Associação entre gestantes com SARS-CoV-2 e o risco de trabalho de parto prematuro

Autores

DOI:

https://doi.org/10.33448/rsd-v11i9.31887

Palavras-chave:

Trabalho de parto prematuro; Coronavírus; Neonatologia.

Resumo

Objetivo: Investigar na literatura a existência de evidências científicas que associem gestantes com SARS-CoV-2 ao trabalho de parto prematuro. Método: Trata-se de uma revisão integrativa realizada nas bases de dados: BVS, SciELO, MEDLINE/PubMed e Cochrane. Foram incluídos 18 artigos. Resultados: As comorbidades maternas mais comuns foram a hipertensão arterial e a diabetes. Houveram menções de restrição de crescimento intrauterino e de nascimento de recém-nascidos de baixo peso. O tipo de parto mais comum foi a cesariana e a ocorrência de nascimentos prematuros foi descrita em todos os estudos. Em 77,7% dos estudos, neonatos testaram positivo para COVID-19. Conclusão: A piora do estado materno pode indicar um fator de risco para parto prematuro. A infecção neonatal pelo SARS-CoV-2 foi relatada, porém existem lacunas sobre o mecanismo da transmissão vertical e os impactos para os neonatos prematuros. O índice de prematuridade em gestantes infectadas pela COVID-19 é maior que em gestantes saudáveis.

Biografia do Autor

Ana Aurora Reis Campos Neves Ferrão, Rede D’Or São Luiz

Enfermeira graduada em Enfermagem pela Universidade de Brasília e especialista em Neonatologia pelo Hospital das Clínicas (HC-FMUSP). Trainee Rede D’Or São Luiz

Fabíola Mara Gonçalves de Siqueira Amaral, Universidade de Brasília

Professora Assistente da Universidade de Brasília

Lara Mabelle Milfont Boeckmann, Universidade de Brasília

Professora Adjunta da Universidade de Brasília - UnB

Referências

Allotey, J., Stallings. E., Bonet, M., Yap, M., Chatterjee, S., & Kew, T. (2020). Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ, 370:m3320. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459193/. 10.1136/bmj.m3320.

Amaral, L.M., Wallace, K., Owens, M., & LaMarca. B. (2017). Pathophysiology and Current Clinical Management of Preeclampsia. Curr Hypertens Rep, 19(8), 61. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916784/pdf/nihms960604.pdf. 10.1007/s11906-017-0757-7.

Amaral, W.N.D., Moraes, C.L., Rodrigues, A.P.D.S., Noll, M., Arruda, J.T., & Mendonça, C.R. (2020). Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review. Healthcare (Basel), 8(4), 511. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712854/. 10.3390/healthcare8040511.

Antoun, L., Taweel, N.E., Ahmed, I., Patni, S., & Honest, H. (2020). Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. Eur J Obstet Gynecol Reprod Biol, 252, 559-62. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362841. 10.1016/j.ejogrb.2020.07.008.

Akhtar, H., Patel, C., Abuelgasim, E., & Harky, A. (2020). COVID-19 (SARS-CoV-2) Infection in Pregnancy: A Systematic Review. Gynecol Obstet Invest, 85(4), 295–306. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490507/. 10.1159/000509290.

Ashraf, M.A., Keshavarz, P., Hosseinpour, P., Erfani, A., Roshanshad, A., & Pourdast, A. (2020) Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the Possibility of Vertical Transmission. J Reprod Infertil, 21(3), 157-68. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362089/.

Botelho, L.L.R., Cunha, C.C.A., & Macedo, M. (2011). O Método da Revisão Integrativa nos Estudos Organizacionais. Gestão e Sociedade (Belo Horizonte), 5(11), 121- 136. https://www.gestaoesociedade.org/gestaoesociedade/article/view/1220/906.

Capobianco, G., Saderi, L., Aliberti, S., Mondoni, M., Piana, A., & Dessole, F. (2020). COVID- 19 in pregnant women: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol, 252, 543-58. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363619/. 10.1016/j.ejogrb.2020.07.006.

Chandrasekharan, P., Vento, M., Trevisanuto, D., Partridge, E., Underwood, M.A., & Wiedeman, J. (2020). Neonatal Resuscitation and Postresuscitation Care of Infants Born to Mothers with Suspected or Confirmed SARS-CoV-2 Infection. Am J Perinatol, 37(8), 813-24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356083/. 10.1055/s-0040- 1709688.

Chi, J., Gong, W., & Gao, Q. (2020). Clinical characteristics and outcomes of pregnant women with COVID-19 and the risk of vertical transmission: a systematic review. Arch Gynecol Obstet, 1–9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706177/. 10.1007/s00404-020- 05889-5.

Dashraath, P., Wong, J.L.J., Lim, M.X.K., Lim, L.M., Li, S., & Biswas, A. (2020). Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gyneco, 222(6), 521-31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270569/. 10.1016/j.ajog.2020.03.021.

Di Mascio, D., Khalil, A., Saccone, G., Rizzo, G., Buca, D., & Liberati, M. (2020). Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM, 2(2), 100107. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104131/?report=classic. 10.1016/j.ajogmf.2020.100107.

Diriba, K., Awulachew, E., & Getu, E. (2020). The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal- fetal transmission: a systematic review and meta-analysis. Eur J Med Res, 25(1), 39. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471638/. 10.1186/s40001-020- 00439-w.

Dong, L., Tian, J., He, S., Zhu, C., Wang, J., Liu, C., & Yang, J. (2020). Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAM, 323(18), 1846- 1848. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099527/. 10.1001/jama.2020.4621.

Dubey, P., Reddy, S.Y., Manuel, S., & Dwivedi, A.K. (2020). Maternal and neonatal characteristics and outcomes among COVID-19 infected women: An updated systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol, 252, 490-501. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373687/. 10.1016/j.ejogrb.2020.07.034.

Egloffa, C., Vauloup-Fellousb, C., Piconea, O., Mandelbrota, L., & Roquesc, P. (2020). Evidence and possible mechanisms of rare maternal-fetal transmission of SARS-CoV-2. J Clin Virol, 128, 104447. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233246/pdf/main.pdf. https://doi.org/10.1016/j.jcv.2020.104447.

Gao,Y., Ye, L., Zhang, J., Yin, Y., Liu, M., & Yu, H. (2020). Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis. BMC Infect Dis, 20, 564. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396931/. 10.1186/s12879-020- 05274-2.

Goldenberg, R.L., Culhane, J.F., Iams, J.D., & Romero, R. (2008). Epidemiology and causes of preterm birth. Lancet, 371(9606), 75-84. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134569/. 10.1016/S0140- 6736(08)60074-4.

Juan. J., Gil, M.M., Rong, Z., Zhang, Y., Yang, H., & Poon, L.C. (2020). Effect of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcome: systematic review. Ultrasound Obstet Gynecol, 56(1), 15-27. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276742/. 10.1002/uog.22088.

Karimi-Zarchi, M., Neamatzadeh, H., Dastgheib, S.A., Abbasi, H., Mirjalili, S.R., Behforouz, A., Ferdosian, F., & Bahrami, R. (2020). Vertical Transmission of Coronavirus Disease 19 (COVID- 19) from Infected Pregnant Mothers to Neonates: A Review. Fetal Pediatr Pathol, 39(3), 246-50. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157948/. 10.1080/15513815.2020.1747120.

Kong, L., Nilsson, I.A.K., Gissler, M., & Lavebratt, C. (2019). Associations of Maternal Diabetes and Body Mass Index With Offspring Birth Weight and Prematurity. JAMA Pediat, 173(4), 371-78. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450270/. 10.1001/jamapediatrics.2018.5541.

Li, N., Han, L., Peng, M., Lv, Y., Ouyang, Y., & Liu, K. (2020). Maternal and Neonatal Outcomes of Pregnant Women With Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case- Control Study. Clin Infec Dis, 71(16), 2035-41. https://academic.oup.com/cid/article/71/16/2035/5813589#. https://doi.org/10.1093/cid/ciaa352.

Liu, H., Wang, L.L., Zhao, S.J., Kwak Kim, J., Mor, G., & Liao, A.H. (2020). Why are pregnant women susceptible to viral infection: an immunological viewpoint?. J. Reprod. Immunol, 139, 103122. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156163/. https://doi.org/10.1016/j.jri.2020.103122.

Melo, G.C., & Araújo, K.C.G.M. (2020). COVID-19 infection in pregnant women, preterm delivery, birth weight, and vertical transmission: a systematic review and meta-analysis. Cad. Saúde Pública, 36(7), e00087320. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2020000702001&lng=en. https://doi.org/10.1590/0102-311x00087320.

Mendes, K.D.S., Silveira, R.C.C.P., & Galvão, C.M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto Contexto Enferm, 17(4), 758-64. https://www.redalyc.org/pdf/714/71411240017.pdf.

Miller, S.L., Huppi, P.S., & Mallard, C. (2026). The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome. J Physiol, 594(4), 807-23. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753264/. 10.1113/JP271402.

Mullins, E., Evans, D., Viner, R.M., O'Brien, P., & Morris. E. (2020). Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol, 55(5), 586-92. https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.22014. https://doi.org/10.1002/uog.22014.

Narang, K., Enninga, E.A.L., Gunaratne, M.D.S.K., Ibirogba, E.R., Trad, A.T.A., & Elrefaei, A. (2020). SARS-CoV-2 Infection and COVID-19 During Pregnancy: A Multidisciplinary Review. Mayo Clin Proc, 95(8), 1750-65. https://pubmed.ncbi.nlm.nih.gov/32753148/. 10.1016/j.mayocp.2020.05.011.

Novoa, R.H., Quintana, W., Llancarí, P., Urbina-Quispe, K., Guevara-Ríos, E., & Ventura, W. (2020). Maternal clinical characteristics and perinatal outcomes among pregnant women with coronavirus disease 2019. A systematic review. Travel Med Infect Dis, 39, 101919. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674121/. 10.1016/j.tmaid.2020.101919.

Parazzini, F., Bortolus, R., Mauri, P.A., Favilli, A., Gerli, S., & Ferrazzi, E. (2020). Delivery in pregnant women infected with SARS‐CoV‐2: A fast review. Int J Gynaecol Obstet. 150(1), 41-46. https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.13166. https://doi.org/10.1002/ijgo.13166.

Pettirosso, E., Giles, M., Cole, S., & Rees, M. (2020). COVID-19 and pregnancy: A review of clinical characteristics, obstetric outcomes and vertical transmission. Aust N Z J Obstet Gynecol, 60(5), 640-659. https://pubmed.ncbi.nlm.nih.gov/32779193/. 10.1111/ajo.13204.

Poon, L.C., Yang, H., Lee, J.C.S., Copel, J.A., Leung, T.Y., & Zhang, Y. (2020). ISUOG Interim Guidance on 2019 novel coronavirus infection during pregnancy and puerperium: information for healthcare professionals. Ultrasound Obstet Gynecol, 55(5), 700-708. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228229/. 10.1002/uog.22013.

Raschetti, R., Vivanti, A.J., Vauloup-Fellous, C., Loi, B., Benachi, A., & De Luca, D. (2020). Synthesis and systematic review of reported neonatal SARS-CoV-2 infections. Nat Commun, 11, 5164. https://www.nature.com/articles/s41467-020-18982-9. https://doi.org/10.1038/s41467-020-18982-9.

Rodrigues, C., Baía, I., Domingues, R., & Barros, H. (2020). Pregnancy and Breastfeeding During COVID-19 Pandemic: A Systematic Review of Published Pregnancy Cases. Front Public Health, 8, 558144. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719788/. 10.3389/fpubh.2020.558144.

Safadi, M.A.P. (2020). The intriguing features of COVID-19 in children and its impact on the pandemic. J Pediatr (Rio J), 96(3), 265-8. https://www.scielo.br/pdf/jped/v96n3/pt_0021-7557-jped-96-03-0265.pdf. https://doi.org/10.1016/j.jped.2020.04.001.

Salvatore, C.M., Han, J.Y., Acker, K.P., Tiwari, P., Jin, J., & Brandler, M. (2020). Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study. Lancet Child Adolesc Health, 4, 721–27. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377726/pdf/main.pdf. https://doi.org/10.1016/ S2352-4642(20)30235-2.

Secretaria de Saúde do Estado do Ceará. (2014). Protocolos de Obstetrícia. Fortaleza: Secretaria da Saúde do Estado do Ceará. https://www.saude.ce.gov.br/wp-content/uploads/sites/9/2018/06/protocolos_obstetricia_sesa_ce_2014_.pdf.

Seixas Filho, J.T., Seyfarth, M.S.C., Cunha, D.M., Silveira, G.R.R.A., Guedes, E.F., & Orsini, M. (2020). Recomendações de Prevenção da Saúde Materno-Infantil na Pandemia da COVID- 19 por meio de Protocolos Médicos. Rev Augustus, 25(51), 316-34. https://revistas.unisuam.edu.br/index.php/revistaaugustus/article/view/555/305.

Smith, V., Seo, D., Warty, R., Payne, O., Salih, M., & Chin, K.L. (2020). Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review. PLoS One, 15(6), e0234187. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272020/. 10.1371/journal.pone.0234187.

Soares, A.C.C., Silva, K., & Zuanetti, P.A. (2017). Variáveis de risco para o desenvolvimento da linguagem associadas à prematuridade. Audiol Commun Res, 22, e1745. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2317- 64312017000100332&lng=en. https://doi.org/10.1590/2317-6431-2016-1745.

Sociedade Brasileira de Pediatria. (2019). Nota técnica - Novembro: Mês da Prevenção da Prematuridade. Sociedade Brasileira de Pediatria (SBP). https://www.sbp.com.br/fileadmin/user_upload/Nota_Tecnica_2019_Prematuridade.p df.

Souza, M.T., Silva, M.D., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8(1), 102-6. https://www.scielo.br/scielo.php?pid=S1679- 45082010000100102&script=sci_arttext&tlng=pt. http://dx.doi.org/10.1590/s1679-45082010rw1134.

Toso, B.R.G.O., Gaíva, M.A., Nascimento, F.G., & Mandetta, M.A. (2020) Caracterização da COVID- 19 em crianças hospitalizadas. Rev Soc Bras Enferm Ped, 20(Especial COVID- 19), 36-48. https://journal.sobep.org.br/wp-content/uploads/articles_xml/2238-202X-sobep-20-spe-0036/2238-202X-sobep-20- spe-0036.x65337.pdf. 10.31508/1676-3793202000000125.

Wenling, Y., Junchao, Q., Xiao, Z., & Ouyang, S. (2020). Pregnancy and COVID-19: management and challenges. Rev Inst Med Trop Sao Paulo, 62, e62. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458076/. 10.1590/s1678- 9946202062062.

World Health Organization. (2018). Preterm birth. WHO. https://www.who.int/en/news-room/fact-sheets/detail/preterm-birth.

Yang, R., Mei, H., Zheng, T., Fu, Q., Zhang, Y., & Buka, S. (2020). Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China. BMC Med, 18, 330. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568966/. 10.1186/s12916- 020-01798-1.

Yan, J., Guo. J., Fan, C., Juan, J., Yu, X., & Li, J. (2020). Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol, 223(1), 111.e1- 111.e14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177142/. 10.1016/j.ajog.2020.04.014.

Yee, J., Kim, W., Han, J.M., Yoon, H.Y., Lee, N., & Lee, K.E. (2020). Clinical manifestations and perinatal outcomes of pregnant women with COVID-19: a systematic review and meta- analysis. Sci Rep, 10(1),18126. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581768/. 10.1038/s41598-020- 75096-4.

Zaigham, M., & Andersson, O. (2020). Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand, 99(7), 823-29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262097/. 10.1111/aogs.13867.

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11/07/2022

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FERRÃO, A. A. R. C. N.; AMARAL, F. M. G. de S. .; BOECKMANN, L. M. M. .; MORAIS, R. de C. M. de. Associação entre gestantes com SARS-CoV-2 e o risco de trabalho de parto prematuro. Research, Society and Development, [S. l.], v. 11, n. 9, p. e34411931887, 2022. DOI: 10.33448/rsd-v11i9.31887. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/31887. Acesso em: 22 dez. 2024.

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