A hydroalcoholic blackberry leaf extract improved glucose tolerance and body composition and attenuated depression-like symptoms in ovariectomized rats.

Mateus Ferreira  Mendes; Maria Thereza Ottoni  Figueiró; Mayara Regina  Nunes; Regina Eloina dos Santos  Pereira; Isabella Rocha  Dias; Lauane Gomes  Moreno; Kinulpe Honorato  Sampaio; Elizabethe Adriana  Esteves

doi:10.33448/rsd-v12i2.39334

Autores

Mateus Ferreira Mendes Universidade Federal dos Vales do Jequitinhonha e Mucuri https://orcid.org/0000-0002-7818-1783
Maria Thereza Ottoni Figueiró Universidade Federal dos Vales do Jequitinhonha e Mucuri https://orcid.org/0000-0001-8354-4078
Mayara Regina Nunes Universidade Federal dos Vales do Jequitinhonha e Mucuri https://orcid.org/0000-0002-4495-1487
Regina Eloina dos Santos Pereira Universidade Federal dos Vales do Jequitinhonha e Mucuri https://orcid.org/0000-0002-2126-8968
Isabella Rocha Dias Universidade Federal dos Vales do Jequitinhonha e Mucuri https://orcid.org/0000-0002-6372-4589
Lauane Gomes Moreno Universidade Federal dos Vales do Jequitinhonha e Mucuri https://orcid.org/0000-0003-4006-4466
Kinulpe Honorato Sampaio Universidade Federal dos Vales do Jequitinhonha e Mucuri https://orcid.org/0000-0002-8154-9606
Elizabethe Adriana Esteves Universidade Federal dos Vales do Jequitinhonha e Mucuri https://orcid.org/0000-0003-1435-8364

DOI:

https://doi.org/10.33448/rsd-v12i2.39334

Palavras-chave:

Composição corporal; Menopausa; Morus nigra; Tolerância à glicose; Depressão; Ansiedade.

Resumo

As folhas da amoreira preta (Morus nigra) são utilizadas na menopausa para alívio de alguns sintomas e vem sendo investigadas em distúrbios metabólicos. Entretanto, poucos estudos investigaram seus efeitos em disfunções metabólicas e comportamentais associadas à menopausa. Nosso objetivo foi avaliar os efeitos do extrato hidroalcóolico de folhas da M. nigra (EA) na composição corporal, tolerância à glicose e nos comportamentos semelhantes à depressão e ansiedade em ratas ovariectomizadas. Para tal, 36 ratas Wistar foram distribuídas nos grupos: C – controle; COvx – ovariectomizado; EAOvx – ovariectomizado e suplementado com EA (400 mg.kg^-1 massa corporal/dia). Avaliou-se a composição corporal por DEXA, a tolerância à glicose pelo teste de tolerância oral à glicose e os comportamentos semelhantes a depressão e ansiedade pelos testes nado forçado e labirinto em cruz elevada, respectivamente. A ingestão alimentar e o ganho de massa corporal foram maiores para EAOvx, seguido por COvx e por último por C (p<0,05). O grupo EAOvx ganhou menos gordura corporal do que o COvx (p<0,05) e foi mais tolerante à glicose em comparação ao C e COvx (p<0,05). No labirinto em cruz elevada, COvx e EAOvx permaneceram por menos tempo nos braços abertos e mais tempo nos braços fechados que os C (p<0,05). No nado forçado, a imobilidade foi maior para COvx, seguido pelo C e EAOvx (p<0,05). O EA protegeu as ratas ovariectomizadas do ganho de gordura corporal, restabeleceu a tolerância à glicose e atenuou o comportamento semelhante à depressão. Fitoestrogênios e outros compostos bioativos do EA podem estar envolvidos nesses efeitos.

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O extrato hidroalcóolico das folhas de amora preta melhorou a tolerância à glicose, a composição corporal e atenuou sintomas de depressão em ratas ovariectomizadas.

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