Cambios leucocitarios en pacientes con COVID-19 observado en la extensión de sangre periférica
DOI:
https://doi.org/10.33448/rsd-v10i11.19838Palabras clave:
Coronavirus; Leucocitos; Hematología; Infección por SARS-CoV-2; Recuento de leucocitos.Resumen
El objetivo del estudio fue verificar las principales alteraciones en el linaje leucocitario provocadas por la infección por SARS-CoV-2, virus de origen zoonótico responsable de la enfermedad conocida como COVID-19. El SARS-CoV-2 afecta a varios sistemas, incluido el sistema hematopoyético, que provoca cambios en los linajes de los leucocitos. Los pacientes infectados por el virus SARS-CoV-2 presentaron alteraciones numéricas y morfológicas en el linaje leucocitario, siendo más significativas la linfopenia y la neutrofilia. En cuanto a la morfología, se observaron varias anomalías. Con frecuencia se observaron linfocitos plasmocitoides y linfocitos reactivos similares a células de Downey. También estaban presentes monocitos displásicos y neutrófilos hipolobulados, clasificados como anomalía adquirida de Pseudo Pelger-Huet. Estas anomalías se correlacionaron con una mayor probabilidad de ingreso en la UCI y progresión a la muerte. Hubo una correspondencia entre el recuento normal de eosinófilos y la progresión positiva de la enfermedad, lo que sugiere que la regeneración de eosinófilos está relacionada con la recuperación de la enfermedad. Este conjunto de cambios no se ha observado en ninguna otra neumonía viral. El recuento diferencial de leucocitos es una prueba rápida y fácil de realizar, que puede ayudar al equipo médico a clasificar a los pacientes con afecciones graves o no graves, y brindar orientación sobre la evolución de la enfermedad.
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Derechos de autor 2021 Carolina Coradi; Suellen Laís Vicentino Vieira
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
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