Association between pregnant women with SARS-CoV-2 and the risk of preterm labor
DOI:
https://doi.org/10.33448/rsd-v11i9.31887Keywords:
Obstetric labor, premature; Coronavirus; Neonatology.Abstract
Objective: To investigate the existence of scientific evidence in the literature linking pregnant women with SARS-CoV-2 to preterm labor. Method: This is an integrtaive review carried out in the following databases: BVS, SciELO, MEDLINE/PubMed e Cochrane. Eighteen studies were included. Results: The most common comorbidities were hypertension and diabetes. There were mentions of intrauterine growth restriction and low birth weight newborns. The most common type of delivery was cesarean and the occurrence of premature births was described in all studies. In 77,7% of the studies, neonates tested positive for COVID-19. Conclusion: Worsening maternal status may indicate a risk factor for premature birth. Neonatal infection by SARS-CoV-2 has been reported, but there are gaps in the mechanism of vertical transmission and the impacts for preterm infants. The prematurity rate in pregntant women infected with COVID-19 is higher than in healthy pregnant women.
References
Allotey, J., Stallings. E., Bonet, M., Yap, M., Chatterjee, S., & Kew, T. (2020). Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ, 370:m3320. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459193/. 10.1136/bmj.m3320.
Amaral, L.M., Wallace, K., Owens, M., & LaMarca. B. (2017). Pathophysiology and Current Clinical Management of Preeclampsia. Curr Hypertens Rep, 19(8), 61. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916784/pdf/nihms960604.pdf. 10.1007/s11906-017-0757-7.
Amaral, W.N.D., Moraes, C.L., Rodrigues, A.P.D.S., Noll, M., Arruda, J.T., & Mendonça, C.R. (2020). Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review. Healthcare (Basel), 8(4), 511. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712854/. 10.3390/healthcare8040511.
Antoun, L., Taweel, N.E., Ahmed, I., Patni, S., & Honest, H. (2020). Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. Eur J Obstet Gynecol Reprod Biol, 252, 559-62. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362841. 10.1016/j.ejogrb.2020.07.008.
Akhtar, H., Patel, C., Abuelgasim, E., & Harky, A. (2020). COVID-19 (SARS-CoV-2) Infection in Pregnancy: A Systematic Review. Gynecol Obstet Invest, 85(4), 295–306. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490507/. 10.1159/000509290.
Ashraf, M.A., Keshavarz, P., Hosseinpour, P., Erfani, A., Roshanshad, A., & Pourdast, A. (2020) Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the Possibility of Vertical Transmission. J Reprod Infertil, 21(3), 157-68. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362089/.
Botelho, L.L.R., Cunha, C.C.A., & Macedo, M. (2011). O Método da Revisão Integrativa nos Estudos Organizacionais. Gestão e Sociedade (Belo Horizonte), 5(11), 121- 136. https://www.gestaoesociedade.org/gestaoesociedade/article/view/1220/906.
Capobianco, G., Saderi, L., Aliberti, S., Mondoni, M., Piana, A., & Dessole, F. (2020). COVID- 19 in pregnant women: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol, 252, 543-58. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363619/. 10.1016/j.ejogrb.2020.07.006.
Chandrasekharan, P., Vento, M., Trevisanuto, D., Partridge, E., Underwood, M.A., & Wiedeman, J. (2020). Neonatal Resuscitation and Postresuscitation Care of Infants Born to Mothers with Suspected or Confirmed SARS-CoV-2 Infection. Am J Perinatol, 37(8), 813-24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356083/. 10.1055/s-0040- 1709688.
Chi, J., Gong, W., & Gao, Q. (2020). Clinical characteristics and outcomes of pregnant women with COVID-19 and the risk of vertical transmission: a systematic review. Arch Gynecol Obstet, 1–9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706177/. 10.1007/s00404-020- 05889-5.
Dashraath, P., Wong, J.L.J., Lim, M.X.K., Lim, L.M., Li, S., & Biswas, A. (2020). Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gyneco, 222(6), 521-31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270569/. 10.1016/j.ajog.2020.03.021.
Di Mascio, D., Khalil, A., Saccone, G., Rizzo, G., Buca, D., & Liberati, M. (2020). Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM, 2(2), 100107. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104131/?report=classic. 10.1016/j.ajogmf.2020.100107.
Diriba, K., Awulachew, E., & Getu, E. (2020). The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal- fetal transmission: a systematic review and meta-analysis. Eur J Med Res, 25(1), 39. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471638/. 10.1186/s40001-020- 00439-w.
Dong, L., Tian, J., He, S., Zhu, C., Wang, J., Liu, C., & Yang, J. (2020). Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAM, 323(18), 1846- 1848. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099527/. 10.1001/jama.2020.4621.
Dubey, P., Reddy, S.Y., Manuel, S., & Dwivedi, A.K. (2020). Maternal and neonatal characteristics and outcomes among COVID-19 infected women: An updated systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol, 252, 490-501. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373687/. 10.1016/j.ejogrb.2020.07.034.
Egloffa, C., Vauloup-Fellousb, C., Piconea, O., Mandelbrota, L., & Roquesc, P. (2020). Evidence and possible mechanisms of rare maternal-fetal transmission of SARS-CoV-2. J Clin Virol, 128, 104447. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233246/pdf/main.pdf. https://doi.org/10.1016/j.jcv.2020.104447.
Gao,Y., Ye, L., Zhang, J., Yin, Y., Liu, M., & Yu, H. (2020). Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis. BMC Infect Dis, 20, 564. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396931/. 10.1186/s12879-020- 05274-2.
Goldenberg, R.L., Culhane, J.F., Iams, J.D., & Romero, R. (2008). Epidemiology and causes of preterm birth. Lancet, 371(9606), 75-84. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134569/. 10.1016/S0140- 6736(08)60074-4.
Juan. J., Gil, M.M., Rong, Z., Zhang, Y., Yang, H., & Poon, L.C. (2020). Effect of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcome: systematic review. Ultrasound Obstet Gynecol, 56(1), 15-27. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276742/. 10.1002/uog.22088.
Karimi-Zarchi, M., Neamatzadeh, H., Dastgheib, S.A., Abbasi, H., Mirjalili, S.R., Behforouz, A., Ferdosian, F., & Bahrami, R. (2020). Vertical Transmission of Coronavirus Disease 19 (COVID- 19) from Infected Pregnant Mothers to Neonates: A Review. Fetal Pediatr Pathol, 39(3), 246-50. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157948/. 10.1080/15513815.2020.1747120.
Kong, L., Nilsson, I.A.K., Gissler, M., & Lavebratt, C. (2019). Associations of Maternal Diabetes and Body Mass Index With Offspring Birth Weight and Prematurity. JAMA Pediat, 173(4), 371-78. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450270/. 10.1001/jamapediatrics.2018.5541.
Li, N., Han, L., Peng, M., Lv, Y., Ouyang, Y., & Liu, K. (2020). Maternal and Neonatal Outcomes of Pregnant Women With Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case- Control Study. Clin Infec Dis, 71(16), 2035-41. https://academic.oup.com/cid/article/71/16/2035/5813589#. https://doi.org/10.1093/cid/ciaa352.
Liu, H., Wang, L.L., Zhao, S.J., Kwak Kim, J., Mor, G., & Liao, A.H. (2020). Why are pregnant women susceptible to viral infection: an immunological viewpoint?. J. Reprod. Immunol, 139, 103122. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156163/. https://doi.org/10.1016/j.jri.2020.103122.
Melo, G.C., & Araújo, K.C.G.M. (2020). COVID-19 infection in pregnant women, preterm delivery, birth weight, and vertical transmission: a systematic review and meta-analysis. Cad. Saúde Pública, 36(7), e00087320. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2020000702001&lng=en. https://doi.org/10.1590/0102-311x00087320.
Mendes, K.D.S., Silveira, R.C.C.P., & Galvão, C.M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto Contexto Enferm, 17(4), 758-64. https://www.redalyc.org/pdf/714/71411240017.pdf.
Miller, S.L., Huppi, P.S., & Mallard, C. (2026). The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome. J Physiol, 594(4), 807-23. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753264/. 10.1113/JP271402.
Mullins, E., Evans, D., Viner, R.M., O'Brien, P., & Morris. E. (2020). Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol, 55(5), 586-92. https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.22014. https://doi.org/10.1002/uog.22014.
Narang, K., Enninga, E.A.L., Gunaratne, M.D.S.K., Ibirogba, E.R., Trad, A.T.A., & Elrefaei, A. (2020). SARS-CoV-2 Infection and COVID-19 During Pregnancy: A Multidisciplinary Review. Mayo Clin Proc, 95(8), 1750-65. https://pubmed.ncbi.nlm.nih.gov/32753148/. 10.1016/j.mayocp.2020.05.011.
Novoa, R.H., Quintana, W., Llancarí, P., Urbina-Quispe, K., Guevara-Ríos, E., & Ventura, W. (2020). Maternal clinical characteristics and perinatal outcomes among pregnant women with coronavirus disease 2019. A systematic review. Travel Med Infect Dis, 39, 101919. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674121/. 10.1016/j.tmaid.2020.101919.
Parazzini, F., Bortolus, R., Mauri, P.A., Favilli, A., Gerli, S., & Ferrazzi, E. (2020). Delivery in pregnant women infected with SARS‐CoV‐2: A fast review. Int J Gynaecol Obstet. 150(1), 41-46. https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.13166. https://doi.org/10.1002/ijgo.13166.
Pettirosso, E., Giles, M., Cole, S., & Rees, M. (2020). COVID-19 and pregnancy: A review of clinical characteristics, obstetric outcomes and vertical transmission. Aust N Z J Obstet Gynecol, 60(5), 640-659. https://pubmed.ncbi.nlm.nih.gov/32779193/. 10.1111/ajo.13204.
Poon, L.C., Yang, H., Lee, J.C.S., Copel, J.A., Leung, T.Y., & Zhang, Y. (2020). ISUOG Interim Guidance on 2019 novel coronavirus infection during pregnancy and puerperium: information for healthcare professionals. Ultrasound Obstet Gynecol, 55(5), 700-708. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228229/. 10.1002/uog.22013.
Raschetti, R., Vivanti, A.J., Vauloup-Fellous, C., Loi, B., Benachi, A., & De Luca, D. (2020). Synthesis and systematic review of reported neonatal SARS-CoV-2 infections. Nat Commun, 11, 5164. https://www.nature.com/articles/s41467-020-18982-9. https://doi.org/10.1038/s41467-020-18982-9.
Rodrigues, C., Baía, I., Domingues, R., & Barros, H. (2020). Pregnancy and Breastfeeding During COVID-19 Pandemic: A Systematic Review of Published Pregnancy Cases. Front Public Health, 8, 558144. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719788/. 10.3389/fpubh.2020.558144.
Safadi, M.A.P. (2020). The intriguing features of COVID-19 in children and its impact on the pandemic. J Pediatr (Rio J), 96(3), 265-8. https://www.scielo.br/pdf/jped/v96n3/pt_0021-7557-jped-96-03-0265.pdf. https://doi.org/10.1016/j.jped.2020.04.001.
Salvatore, C.M., Han, J.Y., Acker, K.P., Tiwari, P., Jin, J., & Brandler, M. (2020). Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study. Lancet Child Adolesc Health, 4, 721–27. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377726/pdf/main.pdf. https://doi.org/10.1016/ S2352-4642(20)30235-2.
Secretaria de Saúde do Estado do Ceará. (2014). Protocolos de Obstetrícia. Fortaleza: Secretaria da Saúde do Estado do Ceará. https://www.saude.ce.gov.br/wp-content/uploads/sites/9/2018/06/protocolos_obstetricia_sesa_ce_2014_.pdf.
Seixas Filho, J.T., Seyfarth, M.S.C., Cunha, D.M., Silveira, G.R.R.A., Guedes, E.F., & Orsini, M. (2020). Recomendações de Prevenção da Saúde Materno-Infantil na Pandemia da COVID- 19 por meio de Protocolos Médicos. Rev Augustus, 25(51), 316-34. https://revistas.unisuam.edu.br/index.php/revistaaugustus/article/view/555/305.
Smith, V., Seo, D., Warty, R., Payne, O., Salih, M., & Chin, K.L. (2020). Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review. PLoS One, 15(6), e0234187. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272020/. 10.1371/journal.pone.0234187.
Soares, A.C.C., Silva, K., & Zuanetti, P.A. (2017). Variáveis de risco para o desenvolvimento da linguagem associadas à prematuridade. Audiol Commun Res, 22, e1745. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2317- 64312017000100332&lng=en. https://doi.org/10.1590/2317-6431-2016-1745.
Sociedade Brasileira de Pediatria. (2019). Nota técnica - Novembro: Mês da Prevenção da Prematuridade. Sociedade Brasileira de Pediatria (SBP). https://www.sbp.com.br/fileadmin/user_upload/Nota_Tecnica_2019_Prematuridade.p df.
Souza, M.T., Silva, M.D., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8(1), 102-6. https://www.scielo.br/scielo.php?pid=S1679- 45082010000100102&script=sci_arttext&tlng=pt. http://dx.doi.org/10.1590/s1679-45082010rw1134.
Toso, B.R.G.O., Gaíva, M.A., Nascimento, F.G., & Mandetta, M.A. (2020) Caracterização da COVID- 19 em crianças hospitalizadas. Rev Soc Bras Enferm Ped, 20(Especial COVID- 19), 36-48. https://journal.sobep.org.br/wp-content/uploads/articles_xml/2238-202X-sobep-20-spe-0036/2238-202X-sobep-20- spe-0036.x65337.pdf. 10.31508/1676-3793202000000125.
Wenling, Y., Junchao, Q., Xiao, Z., & Ouyang, S. (2020). Pregnancy and COVID-19: management and challenges. Rev Inst Med Trop Sao Paulo, 62, e62. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458076/. 10.1590/s1678- 9946202062062.
World Health Organization. (2018). Preterm birth. WHO. https://www.who.int/en/news-room/fact-sheets/detail/preterm-birth.
Yang, R., Mei, H., Zheng, T., Fu, Q., Zhang, Y., & Buka, S. (2020). Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China. BMC Med, 18, 330. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568966/. 10.1186/s12916- 020-01798-1.
Yan, J., Guo. J., Fan, C., Juan, J., Yu, X., & Li, J. (2020). Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol, 223(1), 111.e1- 111.e14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177142/. 10.1016/j.ajog.2020.04.014.
Yee, J., Kim, W., Han, J.M., Yoon, H.Y., Lee, N., & Lee, K.E. (2020). Clinical manifestations and perinatal outcomes of pregnant women with COVID-19: a systematic review and meta- analysis. Sci Rep, 10(1),18126. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581768/. 10.1038/s41598-020- 75096-4.
Zaigham, M., & Andersson, O. (2020). Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand, 99(7), 823-29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262097/. 10.1111/aogs.13867.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Ana Aurora Reis Campos Neves Ferrão; Fabíola Mara Gonçalves de Siqueira Amaral; Lara Mabelle Milfont Boeckmann; Rita de Cássia Melão de Morais
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
