Pesticide exposure and risk of Parkinson’s disease: A case-control study in Northeastern Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v12i3.40691

Keywords:

Pesticides; Parkinson's disease; Neurodegenerative Diseases; Environmental exposure.

Abstract

Parkinson's disease (PD) is an idiopathic neurodegenerative disease, and it has been linked to long-term pesticide exposure. In this study, we aimed to determine whether pesticide exposure was associated with the risk of PD and other neurological manifestations. We conducted a pilot case-control study in patients from two neurology outpatient clinics. PD cases (n = 29) were matched with controls (n = 83) randomly selected from the same outpatient clinics. For data collection, telephone-based interviews were performed using a structured questionnaire. Overall, PD cases were proportionally more exposed to pesticides than the control group, but the association was not statistically significant (OR= 1.92; 95%, CI: 0.77–4.66; p = 0.15). We identified a high prevalence of neurological and psychological symptoms among the study participants, especially among the individuals who reported pesticide exposure. Our results reinforce the importance of further studies investigating the relationship between PD and pesticides to better understand this phenomenon.

Author Biographies

Ricardo Ruan Rocha Santana, Federal University of Sergipe

Department of Medicine. Federal University of Sergipe, Lagarto, Brazil.

Jorge Rhailan Pacífico Sierau, Federal University of Sergipe

Department of Medicine. Federal University of Sergipe, São Cristóvão, Brazil.

Abraão Almeida Santos, University of Florida

University of Florida, West Florida Research and Education Center, Entomology and Nematology Department, Jay, 32565, United States.

José Ronaldo dos Santos, Federal University of Sergipe

Laboratory of Behavioral and Evolutionary Neurobiology, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.

Murilo Marchioro, Federal University of Sergipe

Laboratory of Neurophysiology, Department of Physiology. Federal University of Sergipe, São Cristóvão, SE, Brazil.

Lívia Cristina Rodrigues Ferreira Lins, Federal University of Sergipe

Laboratory of Neurophysiology, Department of Physiology. Federal University of Sergipe, São Cristóvão, SE, Brazil.

References

Andrew, A. S., Anderson, F. L., Lee, S. L., Von Herrmann, K. M., & Havrda, M. C. (2021). Lifestyle Factors and Parkinson’s Disease Risk in a Rural New England Case-Control Study. Parkinsons Dis, 2021:30–3.

Benarroch, E. E. (2010). Olfactory system: Functional organization and involvement in neurodegenerative disease. Neurology, 75(12):1104–9.

Breckenridge, C. B., Berry, C., Chang, E. T., Sielken, R. L., & Mandel, J. S. (2016). Association between Parkinson’s disease and cigarette smoking, rural living, well-water consumption, farming and pesticide use: Systematic review and meta-analysis. PLoS One, 11(4):1–42.

Brucker, M. C. (2017). Social Determinants of Health. Nurs Womens Health, 21(1):7–8.

Eriguchi, M. et al. (2019). Parkinsonism relating to intoxication with glyphosate. Intern Med, 58(13):1935–8.

Gallo, V. et al. (2019). Exploring causality of the association between smoking and Parkinson’s disease. Int J Epidemiol, 48(3):912–25.

Gu, Q. et al. (2022). The protective role of cigarette smoking against Parkinson’s disease via moderation of the interaction between iron deposition in the nigrostriatal pathway and clinical symptoms. Quant Imaging Med Surg, 12(7):3603–24.

Gunnarsson, L. G., & Bodin, L. (2019). Occupational exposures and neurodegenerative diseases—a systematic literature review and meta-analyses. Int J Environ Res Public Health, 16 (3).

Hou, L. et al. (2018). Hypertension and diagnosis of Parkinson’s disease: A meta-analysis of cohort studies. Front Neurol, 9(3):1–9.

Islam, A., Malik, & M. F. (2018). Toxicity of Pesticides on CNS. J Toxicol Anal, 1(1):7.

Kori, R., Singh, M. K., Jain, A. K., & Yadav, R. S. (2018). Neurochemical and Behavioral Dysfunctions in Pesticide Exposed Farm Workers: A Clinical Outcome. Indian J Clin Biochem, 33(4):372–81.

Llamas-Velasco, S. et al. (2021). Physical activity and risk of Parkinson’s disease and parkinsonism in a prospective population-based study (NEDICES). Prev Med Reports, 23.

Lushchak, V. I., Matviishyn, T. M., Husak, V. V., Storey, J. M., & Storey, K. B. (2018). Pesticide toxicity: A mechanistic approach. EXCLI J, 17:1101–36.

Macfarlane, E., Carey, R., Keegel, T., El-zaemay, S., & Fritschi, L. (2013). Dermal Exposure Associated with Occupational End Use of Pesticides and the Role of Protective Measures. Saf Health Work, 4(3):136–41.

Marras, C., Canning, C. G., & Goldman, S. M. (2019). Environment, lifestyle, and Parkinson’s disease: Implications for prevention in the next decade. Mov Disord, 34(6):801–11.

Marsh, L. (2013). Depression and Parkinson’s Disease: Current Knowledge. Curr Neurol Neurosci Rep, 13(12).

Martínez-Horta, S. et al. (2021). Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease. BMC Neurol, 21(1):1–10.

Medeiros, M. S., Reddy, S., Socal, M., Schumacher-Schuh, A. F., & Mello Rieder, C. R. (2020). Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: An observational study in southern Brazil. Environ Heal A Glob Access Sci Source, 19(1):1–8.

Moisan, F. et al. (2015). Association of parkinson’s disease and its subtypes with agricultural pesticide exposures in men: A case-control study in France. Environ Health Perspect, 123(11):1123–9.

Narayan, S., Liew, Z., Bronstein, J. M., & Ritz, B. (2017). Occupational pesticide use and Parkinson’s disease in the Parkinson Environment Gene (PEG) study. Environ Int, 107(8):266–73.

Naughton, S. X., & Terry, A. J. (2018). Neurotoxicity in acute and repeated organophosphate exposure. Toxicology, 408:101–12.

Negatu, B., Vermeulen, R., Mekonnen, Y., & Kromhout, H. (2018). Neurobehavioural symptoms and acute pesticide poisoning: A cross-sectional study among male pesticide applicators selected from three commercial farming systems in Ethiopia. Occup Environ Med, 75(4):283–9.

Ng, Y. F. et al. (2021). Case-control study of hypertension and Parkinson’s disease. Park Dis, 7(1): 63.

Ong-Artborirak, P., Boonchieng, W., Juntarawijit, Y., & Juntarawijit, C. (2022). Potential Effects on Mental Health Status Associated with Occupational Exposure to Pesticides among Thai Farmers. Int J Environ Res Public Health, 19(15): 9654.

Pouchieu, C. et al. (2018). Pesticide use in agriculture and Parkinson’s disease in the AGRICAN cohort study. Int J Epidemiol, 47(1):299–310.

Quandt, S. A., Walker, F. O., & Talton, J. W. (2017). Olfactory Function in Latino Farmworkers over Two Years: Longitudinal Exploration of Subclinical Neurological Effects of Pesticide Exposure. Physiol Behav, 59(12):1148–1152.

Reichmann, H. (2017). Premotor Diagnosis of Parkinson’s Disease. Neurosci Bull, 33(5):526–34.

Richardson, J. R., Fitsanakis, V., Westerink, R. H. S., & Kanthasamy, A. G. (2019). Neurotoxicity of pesticides. Acta Neuropathol, 138(3):343–62.

Saadat, P., Faramarzi, M., Salimkhani, F., & Khafri, S. (2020). Psychiatric symptoms in patients with Parkinson’s disease and caregivers. Oman Med J, 35(5):1–22.

Santiago, J. A., Bottero, V., & Potashkin, J. A. (2017). Biological and clinical implications of comorbidities in Parkinson’s disease. Front Aging Neurosci, 9(10):1–16.

Shao, C. et al. (2021). Parkinson’s Disease Risk and Alcohol Intake: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies. Front Nutr, 8(10):1–8.

Takahashi, N., & Hashizume, M. (2014). A systematic review of the influence of occupational organophosphate pesticides exposure on neurological impairment. BMJ Open, 4(6).

Weintraub, D., Aarsland, D., Chaudhuri, K. R., & Dobkin, R. D. (2022). The neuropsychiatry of Parkinson’s disease: advances and challenges Daniel. Lancet Neurol, 21(1):89–102.

Yapici, E. H., Bora, H.A., & Kuruoğlu, A. (2017). Depression and parkinson disease: Prevalence, temporal relationship, and determinants. Turkish J Med Sci, 47(2):499–503.

Downloads

Published

12/03/2023

How to Cite

SANTANA, R. R. R. .; SIERAU, J. R. P. .; SANTOS, A. A. .; SANTOS, J. R. dos; MARCHIORO, M. .; LINS, L. C. R. F. . Pesticide exposure and risk of Parkinson’s disease: A case-control study in Northeastern Brazil. Research, Society and Development, [S. l.], v. 12, n. 3, p. e21012340691, 2023. DOI: 10.33448/rsd-v12i3.40691. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40691. Acesso em: 23 nov. 2024.

Issue

Vol. 12 No. 3

Section

Health Sciences

License

Copyright (c) 2023 Ricardo Ruan Rocha Santana; Jorge Rhailan Pacífico Sierau; Abraão Almeida Santos; José Ronaldo dos Santos; Murilo Marchioro; Lívia Cristina Rodrigues Ferreira Lins

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.