohost.com/login.aspx?direct=true&db=asn&AN=143500736&lang=pt-br&site=ehost-live.

Bueno, É. S. B., Brandão, et al. (2024). Assessment of prostate tissue remodeling in rats exposed to bisphenol A and the phytoestrogens genistein and indole-3-carbinol during the perinatal period. Ciência Rural, 54 (8), 1–9. https://doi.org/10.1590/0103-8478cr20230205

Burns, K., et al. (2024). Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry. BMC Genomics, 25 (1), 208. https://doi.org/10.1186/s12864-024-09990-w

Cao, X.-L., et al. (2015). Determination of free and total bisphenol A in human milk samples from Canadian women using a sensitive and selective GC-MS method. Food Additives & Contaminants: Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment, 32 (1), 120–125. https://doi.org/10.1080/19440049.2014.980855.

Calcaterra, V., et al. (2024). Evaluating phthalates and bisphenol in foods: Risks for precocious puberty and early-onset obesity. Nutrients, 16 (16), 2732. https://doi.org/10.3390/nu16162732.

Carli, F., et al. (2022). Exposure to endocrine disruptors (Di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA)) in women from different residing areas in Italy: Data from the LIFE PERSUADED project. International Journal of Molecular Sciences, 23 (24), 16012. https://doi.org/10.3390/ijms232416012.

Casarin, S. T. et al. (2020). Tipos de revisão de literatura: considerações das editoras do Journal of Nursing and Health. Journal of Nursing and Health. 10 (5). https://periodicos.ufpel.edu.br/index.php/enfermagem/article/view/19924.

Cavalcante, L. T. C. & Oliveira, A. A. S. (2020). Métodos de revisão bibliográfica nos estudos científicos. Psicol. Rev. 26 (1). https://doi.org/10.5752/P.1678-9563.2020v26n1p82-100.

Cifre-Herrando, M., Roselló-Márquez, G., & García-Antón, J. (2024). Is photoelectrocatalysis an efficient process to degrade endocrine disruptors chemicals? Environmental Toxicology and Pharmacology, 107, 104420. https://doi.org/10.1016/j.etap.2024.104420

Daian, L. M., et al. (2023). Modulation of unfolded protein response restores survival and function of β-cells exposed to the endocrine disruptor bisphenol A. International Journal of Molecular Sciences, 24(3), 2023. https://doi.org/10.3390/ijms24032023.

Daronch, O. T., et al. (2020). Contaminação em larga escala por Bisfenol-A: estamos conscientes do risco e formas de exposição? Ciência & Saúde Coletiva, 25, 4339–4345. https://doi.org/10.1590/1413-812320202511.01852018

De Paula, L. C. P., & Alves, C. (2024). Food packaging and endocrine disruptors. Jornal de Pediatria, 100, S40–S47. https://doi.org/10.1016/j.jped.2023.09.010.

Fabozzi, G., et al. (2022). Endocrine-disrupting chemicals, gut microbiota, and human (in)fertility—It is time to consider the triad. Cells, 11(21), 3335. https://doi.org/10.3390/cells11213335.

Filippone, A., et al. (2023). Endocrine disruptors in food, estrobolome, and breast cancer. Journal of Clinical Medicine, 12 (9), 3158. https://doi.org/10.3390/jcm12093158.

García-Peñarrubia, P., Herrera, M., & García-Serrano, A. (2020). Hypothetical roadmap towards endometriosis: Prenatal endocrine-disrupting chemical pollutant exposure, anogenital distance, gut-genital microbiota, and subclinical infections. Human Reproduction Update, 26 (2), 214–46. https://doi.org/10.1093/humupd/dmz044

Gea, M., et al. (2022). Assessment of five pesticides as endocrine-disrupting chemicals: Effects on estrogen receptors and aromatase. International Journal of Environmental Research and Public Health, 19 (4), 1959. https://doi.org/10.3390/ijerph19041959.

Gómez-Mercado, C. A., et al. (2018). Exposición a bisfenol A (BPA) en mujeres embarazadas y su relación con la obesidad en sus hijos: Revisión sistemática. Revista Facultad Nacional de Salud Pública, 36 (1), 66–74. https://doi.org/10.17533/udea.rfnsp.v36n1a08.

Hall, K. D. (2023). From dearth to excess: The rise of obesity in an ultra-processed food system. Philosophical Transactions of the Royal Society B: Biological Sciences, 378 (1885), 20220214. https://doi.org/10.1098/rstb.2022.0214.

Hu, Y., et al. (2018). The association between the environmental endocrine disruptor bisphenol A and polycystic ovary syndrome: A systematic review and meta-analysis. Gynecological Endocrinology, 34 (5), 370–377. https://doi.org/10.1080/09513590.2017.1405931.

Interdonato, L., et al. (2023). Endocrine disruptor compounds in environment: Focus on women’s reproductive health and endometriosis. International Journal of Molecular Sciences, 24 (6), 5682. https://doi.org/10.3390/ijms24065682.

Johns, L. E., et al. (2017). Urinary BPA and phthalate metabolite concentrations and plasma vitamin D levels in pregnant women: A repeated measures analysis. Environmental Health Perspectives, 125 (8), 1–9. https://doi.org/10.1289/EHP1178.

Keskesiadou, G.-N., et al. (2024). Endocrine-disrupting chemicals and the development of diabetes mellitus type 1: A 5-year systematic review. International Journal of Molecular Sciences, 25 (18), 10111. https://doi.org/10.3390/ijms251810111.

Khan, M. R., Saleem, M., Khan, M. S., & Ahmed, S. (2021). Trace analysis of environmental endocrine disrupting contaminant bisphenol A in canned, glass, and polyethylene terephthalate plastic carbonated beverages of diverse flavors and origin. Food Science and Technology/Ciência e Tecnologia de Alimentos, 41 (1), 210–7. https://doi.org/10.1590/fst.03420.

Kim, K. (2024). The role of endocrine disruption chemical-regulated aryl hydrocarbon receptor activity in the pathogenesis of pancreatic diseases and cancer. International Journal of Molecular Sciences, 25 (7), 3818. https://doi.org/10.3390/ijms25073818.

Kowalczyk, M., et al. (2023). Application of in vitro models for studying the mechanisms underlying the obesogenic action of endocrine-disrupting chemicals (EDCs) as food contaminants—A review. International Journal of Molecular Sciences, 24 (2), 1083. https://doi.org/10.3390/ijms24021083.

Lin, Z., Zhang, X., Wang, Y., & Li, W. (2017). A study on environmental bisphenol A pollution in plastics industry areas. Water, Air, & Soil Pollution, 228(3), 1–9. https://doi.org/10.1007/s11270-017-3277-9.

Lima do Nascimento, M. T., Silva, A. R., Oliveira, J. L., & Almeida, P. S. (2022). Estrogenic activity and endocrine disruptor compounds determined in Guanabara Bay (Brazil) by yeast estrogen screen assays and chemical analyses. Anuário do Instituto de Geociências, 45, 1–11. https://doi.org/10.11137/1982-3908_2022_45_45450

Land, K. L., Hines, C. J., Hornung, M. W., & Henningsen, K. M. (2022). The effects of endocrine-disrupting chemicals on ovarian- and ovulation-related fertility outcomes. Molecular Reproduction and Development, 89(12), 608–631. https://doi.org/10.1002/mrd.23652.

Landrigan, P., Carlson, A., Diamanti-Kandarakis, E., & Giordano, G. (2023). The Minderoo-Monaco Commission on plastics and human health. Annals of Global Health, 89 (1), 23. https://doi.org/10.5334/aogh.4056.

Maša, K., Paternoster, C., Milanesi, E., & Montini, A. (2020). Triclocarban, triclosan, bromochlorophene, chlorophene, and climbazole effects on nuclear receptors: An in silico and in vitro study. Environmental Health Perspectives, 128 (10), 107005-1–107005–17. https://doi.org/10.1289/EHP6596.

Miranda, R. A., Silva, A. F., Oliveira, M. A., Santos, F. P., & Souza, J. P. (2022). Pesticides as endocrine disruptors: Programming for obesity and diabetes. Endocrine, 79 (3), 437–47. https://doi.org/10.1007/s12020-022-03229-y.

Mitra, T., Roy, P., & Banerjee, A. (2024). Endocrine disrupting chemicals: Gestational diabetes and beyond. Diabetology & Metabolic Syndrome, 16(1), 95. https://doi.org/10.1186/s13098-024-01317-9.

Mohamad Haron, D. E., Zainuddin, Z., & Ali, Z. (2023). PFAS, bisphenol, and paraben in Malaysian food and estimated dietary intake. Food Additives & Contaminants: Part B, 16(2), 161–175. https://doi.org/10.1080/19393210.2023.2188611.

Mole, B. (2015). BPA replacements found in people. Science News, 188(7), 12. https://doi.org/10.1002/scin.2015.188007013.

Mornagui, B., Bouzid, F., Ghram, A., & Hammami, M. (2022). Bisphenol S favors hepatic steatosis development via an upregulation of liver MCT1 expression and an impairment of the mitochondrial respiratory system. Journal of Cellular Physiology, 237(7), 3057–3068. https://doi.org/10.1002/jcp.30771.

Naspolini, N. F., de Souza, D. L., & Oliveira, D. P. (2021). Maternal consumption of ultra-processed foods and newborn exposure to perfluoroalkyl substances (PFAS). Cadernos de Saúde Pública, 37 (11), e00152021. https://doi.org/10.1590/0102-311X00152021.

Parker, J. (2023). Pathophysiological effects of contemporary lifestyle on evolutionary-conserved survival mechanisms in polycystic ovary syndrome. Life, 13 (4), 1056. https://doi.org/10.3390/life13041056.

Pivonello, C., De Martino, M. U., & Colao, A. (2020). Bisphenol A: An emerging threat to female fertility. Reproductive Biology & Endocrinology, 18 (1), 1–33. https://doi.org/10.1186/s12958-019-0558-8.

Peinado, F. M., Iribarne-Durán, L. M., & Artacho-Cordón, F. (2023). Human exposure to bisphenols, parabens, and benzophenones, and its relationship with the inflammatory response: A systematic review. International Journal of Molecular Sciences, 24(8), 7325. https://doi.org/10.3390/ijms24087325.

Peinado, F. M., García-Álvarez, M., Ruiz, A., & Artacho-Cordón, F. (2023). Expression profiles of genes related to development and progression of endometriosis and their association with paraben and benzophenone exposure. International Journal of Molecular Sciences, 24(23), 16678. https://doi.org/10.3390/ijms242316678.

Pokorska-Niewiada, K., Borawska, M. H., & Kowalska, A. (2022). Levels of trace elements in erythrocytes as endocrine disruptors in obese and nonobese women with polycystic ovary syndrome. International Journal of Environmental Research and Public Health, 19 (2), 976. https://doi.org/10.3390/ijerph1902097.

Puche-Juarez, M., Matar, S. M., & Navarro, C. (2023). The role of endocrine disrupting chemicals in gestation and pregnancy outcomes. Nutrients, 15 (21), 4657. https://doi.org/10.3390/nu15214657.

Quitete, F. T., Pereira, R. C., da Silva, J. M., Santos, D. B., & Lima, R. L. (2024). Long-term exposure to polychlorinated biphenyl 126 induces liver fibrosis and upregulates miR-155 and miR-34a in C57BL/6 mice. PLOS ONE, 19 (8), e0308334. https://doi.org/10.1371/journal.pone.0308334.

Rogers, R. E., Smith, E. A., & Williams, M. J. (2023). Prenatal exposure to diethylstilbestrol has long-lasting, transgenerational impacts on fertility and reproductive development. Toxicological Sciences, 195 (1), 53–60. https://doi.org/10.1093/toxsci/kfad066.

Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta Paul. Enferm. 20 (2). https://doi.org/10.1590/S0103-21002007000200001.

Rumph, J. T., Thomas, M. S., & Brown, A. L. (2020). Environmental endocrine disruptors and endometriosis. In K. L. Sharpe-Timms (Ed.), Animal models for endometriosis (pp. 57–78). Springer International Publishing. https://doi.org/10.1007/978-3-030-51856-1_4.

Santaliz Casiano, A., Taveras, L., & Rodríguez, M. (2022). Endocrine-disrupting chemicals and breast cancer: Disparities in exposure and importance of research inclusivity. Endocrinology, 163(5), bqac034. https://doi.org/10.1210/endocr/bqac034

Silva, A. B. P., Souza, M. J., & Costa, E. (2023). The role of endocrine disruptors in female infertility. Molecular Biology Reports, 50 (8), 7069–88. https://doi.org/10.1007/s11033-023-08583-2

Sirohi, D., Al Ramadhani, R., & Knibbs, L. D. (2021). Environmental exposures to endocrine disrupting chemicals (EDCs) and their role in endometriosis: A systematic literature review. Reviews on Environmental Health, 36 (1), 101–15. https://doi.org/10.1515/reveh-2020-0046

Srnvršnik, T., Virant-Klun, I., & Pinter, B. (2023). Polycystic ovary syndrome and endocrine disruptors (bisphenols, parabens, and triclosan)—A systematic review. Life, 13 (1), 138. https://doi.org/10.3390/life13010138

Daronch, O. T., Chaves, A. A., Almeida, L. M., & Costa, R. A. (2020). Contaminação em larga escala por Bisfenol-A: Estamos conscientes do risco e formas de exposição? Revista Ciência & Saúde Coletiva, 25 (11), 4339–45. https://doi.org/10.1590/1413-812320202511.01852018

Varticovski, L., Pabón, J. P., & Sáenz, L. G. (2022). Endocrine disruptors of sex hormone activities. Molecular and Cellular Endocrinology, 539, 111415.

Zhang, Y., Chen, D., Xu, X., Zhang, W., & Li, Z. (2021). Combined exposure to multiple endocrine disruptors and uterine leiomyomata and endometriosis in US women. Frontiers in Endocrinology, 12, 726876. https://doi.org/10.3389/fendo.2021.7268.

Downloads

Publicado

30/11/2024

Como Citar

GRUBER , G. A. .; ARAUJO, M. I. da C. .; ALMEIDA, S. G. de . A influência dos disruptores endócrinos na saúde feminina. Research, Society and Development, [S. l.], v. 13, n. 12, p. e37131247579, 2024. DOI: 10.33448/rsd-v13i12.47579. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/47579. Acesso em: 7 jan. 2025.

Edição

Seção

Artigos de Revisão