Pesticide exposure and risk of Parkinson’s disease: A case-control study in Northeastern Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v12i3.40691

Keywords:

Pesticides; Parkinson's disease; Neurodegenerative Diseases; Environmental exposure.

Abstract

Parkinson's disease (PD) is an idiopathic neurodegenerative disease, and it has been linked to long-term pesticide exposure. In this study, we aimed to determine whether pesticide exposure was associated with the risk of PD and other neurological manifestations. We conducted a pilot case-control study in patients from two neurology outpatient clinics. PD cases (n = 29) were matched with controls (n = 83) randomly selected from the same outpatient clinics. For data collection, telephone-based interviews were performed using a structured questionnaire. Overall, PD cases were proportionally more exposed to pesticides than the control group, but the association was not statistically significant (OR= 1.92; 95%, CI: 0.77–4.66; p = 0.15). We identified a high prevalence of neurological and psychological symptoms among the study participants, especially among the individuals who reported pesticide exposure. Our results reinforce the importance of further studies investigating the relationship between PD and pesticides to better understand this phenomenon.

Author Biographies

Ricardo Ruan Rocha Santana, Federal University of Sergipe

Department of Medicine. Federal University of Sergipe, Lagarto, Brazil.

Jorge Rhailan Pacífico Sierau, Federal University of Sergipe

Department of Medicine. Federal University of Sergipe, São Cristóvão, Brazil.

Abraão Almeida Santos, University of Florida

University of Florida, West Florida Research and Education Center, Entomology and Nematology Department, Jay, 32565, United States.

José Ronaldo dos Santos, Federal University of Sergipe

Laboratory of Behavioral and Evolutionary Neurobiology, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.

Murilo Marchioro, Federal University of Sergipe

Laboratory of Neurophysiology, Department of Physiology. Federal University of Sergipe, São Cristóvão, SE, Brazil.

Lívia Cristina Rodrigues Ferreira Lins, Federal University of Sergipe

Laboratory of Neurophysiology, Department of Physiology. Federal University of Sergipe, São Cristóvão, SE, Brazil.

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Published

12/03/2023

How to Cite

SANTANA, R. R. R. .; SIERAU, J. R. P. .; SANTOS, A. A. .; SANTOS, J. R. dos; MARCHIORO, M. .; LINS, L. C. R. F. . Pesticide exposure and risk of Parkinson’s disease: A case-control study in Northeastern Brazil. Research, Society and Development, [S. l.], v. 12, n. 3, p. e21012340691, 2023. DOI: 10.33448/rsd-v12i3.40691. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40691. Acesso em: 20 apr. 2024.

Issue

Vol. 12 No. 3

Section

Health Sciences

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Copyright (c) 2023 Ricardo Ruan Rocha Santana; Jorge Rhailan Pacífico Sierau; Abraão Almeida Santos; José Ronaldo dos Santos; Murilo Marchioro; Lívia Cristina Rodrigues Ferreira Lins

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